Jundishapur Journal of Microbiology

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Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Neda Kiasat 1 , 2 , Ali Rezaei-Matehkolaei 1 , 2 , Ali Zarei Mahmoudabadi 1 , 2 , * , Khadijeh Hamidavi Mohamadpour 3 , Shahla Molavi 4 and Nastaran Khoshayand 3
Authors Information
1 Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Midwifery Department, Reproductive Health Promotion Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Microbiology: 12 (3); e89815
  • Published Online: March 4, 2019
  • Article Type: Research Article
  • Received: January 23, 2019
  • Revised: February 18, 2019
  • Accepted: February 21, 2019
  • DOI: 10.5812/jjm.89815

To Cite: Kiasat N, Rezaei-Matehkolaei A, Zarei Mahmoudabadi A, Hamidavi Mohamadpour K , Molavi S , et al. Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study, Jundishapur J Microbiol. Online ahead of Print ; 12(3):e89815. doi: 10.5812/jjm.89815.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Jombo GTA, Opajobi SO, Egah DZ, Banwat EB, Akaa PD. Symptomatic vulvovaginal candidiasis and genital colonization by Candida species in Nigeria. J Publ Health Epidemiol. 2010;2(6):147-51.
  • 2. Marrazzo J. Extracts from "concise clinical evidence": Vulvovaginal candidiasis. BMJ. 2002;325(7364):586. doi: 10.1136/bmj.325.7364.586.
  • 3. Gamarra S, Morano S, Dudiuk C, Mancilla E, Nardin ME, de Los Angeles Mendez E, et al. Epidemiology and antifungal susceptibilities of yeasts causing vulvovaginitis in a teaching hospital. Mycopathologia. 2014;178(3-4):251-8. doi: 10.1007/s11046-014-9780-2. [PubMed: 25005365].
  • 4. Mendling W, Brasch J, Cornely OA, Effendy I, Friese K, Ginter-Hanselmayer G, et al. Guideline: Vulvovaginal candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). Mycoses. 2015;58 Suppl 1:1-15. doi: 10.1111/myc.12292. [PubMed: 25711406].
  • 5. Sobel JD. Vulvovaginal candidosis. Lancet. 2007;369(9577):1961-71. doi: 10.1016/S0140-6736(07)60917-9. [PubMed: 17560449].
  • 6. Ahmad A, Khan AU. Prevalence of Candida species and potential risk factors for vulvovaginal candidiasis in Aligarh, India. Eur J Obstet Gynecol Reprod Biol. 2009;144(1):68-71. doi: 10.1016/j.ejogrb.2008.12.020. [PubMed: 19261369].
  • 7. Al-Aali KY. Prevalence of vaginal candidiasis among pregnant women attending Al-Hada military hospital, western region, Taif, Saudi Arabia. Int J Sci Res. 2015;4(5):1736-43.
  • 8. Arfiputri DS, Hidayati AN, Handayani S, Ervianti E. Risk factors of vulvovaginal candidiasis in dermato-venereology outpatients clinic of Soetomo general hospital, Surabaya, Indonesia. Afr J Infect Dis. 2018;12(1 Suppl):90-4. doi: 10.2101/Ajid.12v1S.13. [PubMed: 29619437]. [PubMed Central: PMC5876779].
  • 9. Goncalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol. 2016;42(6):905-27. doi: 10.3109/1040841X.2015.1091805. [PubMed: 26690853].
  • 10. Eckert LO. Clinical practice. Acute vulvovaginitis. N Engl J Med. 2006;355(12):1244-52. doi: 10.1056/NEJMcp053720. [PubMed: 16990387].
  • 11. Belayneh M, Sehn E, Korownyk C. Recurrent vulvovaginal candidiasis. Can Fam Physician. 2017;63(6):455. [PubMed: 28615397]. [PubMed Central: PMC5471085].
  • 12. Bahram A, Hamid B, Zohre T. Prevalence of bacterial vaginosis and impact of genital hygiene practices in non-pregnant women in Zanjan, Iran. Oman Med J. 2009;24(4):288-93. doi: 10.5001/omj.2009.58. [PubMed: 22216382]. [PubMed Central: PMC3243866].
  • 13. Habibipour R. Prevalence rate of vulvovaginal candidiasis and identification of Candida species in women in referred to Hamedan hospitals 2013-2014, west of Iran. Zahedan J Res Med Sci. 2016;18(3). e6250. doi: 10.17795/zjrms-6250.
  • 14. Hedayati MT, Taheri Z, Galinimoghadam T, Aghili SR, Yazdani Cherati J, Mosayebi E. Isolation of different species of Candida in patients with vulvovaginal candidiasis from Sari, Iran. Jundishapur J Microbiol. 2015;8(4). e15992. doi: 10.5812/jjm.8(4)2015.15992. [PubMed: 26034533]. [PubMed Central: PMC4449843].
