A 2 Year Survival Analysis of Oral Squamous Cell Carcinoma- A Prospective Study on 25 Patients in a Tertiary Care Hospital

Abstract

Oral Squamous cell carcinomas (OSCC) are the most common type of variant causing oral cancers, contributing for around 90%. The overall survival of these patients is below 50%.  The postoperative overall survival (OS) has not improved over years much despite of advanced surgical techniques and invention of various anticancer drugs. The prevalence of oral cancer is high among the Southeast Asian countries due to the wide use of tobacco products, especially in the chewable form. In India, oral cancer is one of the commonest cancers in both sexes, accounting for 30% of the overall cancer burden, which is likely to increase in the future. We explored the factors associated with recurrence of OSCC and analyzed the survival rate of 25 patients for 2 years

AIM:The aim of this study to calculate the 2 year survival rate of patients with oral squamous cell carcinoma.

METHODS & MATERIALS:A prospective cohort study of 25 patients with biopsy proven OSCC who presented to Tertiary care hospital in Indore, Madhya Pradesh was performed from August 2017 to July 2019. Patients were operated and had received adjuvant treatment based on the histopathological reports and then follow up of 2 years was done to analyse the 2 year survival rate.
RESULTS:Twenty five patients were analysed out of which 85% were consuming tobacco, mainly in chewable form.13patients  had buccal mucosa cancer, 5 had tongue cancers, 1 patient had upper alveolus cancer, 5 patients had lower alveolus cancers, and 1 patient with floor of mouth cancer. The tumors was staged as Stage I in 8patients , stage II in 3patients , stage III in 2 patients  and stage IV in 12 patients.  Postoperative radiotherapy was given to 24 patients. 3 patients had local recurrence  and 2 patients had distant metastasis. The overall survival of the patients in our study were 80 % for 2 years.  
CONCLUSION:Positive lymph node is very important factor affecting recurrence of the disease and survival of the patient. The overall survival is better in patients without the involvement of lymph node and in patients with early stage of oral cancer as compared to the patients with lymph nodal involvement and in advanced stages of oral cancer.