Jundishapur Journal of Microbiology

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Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals

Mehrnoush Maheronnaghsh ORCID 1 , Mahnaz Fatahinia ORCID 1 , 2 , * , Parvin Dehghan ORCID 3 , Ali Zarei Mahmoudabadi ORCID 1 , 2 and Mahnaz Kheirkhah ORCID 3
Authors Information
1 Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Article information
  • Jundishapur Journal of Microbiology: May 31, 2019, 12 (5); e91556
  • Published Online: May 28, 2019
  • Article Type: Research Article
  • Received: March 13, 2019
  • Revised: May 14, 2019
  • Accepted: May 17, 2019
  • DOI: 10.5812/jjm.91556

To Cite: Maheronnaghsh M, Fatahinia M, Dehghan P, Zarei Mahmoudabadi A, Kheirkhah M. Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals, Jundishapur J Microbiol. 2019 ; 12(5):e91556. doi: 10.5812/jjm.91556.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000;13(4):547-58. doi: 10.1128/cmr.13.4.547-558.2000. [PubMed: 11023956]. [PubMed Central: PMC88948].
  • 2. Aarstehfar A, Daneshnia F, Kord M, Roudbary M, Zarrinfar H, Fang W, et al. Comparison of 21-Plex PCR and API 20C AUX, MALDI-TOF MS, and rDNA sequencing for a wide range of clinically isolated yeast species: Improved identification by combining 21-Plex PCR and API 20C AUX as an alternative strategy for developing countries. Front Cell Infect Microbiol. 2019;9:21. doi: 10.3389/fcimb.2019.00021. [PubMed: 30828570]. [PubMed Central: PMC6385604].
  • 3. Jacobsen ID, Wilson D, Wachtler B, Brunke S, Naglik JR, Hube B. Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther. 2012;10(1):85-93. doi: 10.1586/eri.11.152. [PubMed: 22149617].
  • 4. Esmailzadeh A, Zarrinfar H, Fata A, Sen T. High prevalence of candiduria due to non-albicans Candida species among diabetic patients: A matter of concern? J Clin Lab Anal. 2018;32(4). e22343. doi: 10.1002/jcla.22343. [PubMed: 29076587].
  • 5. Lo HJ, Kohler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C. albicans mutants are avirulent. Cell. 1997;90(5):939-49. doi: 10.1016/S0092-8674(00)80358-X. [PubMed: 9298905].
  • 6. Ramage G, VandeWalle K, Lopez-Ribot JL, Wickes BL. The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol Lett. 2002;214(1):95-100. doi: 10.1111/j.1574-6968.2002.tb11330.x. [PubMed: 12204378].
  • 7. Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence. 2013;4(2):119-28. doi: 10.4161/viru.22913. [PubMed: 23302789]. [PubMed Central: PMC3654610].
  • 8. Schaller M, Borelli C, Korting HC, Hube B. Hydrolytic enzymes as virulence factors of Candida albicans. Mycoses. 2005;48(6):365-77. doi: 10.1111/j.1439-0507.2005.01165.x. [PubMed: 16262871].
  • 9. K D, T J, A M. In vitro evaluation of virulence factors of Candida species isolated from oral cavity. J Microbiol Antimicrob. 2015;7(3):28-32. doi: 10.5897/jma2015.0337.
  • 10. Kabir MA, Hussain MA, Ahmad Z. Candida albicans: A model organism for studying fungal pathogens. ISRN Microbiol. 2012;2012:538694. doi: 10.5402/2012/538694. [PubMed: 23762753]. [PubMed Central: PMC3671685].
  • 11. Bhat V, Sharma S, Shetty V, Shastry C, Rao V. Extracellular enzymes of Candida albicans and their role in development of denture stomatitis-a review. JIADS. 2011;2(1):26-30.
  • 12. Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011;3. doi: 10.3402/jom.v3i0.5771. [PubMed: 21547018]. [PubMed Central: PMC3087208].
  • 13. Almeida RS, Brunke S, Albrecht A, Thewes S, Laue M, Edwards JE, et al. the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog. 2008;4(11). e1000217. doi: 10.1371/journal.ppat.1000217. [PubMed: 19023418]. [PubMed Central: PMC2581891].
