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The study was aimed to evaluate the antimicrobial activity of marine seaweed Sargassum wightii Greville ex J. Agardh. The antimicrobial activities of the extracts were determined by agar-well diffusion technique. The three different solvent extracts such as methanol, chloroform and ethyl acetate were tested against five Gram-positive bacteria like Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans, Bacillus subtilis and Micrococcus luteus, five Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphii, Klebsiella pneumoniae and Proteus vulgaris and two fungal pathogens like Aspergillus niger and Candida albicans. All the three solvent extracts showed the significant antibacterial activity against Gram-negative bacteria than Gram-positive bacteria. The chloroform extracts showed significant antibacterial activity followed by ethyl acetate and methanol. In case of antifungal activity, methanol extracts exhibited highest activity against Candida albicans followed by ethyl acetate and chloroform extracts.