Jundishapur Journal of Microbiology

Published by: Kowsar

Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection

Damian David Cifuentes Castaneda 1 , Ninfa Ramirez Duran 2 , Iliana Espinoza Rivera 3 , Luz Marcela Caro Gonzalez 3 , Martin Pablo Antonio Moreno Perez 2 and Hugo Mendieta Zeron 2 , 3 , 4 , *
Authors Information
1 Institucion Universitaria Colegio Mayor de Antioquia
2 Faculty of Medicine, Autonomous University of the State of Mexico
3 “Monica Pretelini Saenz” Maternal-Perinatal Hospital
4 Latin American Scientific Assoiciation A.C. (ASCILA)
Article information
  • Jundishapur Journal of Microbiology: March 2018, 11 (3); e62393
  • Published Online: February 13, 2018
  • Article Type: Brief Report
  • Received: October 2, 2017
  • Revised: December 2, 2017
  • Accepted: January 4, 2018
  • DOI: 10.5812/jjm.62393

To Cite: Cifuentes Castaneda D D, Ramirez Duran N, Espinoza Rivera I, Marcela Caro Gonzalez L, Pablo Antonio Moreno Perez M, et al. Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection, Jundishapur J Microbiol. 2018 ; 11(3):e62393. doi: 10.5812/jjm.62393.

