Investigation of SARS-COV-2 Antibodies in Healthcare Workers Developed Due to COVID-19 Vaccines

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Burcu Gürer Giray, Gökçe Güven Açık, Sevda Meryem Baş, Yunus Emre Bulut, Mustafa Sırrı Kotanoğlu


Background: Extra obligations and measures are required for health care workers (HCWs) due to COVID-19.

Objectives:This study aims to investigate anti-S1 IgG response after inactive SARS-CoV-2 vaccine and the factors affecting it for HCWs.

Methods:36 previously infected and 164 naive HCWs were included. Roche Elecsys SARS-CoV-2 kit was used for humoral immune response quantitative determination in serum samples taken after first and second doses.

Results: Average antibody levels of 164 negative HCWs were 15.82 ± 8.59 IU/mL and 26.042 ± 10.73 IU/mL while 36 positive HCWs were 66.083 ± 33.927 IU/mL and 90 ± 27.012 IU/mL respectively. A statistically significant difference was observed between the antibody levels after the doses (p<0.0001). In this study, average level after first dose in positive HCWs was statistically higher than the second dose in negative HCWs (p<0.0001).

Conclusions: We suggest that prospective clinical studies on antibody levels and protection duration are required to prevent COVID-19.

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