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WITHDRAWN:Incidence and Susceptibility Pattern of Metallo-Beta-Lactamase Producers Among Pseudomonas aeruginosa Isolated From Burn Patients at Kurdistan Province


Enayatollah Kalantar 1 , * , Vahideh Torabi 2 , Himen Salimizand 3 , Fariborz Soheili 3 , Rashid Ramezanzadeh 3


1 1)School of Health, Envirbmenatl Health Research Center, Kurdistan University of Medical Sciences, Sanandaj. 2) Department of Pathobiology, School of Medicine, Alborz University of Medical Sciences, kalantar_enayat@yahoo.com, IR Iran

2 Department of Biology, Science and Resaerch Branch, Islamic Azad University, IR Iran

3 Department of Microbiology, School of Medicine, Kurdistan University of Medical Sciences, IR Iran


Jundishapur Journal of Microbiology: 5 (3); 507-510
Article Type: Research Article
Received: April 7, 2011
Accepted: December 1, 2011




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Background: Infection with metallo-beta-lactamase (MBL)-producing organisms, particularly Pseudomonas aeruginosa, is associated with higher mortality and morbidity rates and health care costs.
Objective: In this study, we aimed to determine the etiology of burns and the incidence and susceptibility patterns of metallo-beta-lactamase producers among P. aeruginosa samples that were isolated from burn patients in Kurdistan province.
Patients and Methods: A total of 176 clinical specimens were received for P. aeruginosa testing. Antimicrobial susceptibility testing, determination of MIC, and detection of MBL-producing P. aeruginosa strains were performed per CLSI guidelines.
Results: During the study period, 145 burn patients were admitted to the burn unit of Tohid Hospital. Their mean age and total body surface area (TBSA) were 29 years and 37.7 %, respectively. The mean length of hospital stay was 10 days. Kerosene was the most common cause of burns (60 %), followed by gas (30 %). In the 176 clinical specimens from burn patients, 100 P. aeruginosa isolates were identified. The antibiotic to which most bacteria were resistant was ampicillin (100 %), and the most effective antibiotic was meropenem. Of the 100 P. aeruginosa isolates, 22 (22 %) were positive for MBL production, of which 8 were resistant to imipenem.
Conclusions: Of all burn injuries, 87 (60 %) patients were caused by kerosene, which is used primarily by people in low-income groups to light lamps. Our results demonstrate the serious threat of the spread of metallo-beta-lactamase producers; thus, systematic surveillance for detecting MBL producers is necessary.

Implication for health policy/practice/research/medical education:
An infection among burn patients with MBL resistant P. aeruginosa is associated with significantly higher morbidity, mortality and cost of care.
Please cite this paper as:
Kalantar E, Torabi V, Salimizand H, Soheili F, Ramezanzadeh R. Incidence and Susceptibility Pattern of Metallo-Beta-Lactamase Producers Among Pseudomonas aeruginosa Isolated From Burn Patients at Kurdistan Province. Jundishapur J Microbiol; 5(3):507-10. DOI: 10.5812/jjm.3664

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Kerosene Pseudomonas aeruginosa Burns Therapeutics

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