The Influence of Renal Function on In-Hospital Complications in Patients with St-Elevation Myocardial Infarction

Abstract

Objective: The goal of this study was to examine in-hospital complications in patients with acute ST-elevationmyocardialinfarction(STEMI)withadifferentrenalfunction.

Methods: 351 patients were included in the study. The percutaneous coronary intervention wasperformedonallpatients.116hadaGFR<60ml/min/1.73m2(Group1),120≥60ml/min/1.73m2and <90ml/min/1.73m2(Group2)and115≥90ml/min/1.73m2(Group3).Otherparametersinthegroupswere comparable. Acute heart failure(AHF), in-hospital pneumonia(IP), pulseless ventriculartachycardia(VT) or ventricular fibrillation(VF), new-onset atrial fibrillation(AF) or atrial flutter(AFl), andin-hospitaldeath(ID)were allcompared betweenstudy groups.

Results: Mean GFR in Group 1 was 48.2 ±10.4 , in Group 2 74.7±8.7 and , in Group 3 104.1±14.6 (p <0.001).TheincidenceofAForAFlwashigherinGroup1thaninGroups2and3:12.1%,5.8%,and3.5%,respectively(p<0.05).Group3hadsignificantlylowerratesofAHFthanGroups1and2:10.3%,5.8%,and 0.9 %, respectively (p < 0.05). There was also a significant difference between groups whencomparing the rate of IP: Group 1 had reasonably higher rates of IP than Group 2 and Group 3: 13.8%,6.7%, and 4.3% (p < 0.05), respectively. The authors discovered no significant differences in additionalcomplications: pulseless VT or VF occurred in 2.6% , 3.3%, and 0.9%, respectively (p > 0.05). ID was 3.4%inGroup1, 0.8%inGroup2, and0inGroup3,(p>0.05).

Conclusion:PatientswithlowerGFRweremorelikelytodevelopin-hospitalAHF,IP,andAForAFlinSTEMI.