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The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study)

AUTHORS

Mohsen Khorrami 1 , Saeid Tabatabaei 2 , * , Mirabbas Ahmadarabi 3

AUTHORS INFORMATION

1 Razi Hospital, Trauma Research Center Jundishapur University of Medical Sciences, IR Iran

2 Razi Hospital, Trauma Research Center Jundishapur University of Medical Sciences, Saaidt1379@hotmail.com, IR Iran

3 Orthopedic Surgeon, Boroujerd, IR Iran

How to Cite: Khorrami M, Tabatabaei S, Ahmadarabi M. The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study), Jundishapur J Microbiol. Online ahead of Print ; 5(2):427-429. doi: 10.5812/jjm.3521.

ARTICLE INFORMATION

Jundishapur Journal of Microbiology: 5 (2); 427-429
Article Type: Research Article
Received: June 1, 2011
Accepted: November 25, 2011
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Abstract

Background: Antibiotic therapy prevents postoperative infections after orthopedic procedures, but the method and prescribed dose of this therapy are debated. Short-term prophylaxis and long-term prophylaxis are 2 accepted methods after orthopedic procedures.
Objectives: In this prospective observational study, we compared the results of short-term and long-term prophylaxis after elective orthopedic procedures at 2 hospitals of Jundishapur University of Medical Sciences.
Patients and Methods: We divided patients who underwent uneventful orthopedic operations into 2 groups, administered short- and long-term prophylactic antibiotic therapy, respectively, and observed the patients for signs and symptoms of superficial and deep infections. We compared and analyzed the results with SPSS, considering P values of less than 0.001 to indicate a significant difference.
Results: There was no significant difference regarding superficial and deep infections between short- and long-term prophylaxis groups; thus, both methods can be used for prophylaxis after elective orthopedic surgeries, effecting equal rates of success.
Conclusions: Short-term prophylaxis can be used for clean orthopedic procedures with equivalent results as long-term therapy.


  • Implication for health policy/practice/research/medical education:
    In using short-term antibiotic prophylaxis in clean orthopedic procedures we can avoid side effects and also it is more cost-effective.
  • Please cite this paper as:
    Khorrami M; Tabatabaei S, Ahmadarabi M. The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study). Jundishapur J Microbiol.2012;5(2):427-9. DOI: 10.5812/jjm.3521

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Keywords

Antibiotic Short-Term Orthopedic Procedures

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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