Serum Vaspin Level in Elderly T2DM Patients and Macrovascular Complications

Abstract

Background: In older persons with diabetes, macrovascular complications are a major cause of death, a major source of disability, and a big contributor to their lower quality of life. The aim of the present study was to determination of serum vaspin levels in elderly patients with type 2 DM.

Patients and methods: A case control, cross sectional study, included 69 subject (above 65 years old) and carried out in the outpatient clinic and Geriatrics unit of internal medicine department, and laboratory part was done in medical biochemistry department, faculty of Medicine, Zagazig University Hospitals. They were divided into 3 groups; Group I included (23) elderly healthy subjects as control group; Group II included (23) elderly diabetic patients without complications and Group III included (23) elderly diabetic patients with macrovascular complications.

Results: There was a statistical significance increase in BMI and waist circumference among Group III compared Group II.  There was a statistical significance decrease in HC among Group II & III. Finally there was a statistical significance increase in WHR among Group III. There was a statistical significance increase in SBP among Group III compare to Group I & II. There was a statistical significance increase in platelets count among Group III. There was a statistical significance increase in HbA1c and FBS, fasting insulin, HOMA IR and C peptide among all cases groups compared to Group I (control) and among Group III compared to Group II. There was a statistical significance increase in 2 h post prandial blood sugar among cases groups compared to Group I. There was a statistical significance increase in Cholesterol, TG, LDL and VLDL among Group III. Finally Group III had a statistical significance decrease in HDL compared to Group I & II.

Conclusion: Serum vaspin levels are disparate among diabetics, being high in uncomplicated and low in complicated diabetics, both compared to non-diabetics. Low serum vaspin level may be a putative biomarker of diabetic complications.