Jundishapur Journal of Microbiology

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Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

Maryam Zangi # 1 , Azam Bakhshandeh # 1 , Masoumeh Mehrpouya 1 and Majid Shahbazi 1 , 2 , *
Authors Information
1 Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2 Aryatinagene Biopharmaceutical Company, Gorgan, Iran
# These authors are contributed equally as the first author.
Article information
  • Jundishapur Journal of Microbiology: March 31, 2019, 12 (3); e68270
  • Published Online: March 13, 2019
  • Article Type: Research Article
  • Received: March 4, 2018
  • Revised: February 18, 2019
  • Accepted: February 24, 2019
  • DOI: 10.5812/jjm.68270

To Cite: Zangi M , Bakhshandeh A , Mehrpouya M, Shahbazi M. Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran, Jundishapur J Microbiol. 2019 ; 12(3):e68270. doi: 10.5812/jjm.68270.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Kidd-Ljunggren K, Miyakawa Y, Kidd AH. Genetic variability in hepatitis B viruses. J Gen Virol. 2002;83(Pt 6):1267-80. doi: 10.1099/0022-1317-83-6-1267. [PubMed: 12029141].
  • 2. Zhang ZH, Wu CC, Chen XW, Li X, Li J, Lu MJ. Genetic variation of hepatitis B virus and its significance for pathogenesis. World J Gastroenterol. 2016;22(1):126-44. doi: 10.3748/wjg.v22.i1.126. [PubMed: 26755865]. [PubMed Central: PMC4698480].
  • 3. Behelgardi A, Hosseini SM, Mohebbi SR, Azimzadeh P, Derakhshani S, Karimi K, et al. a study on genetic association of interleukin-16 single nucleotide polymorphism (rs1131445) with chronic hepatitis B virus infection in Iranian patients. Jundishapur J Microbiol. 2015;8(11). e23411. doi: 10.5812/jjm.23411. [PubMed: 26855736]. [PubMed Central: PMC4735834].
  • 4. Ayub A, Ashfaq UA, Haque A. HBV induced HCC: major risk factors from genetic to molecular level. Biomed Res Int. 2013;2013:810461. doi: 10.1155/2013/810461. [PubMed: 23991421]. [PubMed Central: PMC3749539].
  • 5. Colombo M, Kuo G, Choo QL, Donato MF, Del Ninno E, Tommasini MA, et al. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet. 1989;2(8670):1006-8. doi: 10.1016/S0140-6736(89)91016-7. [PubMed: 2572740].
  • 6. Hajiani E, Masjedizadeh R, Hashemi J, Azmi M, Rajabi T. Risk factors for hepatocellular carcinoma in Southern Iran. Saudi Med J. 2005;26(6):974-7. [PubMed: 15983686].
  • 7. Milani S, Sharifi Z, Hosseini M, Shooshtari MM. Determination of HBV genotypes among HBs Ag positive blood donors in Tehran, Iran using PCR-RFLP. Iran J Publ Health. 2009;38(1):41-7.
  • 8. Poustchi H, Mohamadkhani A, Bowden S, Montazeri G, Ayres A, Revill P, et al. Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease. J Viral Hepat. 2008;15(10):753-60. doi: 10.1111/j.1365-2893.2008.00998.x. [PubMed: 18507754].
  • 9. Alavian SM, Keyvani H, Rezai M, Ashayeri N, Sadeghi HM. Preliminary report of hepatitis B virus genotype prevalence in Iran. World J Gastroenterol. 2006;12(32):5211-3. [PubMed: 16937535]. [PubMed Central: PMC4088022].
  • 10. Amini S, Mahmoodi MF, Andalibi S, Solati AA. Seroepidemiology of hepatitis B, delta and human immunodeficiency virus infections in Hamadan province, Iran: A population based study. J Trop Med Hyg. 1993;96(5):277-87. [PubMed: 8411302].
  • 11. Romani S, Hosseini SM, Mohebbi SR, Kazemian S, Derakhshani S, Khanyaghma M, et al. Interleukin-16 gene polymorphisms are considerable host genetic factors for patients' susceptibility to chronic hepatitis B infection. Hepat Res Treat. 2014;2014:790753. doi: 10.1155/2014/790753. [PubMed: 25692036]. [PubMed Central: PMC4322659].
  • 12. Pujol FH, Navas MC, Hainaut P, Chemin I. Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma. Cancer Lett. 2009;286(1):80-8. doi: 10.1016/j.canlet.2009.07.013. [PubMed: 19683385].
