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Currently, intensive study of the clinical and epidemiological features of COVID-19 is continuing. In this regard, the development of new means of its prevention and treatment is becoming increasingly relevant. The most vulnerable category of people, along with older people, is pregnant women. Due to their low immune reactivity, they are more susceptible to severe complications than others. In this article, we conducted a retrospective analysis of 280 case histories of pregnant women living in Republics of the North Caucasus Federal District of the Russian Federation (the Republic of Ingushetia, the Republic of Dagestan and the Republic of North Ossetia-Alania) who received medical care in 2021 with an officially confirmed diagnosis of mild and moderate COVID-19 coronavirus infection. Analyzing the pregnancy outcomes in patients with COVID-19, we found that 15.3% of women were delivered through the natural birth canal, 10.7% of women in labor due to an increase in respiratory failure and, as a consequence, fetal hypoxia, were delivered by caesarean section. 2.5% of cases ended in spontaneous abortion in the first trimester. 71.4% of pregnant women who underwent COVID-19 were hospital discharged with progressive pregnancy at different gestation periods.As a result of the work carried out, we analyzed a number of clinical and laboratory data in pregnant women with COVID-19 in dynamics assessed the course of the disease in different periods of pregnancy by region and assessed the effectiveness of pharmacotherapy.