Copyright © 2018, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusion
  • 1. Stoesser N, Moore CE, Pocock JM, An KP, Emary K, Carter M, et al. Pediatric bloodstream infections in Cambodia, 2007 to 2011. Pediatr Infect Dis J. 2013;32(7):272-6. doi: 10.1097/INF.0b013e31828ba7c6. [PubMed: 23838788].
  • 2. Sankar MJ, Neogi SB, Sharma J, Chauhan M, Srivastava R, Prabhakar PK, et al. State of newborn health in India. J Perinatol. 2016;36(s3):S3-8. doi: 10.1038/jp.2016.183. [PubMed: 27924104].
  • 3. Vasaikar S, Obi L, Morobe I, Bisi-Johnson M. Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa. Int J Microbiol. 2017;2017:8486742. doi: 10.1155/2017/8486742. [PubMed: 28250772].
  • 4. Brisse S, Verhoef J. Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. Int J Syst Evol Microbiol. 2001;51(Pt 3):915-24. doi: 10.1099/00207713-51-3-915. [PubMed: 11411715].
  • 5. Haeggman S, Lofdahl S, Paauw A, Verhoef J, Brisse S. Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004;48(7):2400-8. doi: 10.1128/AAC.48.7.2400-2408.2004. [PubMed: 15215087].
  • 6. Chen M, Li Y, Li S, Tang L, Zheng J, An Q. Genomic identification of nitrogen-fixing Klebsiella variicola, K. pneumoniae and K. quasipneumoniae. J Basic Microbiol. 2016;56(1):78-84. doi: 10.1002/jobm.201500415. [PubMed: 26471769].
  • 7. Schulz-Stubner S, Kniehl E. Transmission of extended-spectrum beta-lactamase Klebsiella oxytoca via the breathing circuit of a transport ventilator: root cause analysis and infection control recommendations. Infect Control Hosp Epidemiol. 2011;32(8):828-9. doi: 10.1086/661225. [PubMed: 21768772].
  • 8. Lowe C, Willey B, O'Shaughnessy A, Lee W, Lum M, Pike K, et al. Outbreak of extended-spectrum beta-lactamase-producing Klebsiella oxytoca infections associated with contaminated handwashing sinks(1). Emerg Infect Dis. 2012;18(8):1242-7. doi: 10.3201/eid1808.111268. [PubMed: 22841005].
  • 9. Fujita A, Kimura K, Yokoyama S, Jin W, Wachino J, Yamada K, et al. Characterization of Piperacillin/Tazobactam-Resistant Klebsiella oxytoca Recovered from a Nosocomial Outbreak. PLoS One. 2015;10(11):142366. doi: 10.1371/journal.pone.0142366. [PubMed: 26539828].
  • 10. Leitner E, Zarfel G, Luxner J, Herzog K, Pekard-Amenitsch S, Hoenigl M, et al. Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward. Antimicrob Agents Chemother. 2015;59(1):714-6. doi: 10.1128/AAC.04306-14. [PubMed: 25348541].
  • 11. Guy R, Geoghegan L, Heginbothom M, Howe R, Muller-Pebody B, Reilly JS, et al. Non-susceptibility of Escherichia coli, Klebsiella spp., Pseudomonas spp., Streptococcus pneumoniae and Staphylococcus aureus in the UK: temporal trends in England, Northern Ireland, Scotland and Wales. J Antimicrob Chemother. 2016;71(6):1564-9. doi: 10.1093/jac/dkw018. [PubMed: 26892779].
  • 12. Moradigaravand D, Martin V, Peacock SJ, Parkhill J. Population structure of multidrug resistant Klebsiella oxytoca within hospitals across the UK and Ireland identifies sharing of virulence and resistance genes with K. pneumoniae. Genome Biol Evol. 2017. doi: 10.1093/gbe/evx019. [PubMed: 28177070].
  • 13. Taneja N, Sharma M. ESBLs detection in clinical microbiology: why & how?. Indian J Med Res. 2008;127(4):297-300. [PubMed: 18577783].
  • 14. Tariq TM, Rasool E. Emerging Trends of Bloodstream Infections: A Six-Year Study at a Paediatric Tertiary Care Hospital in Kabul. J Coll Physicians Surg Pak. 2016;26(11):887-91. [PubMed: 27981921].
  • 15. Seki M, Gotoh K, Nakamura S, Akeda Y, Yoshii T, Miyaguchi S, et al. Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system. J Med Microbiol. 2013;62(Pt 5):801-3. doi: 10.1099/jmm.0.051334-0. [PubMed: 23449877].
  • 16. Fonseca EL, Ramos ND, Andrade BG, Morais LL, Marin MF, Vicente AC. A one-step multiplex PCR to identify Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae in the clinical routine. Diagn Microbiol Infect Dis. 2017;87(4):315-7. doi: 10.1016/j.diagmicrobio.2017.01.005. [PubMed: 28139276].
  • 17. Brisse S, Passet V, Grimont PA. Description of Klebsiella quasipneumoniae sp. nov., isolated from human infections, with two subspecies, Klebsiella quasipneumoniae subsp. quasipneumoniae subsp. nov. and Klebsiella quasipneumoniae subsp. similipneumoniae subsp. nov., and demonstration that Klebsiella singaporensis is a junior heterotypic synonym of Klebsiella variicola. Int J Syst Evol Microbiol. 2014;64(Pt 9):3146-52. doi: 10.1099/ijs.0.062737-0. [PubMed: 24958762].
  • 18. Garza-Ramos U, Silva-Sanchez J, Martinez-Romero E, Tinoco P, Pina-Gonzales M, Barrios H, et al. Development of a multiplex-PCR probe system for the proper identification of Klebsiella variicola. BMC Microbiol. 2015;15:64. doi: 10.1186/s12866-015-0396-6. [PubMed: 25886267].
  • 19. Maatallah M, Vading M, Kabir MH, Bakhrouf A, Kalin M, Naucler P, et al. Klebsiella variicola is a frequent cause of bloodstream infection in the stockholm area, and associated with higher mortality compared to K. pneumoniae. PLoS One. 2014;9(11):113539. doi: 10.1371/journal.pone.0113539. [PubMed: 25426853].
  • 20. Dong H, Cao H, Zheng H. Pathogenic bacteria distributions and drug resistance analysis in 96 cases of neonatal sepsis. BMC Pediatr. 2017;17(1):44. doi: 10.1186/s12887-017-0789-9. [PubMed: 28143490].
  • 21. Levy Hara G, Gould I, Endimiani A, Pardo PR, Daikos G, Hsueh PR, et al. Detection, treatment, and prevention of carbapenemase-producing Enterobacteriaceae: recommendations from an International Working Group. J Chemother. 2013;25(3):129-40. doi: 10.1179/1973947812Y.0000000062. [PubMed: 23783137].
  • 22. Dark PM, Dean P, Warhurst G. Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care. 2009;13(4):217. doi: 10.1186/cc7886. [PubMed: 19664174].
  • 23. Silva-Junior WP, Martins AS, Xavier PC, Appel KL, Oliveira Junior SA, Palhares DB. Etiological profile of early neonatal bacterial sepsis by multiplex qPCR. J Infect Dev Ctries. 2016;10(12):1318-24. doi: 10.3855/jidc.7474. [PubMed: 28036311].
  • 24. Layton Tovar CF, Cuevas Ya-ez E, Velasco Montejo B, Mendieta Zeron H. Susceptibility of Candida albicans ATCC 10231 to TETRAHIDROFURANOSIL-1, 2, 3-TRIAZOLES obtained by "Via click" with evaluation of the sensititre yeast one and yeast microdilution methods. Rev Boliv Quim. 2014;31(1):15-21.
  • 25. Jasani B, Kannan S, Nanavati R, Gogtay NJ, Thatte U. An audit of colistin use in neonatal sepsis from a tertiary care centre of a resource-limited country. Indian J Med Res. 2016;144(3):433-9. doi: 10.4103/0971-5916.198682. [PubMed: 28139542].
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