  • 13. Krugman S, Overby LR, Mushahwar IK, Ling CM, Frosner GG, Deinhardt F. Viral hepatitis, type B. Studies on natural history and prevention re-examined. N Engl J Med. 1979;300(3):101-6. doi: 10.1056/NEJM197901183000301. [PubMed: 758598].
  • 14. Hoofnagle JH, Di Bisceglie AM. Serologic diagnosis of acute and chronic viral hepatitis. Semin Liver Dis. 1991;11(2):73-83. doi: 10.1055/s-2008-1040426. [PubMed: 1909458].
  • 15. Khanizadeh S, Ravanshad M, Mohebbi S, Naghoosi H, Mousavinasab S, Romnani S, et al. Correlation between Polymorphism of-56 SNP (T/C) Interferon-γ Receptor 1 Gene and Chronic HBV Infection. Iran J virol. 2011;5(2):19-24. doi: 10.21859/isv.5.2.19.
  • 16. Zhu XL, Du T, Li JH, Lu LP, Guo XH, Gao JR, et al. Association of HLA-DQB1 gene polymorphisms with outcomes of HBV infection in Chinese Han population. Swiss Med Wkly. 2007;137(7-8):114-20. [PubMed: 17370149].
  • 17. Gao QJ, Liu DW, Zhang SY, Jia M, Wang LM, Wu LH, et al. Polymorphisms of some cytokines and chronic hepatitis B and C virus infection. World J Gastroenterol. 2009;15(44):5610-9. doi: 10.3748/wjg.15.5610. [PubMed: 19938203]. [PubMed Central: PMC2785066].
  • 18. Conde SR, Feitosa RN, Freitas FB, Hermes RB, Demachki S, Araujo MT, et al. Association of cytokine gene polymorphisms and serum concentrations with the outcome of chronic hepatitis B. Cytokine. 2013;61(3):940-4. doi: 10.1016/j.cyto.2013.01.004. [PubMed: 23395388].
  • 19. Korachi M, Ceran N, Adaleti R, Nigdelioglu A, Sokmen M. An association study of functional polymorphic genes IRF-1, IFNGR-1, and IFN-gamma with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C. Int J Infect Dis. 2013;17(1):e44-9. doi: 10.1016/j.ijid.2012.08.004. [PubMed: 23040881].
  • 20. Shimamura T, Fujisawa T, Husain SR, Kioi M, Nakajima A, Puri RK. Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 2008;181(7):4656-65. doi: 10.4049/jimmunol.181.7.4656. [PubMed: 18802068].
  • 21. Hussein YM, Ahmad AS, Ibrahem MM, Elsherbeny HM, Shalaby SM, El-Shal AS, et al. Interleukin 13 receptors as biochemical markers in atopic patients. J Investig Allergol Clin Immunol. 2011;21(2):101-7. [PubMed: 21462799].
  • 22. Mannon P, Reinisch W. Interleukin 13 and its role in gut defence and inflammation. Gut. 2012;61(12):1765-73. doi: 10.1136/gutjnl-2012-303461. [PubMed: 22942239].
  • 23. Junttila IS, Mizukami K, Dickensheets H, Meier-Schellersheim M, Yamane H, Donnelly RP, et al. Tuning sensitivity to IL-4 and IL-13: Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 2008;205(11):2595-608. doi: 10.1084/jem.20080452. [PubMed: 18852293]. [PubMed Central: PMC2571934].
  • 24. Seyfizadeh N, Seyfizadeh N, Gharibi T, Babaloo Z. Interleukin-13 as an important cytokine: A review on its roles in some human diseases. Acta Microbiol Immunol Hung. 2015;62(4):341-78. doi: 10.1556/030.62.2015.4.2. [PubMed: 26689873].
  • 25. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50(1):121-7. doi: 10.1002/ana.1032. [PubMed: 11456302].
  • 26. Zamani M, Mehri M, Kollaee A, Yenki P, Ghaffarpor M, Harirchian MH, et al. Pharmacogenetic study on the effect of rivastigmine on PS2 and APOE genes in Iranian Alzheimer patients. Dement Geriatr Cogn Dis Extra. 2011;1(1):180-9. doi: 10.1159/000329514. [PubMed: 22163243]. [PubMed Central: PMC3199882].
