Are Diabetic Patients with Metabolic Syndrome and Tuberculosis are Most Vulnerable to COVID-19 Infection?

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Rajavardhana T., Geethavani M., Vanitha Rani N., Ponnusankar S., Sreedhar V., Rajanandh M. G.

Abstract

Background and aims

Numerous patients with coronavirus infection 2019 (COVID-19) have comorbidities identified with the metabolic syndrome (MS) during their illness course. Patients with compromised immune levels are under considerable risk of COVID-19 infection.


Methods

We systematically searched the PubMed and Google Scholar databases until July 22nd, 2020, and got to the accessible information on the relationship between metabolic syndrome, diabetes, Tuberculosis (TB), and COVID-19.


Results


Most of the investigations assumed that 5-30% of TB patients have diabetes mellitus (DM). Diabetes is a significant cause of Lower respiratory tract infections (LRTI), including TB. MS is rising in developed and developing countries in both males and females. It leads to a reduction in pulmonary function and more chances of death. Difficulty in breathing at rest conditions and exacerbations are the most common symptoms in Metabolic syndrome, TB, and COVID-19 infection.


Conclusion

Diabetes, MS, and TB are the significant risk factors influencing the development and prognosis of  COVID-19. Recommendations for clinical practice, which include the performance of tridirectionally screening [TB, DM, COVID-19]. Monitoring of blood glucose levels in patients suffering from Tuberculosis and COVID-19 infection. In case of the presence of diabetes in patients suffering from those infections, management of the glycemic condition has to be done to stabilize the patient's condition.

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