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The aim of the study is to try to find natural alternatives used in the treatment of cancerous diseases. The relationship between the secondary metabolism product of propolis metabolism and the most dangerous disease that affects humans, which is cancer, was studied using the colon cancer cell line (SW480) in humans. The study included testing the possibility of the toxic effect of Iraqi propolis against the human colon cancer cell line using four sequential concentrations of the nano-extract:)1%,3%.5%.7%)mg/ml For a period of exposure (24) hours at the level of significance (p<0.05). The chemical detection of the compounds present in the crude propolis was done by HPLC teast, as it was found that the raw propolis contains (phenol, flavone, glycoside, alkaloid, tannin, saponins). The cytotoxic and genotoxic effects of the extract were investigated, as the results showed that Iraqi Nanopropolisparticals has very severe cytotoxicity and genotoxicity, which increases with increasing concentration through an increase in growth inhibition rates and a decrease in the number of cancer cells.