Jundishapur Journal of Microbiology

Published by: Kowsar

In Vitro Effects of Ketotifen and Cromolyn Sodium on Promastigotes and Amastigotes of Leishmania major

Lima Asgharpour Sarouey 1 , Khadijeh Khanaliha 2 , Parvaneh Rahimi-Moghaddam 3 , Samaneh Khorrami 4 , Mohammad Saaid Dayer 5 and Fatemeh Tabatabaie 1 , *
Authors Information
1 Department of Parasitology and Mycology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
3 Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
5 Department of Parasitology and Medical Entomology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Article information
  • Jundishapur Journal of Microbiology: January 31, 2019, 12 (1); e82389
  • Published Online: December 24, 2018
  • Article Type: Research Article
  • Received: July 19, 2018
  • Revised: October 24, 2018
  • Accepted: November 5, 2018
  • DOI: 10.5812/jjm.82389

To Cite: Asgharpour Sarouey L , Khanaliha K , Rahimi-Moghaddam P , Khorrami S , Dayer M S , et al. In Vitro Effects of Ketotifen and Cromolyn Sodium on Promastigotes and Amastigotes of Leishmania major, Jundishapur J Microbiol. 2019 ; 12(1):e82389. doi: 10.5812/jjm.82389.

Abstract
Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Savoia D. Recent updates and perspectives on leishmaniasis. J Infect Dev Ctries. 2015;9(6):588-96. doi: 10.3855/jidc.6833. [PubMed: 26142667].
  • 2. Desjeux P. Leishmaniasis: Current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004;27(5):305-18. doi: 10.1016/j.cimid.2004.03.004. [PubMed: 15225981].
  • 3. Khodadadi S, Dakhili M, Akhlaghi L, Haeri M, Tabatabaie F. Three-year epidemiological evaluation of cutaneous leishmaniasis in Qom province (2007-2009). Health Med. 2012;6(9):3056.
  • 4. Kwakye-Nuako G, Mosore MT, Duplessis C, Bates MD, Puplampu N, Mensah-Attipoe I, et al. First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex. Int J Parasitol. 2015;45(11):679-84. doi: 10.1016/j.ijpara.2015.05.001. [PubMed: 26099650].
  • 5. Moore EM, Lockwood DN. Treatment of visceral leishmaniasis. J Glob Infect Dis. 2010;2(2):151-8. doi: 10.4103/0974-777X.62883. [PubMed: 20606971]. [PubMed Central: PMC2889655].
  • 6. Diro E, Lynen L, Ritmeijer K, Boelaert M, Hailu A, van Griensven J. Visceral leishmaniasis and HIV coinfection in East Africa. PloS Negl Trop. 2014;8(6). e2869. doi: 10.1371/journal.pntd.0002869. [PubMed: 24968313]. [PubMed Central: PMC4072530].
  • 7. Rezaei F, Ebrahimzadeh MA, Daryani A, Sharif M, Ahmadpour E, Sarvi S. The inhibitory effect of cromolyn sodium and ketotifen on Toxoplasma gondii entrance into host cells in vitro and in vivo. J parasit Dis. 2016;40(3):1001-5. doi: 10.1007/s12639-014-0623-3. [PubMed: 27605827]. [PubMed Central: PMC4996236].
  • 8. Milner E, Sousa J, Pybus B, Auschwitz J, Caridha D, Gardner S, et al. Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. Eur J Drug Metab Pharmacokinet. 2012;37(1):17-22. doi: 10.1007/s13318-012-0080-2. [PubMed: 22314893].
  • 9. Ibrahim AM, Elhag ER, Mustafa SE. Ketotifen in treatment of uncomplicated falciparum malaria. Saudi Med J. 2000;21(3):257-65. [PubMed: 11533794].
