IF: 0.957
Cite Score:
1.46
THOMSON REUTERS - SCOPUS

Rapid Detection of Acute Respiratory Virus and Atypical Bacteria Infections in Children

AUTHORS

Cai Xuan 1 , * , Li Yan 1 , Wu Zegang 1

AUTHORS INFORMATION

1 Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China

ARTICLE INFORMATION

Jundishapur Journal of Microbiology: 6 (5); 6236
Published Online: June 30, 2013
Article Type: Research Article
Received: May 6, 2012
Accepted: August 7, 2012
Crossmark

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Acute respiratory infection (ARI) is one of the primary diseases that cause high morbidity and mortality to children especially in developing countries. ARI can come from a number of pathogens, which are not necessarily identical in different regions or groups. As similar symptoms become evident in child ARI without specific particularities, respiratory infectious diseases are most of the time clinically diagnosed and treated less selectively than required, and antibiotics are largely used for non-bacterial respiratory system infections. Therefore, rapid detection of respiratory pathogens is necessary for the correct and appropriate treatment of ARI.

Objectives: To obtain a general understanding of the pathogenic spectrum of ARI for children and provide basis for clinical infection control and pathogenic detection.

Materials and Methods: Serum specimens from 4550 child victims with ARI symptoms were collected and detected for IgM antibodies of nine common pathogens using the indirect immunofluorescence assay (IFA).

Results: Of the 4550 child victims, 3660 were antibody positive (80.4%), with detectable rates of 67.3%, 90.9%, 92.4% and 91.4% for the ? 1, 1< y ? 3, 3 < y ? 6 and > 6 age groups respectively (P < 0.05). Except for Coxiellaburneti (COX), the difference in the detectable rates of other pathogens between the groups was statistically significant. Of the nine pathogens, Mycoplasma pneumoniae (MP) had the highest detectable rate, followed by influenza B virus (FluB), respiratory syncytial virus (RSV), parainfluenza virus (PIV), adenovirus (ADV), influenza A virus (FluA), Legionella pneumophila sero group I (LPN-I), Coxiellaburneti (COX) and Chlamydia pneumoniae (CPn); and 718 suffered mixed infections (81.4%), typically of two pathogens (MP + FLuB).

Conclusions: MP, FluB and RSV are the principal contributors to ARI in the Hubei area, with mixed infections, typically of MP and FluB, being the most common pathogens statistically significant between different age groups.

Keywords

Child Respiratory Tract Infections Pathogen Coinfection

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: