Oxidative Stress Marker Malondialdehyde in Ischemic Heart Disease and Chronic Periodontitis Patients

Abstract

Background: Ischemic heart diseases and chronic periodontitis appear to be linked to elevated oxidative stress. The main and best-studied outcome of polyunsaturated fatty acid peroxidation, malondialdehyde (MDA), has been found to rise in response-to oxidative-stress. Ꞁhis study aims to assess oxidative-stress marker malondialdehyde in coronary artery disease and chronic-periodontitis patients and to evaluate the rolesof saliva in diagnosis for this biochemical investigation.

Subjects and Methods: In this study, 80 participants were included; 40 of them had ischemic heart disease (IHD), with ages ranging from 42 to 80; the remaining 40 were age- and sex-matched healthy volunteers. Intra oral examination were done for all subjects and the clinical periodontal sum score (CPSS) was calculated. For all the serum and salivary sample, an estimate of malondialdehyde has been made.

Results: When coṃpared to healthy-controls, IHD patients' ṃean serum MDA levels were considerably higher (Ƥ 0.001). In comparison to healthy controls, IHD patients had a higher mean level of salivary MDA. Every rise in CPSS tertiles increases serum MDA by 0.23 mol/L, and salivary MDA increases by 0.027 for every increase in age in years. Being an IHD. case was.projected to increase serum-MDA by a mean-of 1.003 mol/L compared to healthy-controls.

Conclusions: Higher MDA levels in serum and saliva have-been linked to increased oxidative-stress in.patients with ischemic heart-disease. With the course of chronic periodontitis, serum MDA rises.