  • 10. Ganguly S, Bandyopadhyay S, Sarkar A, Chatterjee M. Development of a semi-automated colorimetric assay for screening anti-leishmanial agents. J Microbiol Methods. 2006;66(1):79-86. doi: 10.1016/j.mimet.2005.10.011. [PubMed: 16316700].
  • 11. Ghaffarifar F, Esavand Heydari F, Dalimi A, Hassan ZM, Delavari M, Mikaeiloo H. Evaluation of apoptotic and antileishmanial activities of artemisinin on promastigotes and BALB/C Mice Infected with Leishmania major. Iran J Parasitol. 2015;10(2):258-67. [PubMed: 26246824]. [PubMed Central: PMC4522302].
  • 12. Ebrahimisadr P, Ghaffarifar F, Mohammad Hassan Z. In-vitro evaluation of antileishmanial activity and toxicity of artemether with focus on its apoptotic effect. Iran J Pharm Res. 2013;12(4):903-9. [PubMed: 24523770]. [PubMed Central: PMC3920718].
  • 13. Delavari M, Dalimi-Asl A, Ghaffarifar F, Sadraei J. [Effect of aloe-emodin on growth and induction of apoptosis in Leishmania major promastigotes in vitro]. Feyz J Kashan Univ Med Sci. 2013;17(5):422-8. Persian.
  • 14. Zahiri M, Mohebali M, Khanavi M, Sahebgharani M, Saghafipour A, Esmaeili J, et al. Therapeutic effect of scrophularia striata ethanolic extract against localized cutaneous leishmaniasis caused by Leishmania major (MRHO/IR/75/ER). Iran J Public Health. 2016;45(10):1340-7. [PubMed: 27957441]. [PubMed Central: PMC5149498].
  • 15. Hermoso A, Jimenez IA, Mamani ZA, Bazzocchi IL, Pinero JE, Ravelo AG, et al. Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity. Bioorg Med Chem. 2003;11(18):3975-80. [PubMed: 12927858].
  • 16. Doroodgar M, Delavari M, Doroodgar M, Abbasi A, Taherian AA, Doroodgar A. Tamoxifen induces apoptosis of Leishmania major promastigotes in vitro. Korean J Parasitol. 2016;54(1):9-14. doi: 10.3347/kjp.2016.54.1.9. [PubMed: 26951973]. [PubMed Central: PMC4792327].
  • 17. Maroufi Y, Ghaffarifar F, Dalimi AA, Sharifi Z, Hassan Z. [Cantharidin-induced apoptosis in Leishmania major promastigotes and macrophages infected by Leishmania major amastigotes in vitro]. J Mazand Univ Med Sci. 2012;22(89):32-40. Persian.
  • 18. Pinto EG, da Costa-Silva TA, Tempone AG. Histamine H1-receptor antagonists against Leishmania (L.) infantum: An in vitro and in vivo evaluation using phosphatidylserine-liposomes. Acta Trop. 2014;137:206-10. doi: 10.1016/j.actatropica.2014.05.017. [PubMed: 24905294].
  • 19. You L, Ni B, Cao HM. Effects of low dose of ketotifen and chloroquine combination on the infrastructure of chloroquine resistant strain of Plasmodium yoelii. J Shanghai Univ. 2000;4(4):338-42.
  • 20. Daryani A, Ebrahimzadeh MA, Sharif M, Rezaei F, Ahmadpour E, Sarvi S, et al. [The inhibitory effect of ketotifen on entrance of Toxoplasma gondii tachyzoites into macrophages of mouse]. J Mazandaran Univ Med Sci. 2014;23(110):75-80. Persian.
  • 21. Montazeri M, Rezaei K, Ebrahimzadeh MA, Sharif M, Sarvi S, Ahmadpour E, et al. Survey on synergism effect of ketotifen in combination with pyrimethamine in treatment of acute murine toxoplasmosis. Trop Med Health. 2017;45:39. doi: 10.1186/s41182-017-0079-0. [PubMed: 29200930]. [PubMed Central: PMC5697358].
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