  • 27. Mansoori M, Golalipour M, Alizadeh S, Jahangirerad A, Khandozi SR, Fakharai H, et al. Genetic variation in the ABCB1 gene may lead to mRNA level chabge: Application to gastric cancer cases. Asian Pac J Cancer Prev. 2015;16(18):8467-71. doi: 10.7314/APJCP.2015.16.18.8467. [PubMed: 26745103].
  • 28. Haghighi A, Fathi D, Shahbazi M, Motahari MM, Friedman B. Identification of a c.601C>G mutation in the CCM1 gene in a kindred with multiple skin, spinal and cerebral cavernous malformations. J Neurol Sci. 2013;334(1-2):97-101. doi: 10.1016/j.jns.2013.07.2518. [PubMed: 24007869].
  • 29. Ugozzoli L, Wallace RB. Allele-specific polymerase chain reaction. Methods. 1991;2(1):42-8. doi: 10.1016/S1046-2023(05)80124-0.
  • 30. Thursz M. Genetic susceptibility in infectious diseases. Biotechnol Genet Eng Rev. 2000;17:253-64. doi: 10.1080/02648725.2000.10647994. [PubMed: 11255668].
  • 31. Grunhage F, Nattermann J. Viral hepatitis: Human genes that limit infection. Best Pract Res Clin Gastroenterol. 2010;24(5):709-23. doi: 10.1016/j.bpg.2010.07.009. [PubMed: 20955972].
  • 32. Mackay IR. Genetic susceptibility to chronic hepatitis B virus infection. J Gastroenterol Hepatol. 2006;21(7):1087-8. doi: 10.1111/j.1440-1746.2006.04430.x. [PubMed: 16824056].
  • 33. McNicholl JM, Downer MV, Udhayakumar V, Alper CA, Swerdlow DL. Host-pathogen interactions in emerging and re-emerging infectious diseases: a genomic perspective of tuberculosis, malaria, human immunodeficiency virus infection, hepatitis B, and cholera. Annu Rev Public Health. 2000;21:15-46. doi: 10.1146/annurev.publhealth.21.1.15. [PubMed: 10884944].
  • 34. Thursz MR. Host genetic factors influencing the outcome of hepatitis. J Viral Hepat. 1997;4(4):215-20. doi: 10.1046/j.1365-2893.1997.00052.x. [PubMed: 9278218].
  • 35. Thursz M, Yee L, Khakoo S. Understanding the host genetics of chronic hepatitis B and C. Semin Liver Dis. 2011;31(2):115-27. doi: 10.1055/s-0031-1276642. [PubMed: 21538279].
  • 36. Tuncbilek S. Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection. World J Gastroenterol. 2014;20(20):6226-35. doi: 10.3748/wjg.v20.i20.6226. [PubMed: 24876743]. [PubMed Central: PMC4033460].
  • 37. Thursz M. Genetic susceptibility in chronic viral hepatitis. Antiviral Res. 2001;52(2):113-6. doi: 10.1016/S0166-3542(01)00175-9. [PubMed: 11672820].
  • 38. Lin TM, Chen CJ, Wu MM, Yang CS, Chen JS, Lin CC, et al. Hepatitis B virus markers in Chinese twins. Anticancer Res. 1989;9(3):737-41. [PubMed: 2764519].
  • 39. Wang L, Wu XP, Zhang W, Zhu DH, Wang Y, Li YP, et al. Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: Two independent case-control studies. PLoS One. 2011;6(3). e17608. doi: 10.1371/journal.pone.0017608. [PubMed: 21408128]. [PubMed Central: PMC3050917].
  • 40. de Andrade DR Jr, de Andrade DR. The influence of the human genome on chronic viral hepatitis outcome. Rev Inst Med Trop Sao Paulo. 2004;46(3):119-26. doi: 10.1590/S0036-46652004000300001. [PubMed: 15286811].
  • 41. Borzooy Z, Streinu-Cercel A, Mirshafiey A, Khamseh A, Mahmoudie MK, Navabi SS, et al. IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers. Germs. 2016;6(1):14-20. doi: 10.11599/germs.2016.1084. [PubMed: 27019828]. [PubMed Central: PMC4788777].
  • 42. Sun Y, Lu Y, Xie L, Deng Y, Li S, Qin X. Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population. Cancer Cell Int. 2015;15:35. doi: 10.1186/s12935-015-0184-2. [PubMed: 25861244]. [PubMed Central: PMC4389711].