  • 15. Zarei Mahmoudabadi A, Najafyan M, Alidadi M. Clinical study of Candida vaginitis in Ahvaz, Iran and susceptibility of agents to topical antifungal. Pak J Med Sci. 2010;26(3):607-10.
  • 16. Jamilian M, Mashadi E, Sarmadi F, Banijamali M, Farhadi E, Ghanatpishe E. [Frequancy of vulvovaginal candidiasis species in nonpregnant 15-50 years old women in spring 2005 in Arak]. J Arak Univ Med Sci. 2007;10(2):7-14. Persian.
  • 17. Gharaghani M, Ahmadi B, Taheripour Sisakht M, Ilami O, Aramesh S, Mouhamadi F, et al. Identification of Candida species isolated from vulvovaginal candidiasis patients by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Yasuj southwestern Iran. Jundishapur J Microbiol. 2018;11(8). doi: 10.5812/jjm.65359.
  • 18. Roudbary M, Roudbarmohammadi S, Bakhshi B, Farhadi Z, Nikoomanesh F. Identification of Candida species isolated from Iranian women with vaginal candidiasis by PCR-RFLP method. Eur J Exp Biol. 2013;3(6):365-9.
  • 19. Anderson MR, Klink K, Cohrssen A. Evaluation of vaginal complaints. JAMA. 2004;291(11):1368-79. doi: 10.1001/jama.291.11.1368. [PubMed: 15026404].
  • 20. Kazemi A, Falahati M, Hajipoor A, Jafari A, Asgharzadeh M. Comparison of phenotypic tests and PCR to detect Candida albicans From vaginal specimens (Tabriz, 2009-2010). Jundishapur J Microbiol. 2013;6(2):122-6. doi: 10.5812/jjm.4734.
  • 21. Rezaei-Matehkolaei A, Shafiei S, Zarei-Mahmoudabadi A. Isolation, molecular identification, and antifungal susceptibility profiles of vaginal isolates of Candida species. Iran J Microbiol. 2016;8(6):410-7. [PubMed: 28491253]. [PubMed Central: PMC5420397].
  • 22. Fathima K, Rajendran R. A study of isolation and identification of non-albicans Candida species from clinically suspected cases of vulvovaginitis. Int J Curr Microbiol App Sci. 2014;3(12):147-59.
  • 23. Deorukhkar SC, Saini S, Mathew S. Non-albicans Candida infection: An emerging threat. Interdiscip Perspect Infect Dis. 2014;2014:615958. doi: 10.1155/2014/615958. [PubMed: 25404942]. [PubMed Central: PMC4227454].
  • 24. Goulart LS, Santiago EF, Ramon JL, Moura SV, Silva AR, Silva Jr IF, et al. Species distribution and antifungal susceptibility to vulvovaginal Candida spp. in southern Mato Grosso State, Brazil. Brazilian J Pathol Lab Med. 2016;52(4):233-7. doi: 10.5935/1676-2444.20160039.
  • 25. Bonyadpour B, Akbarzdeh M, Pakshir K, Mohagheghzadeh AA. [In vitro susceptibility of fluconazole, clotrimazole and toucrium polium smoke product on Candida isolates of vaginal candidiasis]. Armaghane Danesh. 2009;14(2):87-96. Persian.
  • 26. ElFeky DS, Gohar NM, El-Seidi EA, Ezzat MM, AboElew SH. Species identification and antifungal susceptibility pattern of Candida isolates in cases of vulvovaginal candidiasis. Alexandria J Med. 2016;52(3):269-77. doi: 10.1016/j.ajme.2015.10.001.
  • 27. Larkin EL, Dharmaiah S, Ghannoum MA. Biofilms and beyond: Expanding echinocandin utility. J Antimicrob Chemother. 2018;73(suppl_1):i73-81. doi: 10.1093/jac/dkx451. [PubMed: 29304214].
  • 28. Workowski KA, Bolan GA; Centers for Disease Control Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1-137. [PubMed: 26042815]. [PubMed Central: PMC5885289].
  • 29. Mohammadi R, Mirhendi H, Rezaei-Matehkolaei A, Ghahri M, Shidfar MR, Jalalizand N, et al. Molecular identification and distribution profile of Candida species isolated from Iranian patients. Med Mycol. 2013;51(6):657-63. doi: 10.3109/13693786.2013.770603. [PubMed: 23470036].
  • 30. White TJ, Bruns T, Lee S, Taylor J. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. PCR Protocols: A guide to methods and applications. 1990;18(1):315-22. doi: 10.1016/b978-0-12-372180-8.50042-1.
