The Role of Anti-Dsdna Antibody in Progression of Chronic Renal Failure in Iraqi Patients Inthi-Qar Province

Abstract

Chronic renal failure defined as any functional or structural defect of the kidneys for more than 3 months. The kidneys contribute effectively to maintaining the immune hemostasis in the body. This study was conducted to find out the role of anti- double stranded DNA antibody in kidney disorders, which eventually lead to chronic renal failureby using ELISA kit. The study included 90 Iraqi individuals, 45 patients with Chronic Renal Failure and 45 healthy control.  The results showed that female to male ratio in patients was 1.6:1, the majorityof the patients was  the age group 60-69 years (31.1%).Serum anti-double stranded DNA antibody was significantly increased among chronic renal failure patients(14.853± 4.394 IU/ml)  as compared to healthy controls(7.849± 2.782 IU/ ml)P < 0.01.It was concluded that elevated levels of anti-DNA in serum of patients could be considered as a prognostic factor for chronic renal failure in Iraqi patients in Thi-Qar province