  • 14. Dominic RM, Shenoy S, Baliga S. Candida biofilms in medical devices: evolving trends. Kathmandu Univ Med J (KUMJ). 2007;5(3):431-6. [PubMed: 18604070].
  • 15. Maheronnaghsh M, Tolouei S, Dehghan P, Chadeganipour M, Yazdi M. Identification of Candida species in patients with oral lesion undergoing chemotherapy along with minimum inhibitory concentration to fluconazole. Adv Biomed Res. 2016;5:132. doi: 10.4103/2277-9175.187394. [PubMed: 27656601]. [PubMed Central: PMC5025917].
  • 16. Singh A, Singh PK, Kumar A, Chander J, Khanna G, Roy P, et al. Molecular and matrix-assisted laser desorption ionization-time of flight mass spectrometry-based characterization of clinically significant melanized fungi in India. J Clin Microbiol. 2017;55(4):1090-103. doi: 10.1128/JCM.02413-16. [PubMed: 28100598]. [PubMed Central: PMC5377836].
  • 17. Samaranayake LP, Raeside JM, MacFarlane TW. Factors affecting the phospholipase activity of Candida species in vitro. Sabouraudia. 1984;22(3):201-7. doi: 10.1080/00362178485380331. [PubMed: 6379916].
  • 18. Aoki T, Moro H, Koshio N, Tamura T, Tanabe Y, Kawai H, et al. [Results of antifungal susceptibility testing of Candida species and trends of antifungal use in Niigata university medical and dental hospital]. Rinsho Byori. 2010;58(7):658-63. Japanese. [PubMed: 20715508].
  • 19. D'Eca Junior A, Silva AF, Rosa FC, Monteiro SG, de Maria Silva Figueiredo P, de Andrade Monteiro C. In vitro differential activity of phospholipases and acid proteinases of clinical isolates of Candida. Rev Soc Bras Med Trop. 2011;44(3):334-8. doi: 10.1590/S0037-86822011005000036. [PubMed: 21901875].
  • 20. Lan D, Hou S, Yang N, Whiteley C, Yang B, Wang Y. Optimal production and biochemical properties of a lipase from Candida albicans. Int J Mol Sci. 2011;12(10):7216-37. doi: 10.3390/ijms12107216. [PubMed: 22072943]. [PubMed Central: PMC3211034].
  • 21. Tsang CS, Chu FC, Leung WK, Jin LJ, Samaranayake LP, Siu SC. Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus. J Med Microbiol. 2007;56(Pt 10):1393-8. doi: 10.1099/jmm.0.47303-0. [PubMed: 17893179].
  • 22. Luo G, Samaranayake LP, Yau JY. Candida species exhibit differential in vitro hemolytic activities. J Clin Microbiol. 2001;39(8):2971-4. doi: 10.1128/JCM.39.8.2971-2974.2001. [PubMed: 11474025]. [PubMed Central: PMC88272].
  • 23. Manns JM, Mosser DM, Buckley HR. Production of a hemolytic factor by Candida albicans. Infect Immun. 1994;62(11):5154-6. [PubMed: 7927798]. [PubMed Central: PMC303238].
  • 24. Price MF, Wilkinson ID, Gentry LO. Plate method for detection of phospholipase activity in Candida albicans. Sabouraudia. 1982;20(1):7-14. doi: 10.1080/00362178285380031. [PubMed: 7038928].
  • 25. Kuriyama T, Williams DW, Lewis MA. In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiol Immunol. 2003;18(6):405-7. doi: 10.1046/j.0902-0055.2002.00100.x. [PubMed: 14622349].
  • 26. Willis AM, Coulter WA, Fulton CR, Hayes JR, Bell PM, Lamey PJ. Oral candidal carriage and infection in insulin-treated diabetic patients. Diabet Med. 1999;16(8):675-9. doi: 10.1046/j.1464-5491.1999.00134.x. [PubMed: 10477213].
  • 27. Galan-Ladero MA, Blanco MT, Sacristan B, Fernandez-Calderon MC, Perez-Giraldo C, Gomez-Garcia AC. Enzymatic activities of Candida tropicalis isolated from hospitalized patients. Med Mycol. 2010;48(1):207-10. doi: 10.3109/13693780902801242. [PubMed: 19274599].