  • 31. Mohamadi J, Havasian MR, Panahi J, Pakzad I. Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014. Bioinformation. 2015;11(4):203-6. doi: 10.6026/97320630011203. [PubMed: 26124561]. [PubMed Central: PMC4479047].
  • 32. Esmaeilzadeh S, Mahdavi Omran S, Rahmani Z. Frequency and etiology of vulvovaginal candidiasis in women referred to a gynecological center in Babol, Iran. Int J Fertil Steril. 2009;3(2):74-7.
  • 33. Abdullahi Nasir I, Uchenna E, Onyia J, Ifunanya AL. Prevalence of vulvovaginal candidiasis among nonpregnant women attending a tertiary health care facility in Abuja, Nigeria. Res Rep Trop Med. 2015;6:37-42. doi: 10.2147/rrtm.s82984.
  • 34. Ozcan SK, Budak F, Yucesoy G, Susever S, Willke A. Prevalence, susceptibility profile and proteinase production of yeasts causing vulvovaginitis in Turkish women. APMIS. 2006;114(2):139-45. doi: 10.1111/j.1600-0463.2006.apm_360.x. [PubMed: 16519751].
  • 35. Ugwa EA. Vulvovaginal candidiasis in Aminu Kano teaching hospital, North-West Nigeria: Hospital-based epidemiological study. Ann Med Health Sci Res. 2015;5(4):274-8. doi: 10.4103/2141-9248.160185. [PubMed: 26229716]. [PubMed Central: PMC4512120].
  • 36. Lopes PHS, Pacini VL, Norberg AN. Genital infection by Gardnerella vaginalis and Candida spp. among women in Nova Iguacu City, Rio de Janeiro province, Brazil. OALib J. 2017;4(3):1-7. doi: 10.4236/oalib.1103366.
  • 37. Adesiji YO, Ndukwe N, Okanlawon BM. Isolation and antifungal sensitivity to Candida isolates in young females. Cent Eur J Open Med. 2011;6(2):172-6. doi: 10.2478/s11536-010-0071-0.
  • 38. Nwosu CO, Djieyep NA. Candidiasis and trichomoniasis among pregnant women in a rural community in the semi-arid zone, north-eastern Nigeria. West Afr J Med. 2007;26(1):17-9. [PubMed: 17595985].
  • 39. Nnadi DC, Singh S. The prevalence of genital Candida species among pregnant women attending antenatal clinic in a tertiary health center in North-West Nigeria. Sahel Med J. 2017;20(1):33. doi: 10.4103/1118-8561.204333.
  • 40. Saleem B, Jeelani SF, Sher SJ. Frequency of vaginal candidiasis in symptomatic pregnant women attending routine antenatal clinic. Pakistan J Med Sci. 2016;10(3):770-2.
  • 41. Aslam M, Hafeez R, Ijaz S, Tahir M. Vulvovaginal candidiasis in pregnancy. Biomedica. 2008;24:54-6.
  • 42. Kanagal DV, Vineeth V, Kundapur R, Shetty H, Rajesh A. Prevalence of vaginal candidiasis in pregnancy among coastal south Indian women. J Wom Health Issues Care. 2014;3(6). doi: 10.4172/2325-9795.1000168.
  • 43. Holzer I, Farr A, Kiss H, Hagmann M, Petricevic L. The colonization with Candida species is more harmful in the second trimester of pregnancy. Arch Gynecol Obstet. 2017;295(4):891-5. doi: 10.1007/s00404-017-4331-y. [PubMed: 28255766]. [PubMed Central: PMC5350239].
  • 44. Cheraghi M, Rahimi Z, Parsa S. Prevalence of cervical-vaginal infections in the pap-smear samples in Iran. Glob J Health Sci. 2013;6(1):201-6. doi: 10.5539/gjhs.v6n1p201. [PubMed: 24373280]. [PubMed Central: PMC4825389].
  • 45. Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Adelson ME, Mordechai E, et al. Survey of vaginal-flora Candida species isolates from women of different age groups by use of species-specific PCR detection. J Clin Microbiol. 2008;46(4):1501-3. doi: 10.1128/JCM.02485-07. [PubMed: 18305136]. [PubMed Central: PMC2292962].
  • 46. Grigoriou O, Baka S, Makrakis E, Hassiakos D, Kapparos G, Kouskouni E. Prevalence of clinical vaginal candidiasis in a university hospital and possible risk factors. Eur J Obstet Gynecol Reprod Biol. 2006;126(1):121-5. doi: 10.1016/j.ejogrb.2005.09.015. [PubMed: 16256258].

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