  • 43. de Oliveira LC, Goldberg AC, Marin ML, Schneidwind KR, Frade AF, Kalil J, et al. Autoimmune hepatitis in Brazilian children: IgE and genetic polymorphisms in associated genes. J Immunol Res. 2015;2015:679813. doi: 10.1155/2015/679813. [PubMed: 26693492]. [PubMed Central: PMC4674601].
  • 44. Chakravarty R. Host genetic factors in hepatitis B virus infection. Int J Hum Genetics. 2005;5(1:33-6. doi: 10.1080/09723757.2005.11885913.
  • 45. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Daneshmandi S, Shamsizadeh A, et al. Non-association of IL-12 +1188 and IFN-gamma +874 polymorphisms with cytokines serum level in occult HBV infected patients. Saudi J Gastroenterol. 2011;17(1):30-5. doi: 10.4103/1319-3767.74461. [PubMed: 21196650]. [PubMed Central: PMC3099077].
  • 46. Alavian SM, Hajarizadeh B, Ahmadzad-Asl M, Kabir A, Bagheri-Lankarani K. Hepatitis B Virus infection in Iran: A systematic review. Hepat Mon. 2008;8(4):281-94.
  • 47. Abdolmohammadi R, Shahbazi Azar S, Khosravi A, Shahbazi M. CCR5 polymorphism as a protective factor for hepatocellular carcinoma in hepatitis B virus-infected Iranian patients. Asian Pac J Cancer Prev. 2016;17(10):4643-6. [PubMed: 27892677]. [PubMed Central: PMC5454610].
  • 48. Attar M, Azar SS, Shahbazi M. Interleukin-6-174 promoter polymorphism and susceptibility to hepatitis B virus infection as a risk factor for hepatocellular carcinoma in Iran. Asian Pac J Cancer Prev. 2016;17(5):2395-9. [PubMed: 27268603].
  • 49. Azar SS, Mansoori M, Attar M, Shahbazi M. Tumor necrosis factor alpha 308 G/A single nucleotide polymorphism and susceptibility to hepatocellular carcinoma via hepatitis B infection. Asian Pac J Cancer Prev. 2016;17(7):3381-4. [PubMed: 27509979].
  • 50. Ghasemian R, Babamahmoodi F, Ahangarkani F. Hepatitis A is a health hazard for iranian pilgrims who go to Holly Karbala: A preliminary report. Hepat Mon. 2016;16(6). e38138. doi: 10.5812/hepatmon.38138. [PubMed: 27630729]. [PubMed Central: PMC5011296].
  • 51. Ghasemian N, Shahbazi M. Interferon gamma gene polymorphism (+874 T > A) and chronic hepatitis B in the population of Gorgan, North-Eastern Iran. Jundishapur J Microbiol. 2016;9(8). e33639. doi: 10.5812/jjm.33639. [PubMed: 27800132]. [PubMed Central: PMC5080914].
  • 52. Su T, Mi Y, Zhang L, Wang S, Lu H, Shi L, et al. Association between IL13 gene polymorphisms and susceptibility to cancer: A meta-analysis. Gene. 2013;515(1):56-61. doi: 10.1016/j.gene.2012.11.035. [PubMed: 23246181].
  • 53. Sun G, Wang X, Shi L, Yue X, Fu L, Chen C, et al. Association between polymorphisms in interleukin-4Ralpha and interleukin-13 and glioma risk: A meta-analysis. Cancer Epidemiol. 2013;37(3):306-10. doi: 10.1016/j.canep.2013.01.003. [PubMed: 23395224].
  • 54. Sainz J, Rudolph A, Hoffmeister M, Frank B, Brenner H, Chang-Claude J, et al. Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk. J Clin Endocrinol Metab. 2012;97(5):E845-51. doi: 10.1210/jc.2011-2565. [PubMed: 22419714].
  • 55. Chu H, Ma L, Wang M, Shi D, Qin C, Yuan L, et al. The polymorphisms of IL-4, IL-4R and IL-13 genes and bladder cancer risk in a Chinese population: A case-control study. Mol Biol Rep. 2012;39(5):5349-57. doi: 10.1007/s11033-011-1334-9. [PubMed: 22170601].
  • 56. Deng Y, Xie M, Xie L, Wang J, Li T, He Y, et al. Association between polymorphism of the interleukin-13 gene and susceptibility to hepatocellular carcinoma in the Chinese population. PLoS One. 2015;10(2). e0116682. doi: 10.1371/journal.pone.0116682. [PubMed: 25658755]. [PubMed Central: PMC4319784].

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