  • 28. Fatahinia M, Poormohamadi F, Zarei Mahmoudabadi A. Comparative study of esterase and hemolytic activities in clinically important Candida species, isolated from oral cavity of diabetic and non-diabetic individuals. Jundishapur J Microbiol. 2015;8(3). e20893. doi: 10.5812/jjm.20893. [PubMed: 25861439]. [PubMed Central: PMC4386073].
  • 29. Venkatesan G, Uppoor A, Naik D, Kadkampally D, Maddi A. Oral Candida carriage and morphotype differentiation in chronic periodontitis patients with and without diabetes in the indian sub-continent. Dent J (Basel). 2015;3(4):123-31. doi: 10.3390/dj3040123. [PubMed: 29567932]. [PubMed Central: PMC5851191].
  • 30. Mushi MF, Mtemisika CI, Bader O, Bii C, Mirambo MM, Gross U, et al. High oral carriage of non-albicans Candida spp. among HIV-infected individuals. Int J Infect Dis. 2016;49:185-8. doi: 10.1016/j.ijid.2016.07.001. [PubMed: 27401585].
  • 31. Mirmortazavi A, Rajati Haghi H, Fata A, Zarrinfar H, Bagheri H, Mehranfard A. Kinetics of antifungal activity of home-generated ozonated water on Candida albicans. Curr Med Mycol. 2018;4(2):27-31. doi: 10.18502/cmm.4.2.67. [PubMed: 30324154]. [PubMed Central: PMC6181063].
  • 32. Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD. Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species. Front Microbiol. 2016;7:2173. doi: 10.3389/fmicb.2016.02173. [PubMed: 28127295]. [PubMed Central: PMC5226953].
  • 33. Sitheeque MA, Samaranayake LP. Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia). Crit Rev Oral Biol Med. 2003;14(4):253-67. doi: 10.1177/154411130301400403. [PubMed: 12907694].
  • 34. Cannon RD, Chaffin WL. Oral colonization by Candida albicans. Crit Rev Oral Biol Med. 1999;10(3):359-83. doi: 10.1177/10454411990100030701. [PubMed: 10759414].
  • 35. Wu T, Samaranayake LP, Cao BY, Wang J. In-vitro proteinase production by oral Candida albicans isolates from individuals with and without HIV infection and its attenuation by antimycotic agents. J Med Microbiol. 1996;44(4):311-6. doi: 10.1099/00222615-44-4-311. [PubMed: 8606360].
  • 36. Watanabe T, Takano M, Murakami M, Tanaka H, Matsuhisa A, Nakao N, et al. Characterization of a haemolytic factor from Candida albicans. Microbiology. 1999;145 ( Pt 3):689-94. doi: 10.1099/13500872-145-3-689. [PubMed: 10217503].
  • 37. Kumar CP, Menon T, Sundararajan T, Nalini S, Thirunarayan MA, Rajasekaran S, et al. Esterase activity of Candida species isolated from immunocompromised hosts. Rev Iberoam Micol. 2006;23(2):101-3. doi: 10.1016/S1130-1406(06)70023-7. [PubMed: 16854187].
  • 38. Noori M, Dakhili M, Sepahvand A, Davari N. Evaluation of esterase and hemolysin activities of different Candida species isolated from vulvovaginitis cases in Lorestan Province, Iran. Curr Med Mycol. 2017;3(4):1-5. doi: 10.29252/cmm.3.4.1. [PubMed: 29707672]. [PubMed Central: PMC5917094].
  • 39. Ahmad S, Khan Z, Mokaddas E, Khan ZU. Isolation and molecular identification of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Kuwait. J Med Microbiol. 2004;53(Pt 7):633-7. doi: 10.1099/jmm.0.05315-0. [PubMed: 15184534].
  • 40. Shehabi AA, Nazzal SA, Dajani N. Putative virulence factors of Candida species colonizing respiratory tracts of patients. Microb Ecol Health Dis. 2009;16(4):214-7. doi: 10.1080/08910600410025419.
  • 41. Issa SY, Badran EF, Aqel KF, Shehabi AA. Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants. BMC Pediatr. 2011;11:79. doi: 10.1186/1471-2431-11-79. [PubMed: 21902841]. [PubMed Central: PMC3182898].
  • 42. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: A persistent public health problem. Clin Microbiol Rev. 2007;20(1):133-63. doi: 10.1128/CMR.00029-06. [PubMed: 17223626]. [PubMed Central: PMC1797637].

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