Jundishapur Journal of Microbiology

Published by: Kowsar

Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

Mohsen Azizi 1 , Seyed Hamidreza Mortazavi 2 , Misagh Etemadimajed 3 , Simin Gheini 4 , Siavash Vaziri 5 , Amirhooshang Alvandi 6 , Mahsa Kashef 1 and Kamal Ahmadi 1 , *
Authors Information
1 Research Assistant, MSc in Medical Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Pediatric Immunologist and Allergist, Assistant Professor of Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Pediatrician, Assistant Professor of Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Associate Professor of Infection Disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
6 Associate Professor, Department of Medical Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Article information
  • Jundishapur Journal of Microbiology: December 2017, 10 (12); e61522
  • Published Online: November 21, 2017
  • Article Type: Research Article
  • Received: April 8, 2017
  • Revised: September 10, 2017
  • Accepted: September 26, 2017
  • DOI: 10.5812/jjm.61522

To Cite: Azizi M, Mortazavi S H, Etemadimajed M, Gheini S, Vaziri S, et al. Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran, Jundishapur J Microbiol. 2017 ; 10(12):e61522. doi: 10.5812/jjm.61522.

Copyright © 2017, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusion
  • 1. Dent LL, Marshall DR, Pratap S, Hulette RB. Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital. BMC Infect Dis. 2010; 10: 196[DOI][PubMed]
  • 2. Jeon BC, Jeong SH, Bae IK, Kwon SB, Lee K, Young D, et al. Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 beta-lactamase in korea. J Clin Microbiol. 2005; 43(5): 2241-5[DOI][PubMed]
  • 3. Ellis D, Cohen B, Liu J, Larson E. Risk factors for hospital-acquired antimicrobial-resistant infection caused by Acinetobacter baumannii. Antimicrob Resist Infect Control. 2015; 4: 40[DOI][PubMed]
  • 4. Michalopoulos A, Falagas ME. Treatment of Acinetobacter infections. Expert Opin Pharmacother. 2010; 11(5): 779-88[DOI][PubMed]
  • 5. Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis. 2006; 42(5): 692-9[DOI][PubMed]
  • 6. Izadpour F, Ranjbari N, Aramesh MR, Moosavian M, ShahAli S, Larki F, et al. An Investigation of Antibacterial Resistance Patterns Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates Collected from Intensive Care Units of a University-Affiliated Hospital in Ahvaz, Iran. Jundishapur J Microbiol. 2016; 9(8)[DOI][PubMed]
  • 7. Zamani K, Emami A, Bazargani A, Moattari A. Phenotypic and molecular characterization of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli isolates in Shiraz, Iran. Rev Soc Bras Med Trop. 2015; 48(4): 479-82[DOI][PubMed]
  • 8. Oteo J, Perez-Vazquez M, Campos J. Extended-spectrum [beta]-lactamase producing Escherichia coli: changing epidemiology and clinical impact. Curr Opin Infect Dis. 2010; 23(4): 320-6[DOI][PubMed]
  • 9. Paterson DL. Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs). Clin Microbiol Infect. 2000; 6(9): 460-3[PubMed]
  • 10. Rawat D, Nair D. Extended-spectrum beta-lactamases in Gram Negative Bacteria. J Glob Infect Dis. 2010; 2(3): 263-74[DOI][PubMed]
  • 11. Turton JF, Woodford N, Glover J, Yarde S, Kaufmann ME, Pitt TL. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. J Clin Microbiol. 2006; 44(8): 2974-6[DOI][PubMed]
  • 12. Clinical and Laboratory Standards Institute . Performance standards for antimicrobial susceptibility testing; Twenty-fourth informational supplement (M100 S24). 2014;
  • 13. Ahanjan M, Kholdi S, Rafiei A. Antibiotic-resistance patterns and frequency of TEM and CTX type extended-spectrum β-lactamases in acinetobacter clinical isolates [In Persian]. J Mazandaran Univ Med Sci. 2014; 24(116): 32-40
  • 14. Safari M, Mozaffari Nejad AS, Bahador A, Jafari R, Alikhani MY. Prevalence of ESBL and MBL encoding genes in Acinetobacter baumannii strains isolated from patients of intensive care units (ICU). Saudi J Biol Sci. 2015; 22(4): 424-9[DOI][PubMed]
  • 15. Farajnia S, Azhari F, Alikhani MY, Hosseini MK, Peymani A, Sohrabi N. Prevalence of PER and VEB Type Extended Spectrum Betalactamases among Multidrug Resistant Acinetobacter baumannii Isolates in North-West of Iran. Iran J Basic Med Sci. 2013; 16(6): 751-5[PubMed]
  • 16. Sinha M, Srinivasa H, Macaden R. Antibiotic resistance profile & extended spectrum beta-lactamase (ESBL) production in Acinetobacter species. Indian J Med Res. 2007; 126(1): 63-7[PubMed]
  • 17. Vazirzadeh J, Ghajavand H, Heidari L, Behshood P. Prevalence of extended spectrum beta lactamases (ESBLs) and antibiotic resistance pattern acinetobacter baumannii strains isolated from clinical specimens in Isfahan City, Iran [In Persian]. Med Lab J. 2015; 9(3): 32-9
  • 18. Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Aldisio E, Marchese AE, et al. Antibiotic trends of Klebsiella pneumoniae and Acinetobacter baumannii resistance indicators in an intensive care unit of Southern Italy, 2008-2013. Antimicrob Resist Infect Control. 2015; 4: 43[DOI][PubMed]
  • 19. Mirnejad R, Vafaei S. Antibiotic resistance patterns and the prevalence of ESBLs among strains of Acinetobacter baumannii isolated from clinical specimens. J Gen Microbes Immunity. 2013; 2013: 1-8[DOI]
  • 20. Kheltabadi RF, Moniri R, Shajari GR, Nazem Shirazi MH, Musavi SGA, Ghasemi A, et al. Antimicrobial susceptibility patterns and the distribution of resistance genes among acinetobacter species isolated from patients in shahid Beheshti hospital, Kashan. Feyz J Kashan Univ Med Sci. 2009; 12(4)
  • 21. Khalilzadegan S, Sade M, Godarzi H, Eslami G, Hallajzade M, Fallah F, et al. Beta-Lactamase Encoded Genes blaTEM and blaCTX Among Acinetobacter baumannii Species Isolated From Medical Devices of Intensive Care Units in Tehran Hospitals. Jundishapur J Microbiol. 2016; 9(5)[DOI][PubMed]
  • 22. Shakibaie MR, Adeli S, Salehi MH. Antibiotic resistance patterns and extended-spectrum beta-lactamase production among Acinetobacter spp. isolated from an intensive care Unit of a hospital in Kerman, Iran. Antimicrob Resist Infect Control. 2012; 1(1): 1[DOI][PubMed]
  • 23. Hujer KM, Hujer AM, Hulten EA, Bajaksouzian S, Adams JM, Donskey CJ, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006; 50(12): 4114-23[DOI][PubMed]
  • 24. Ribera A, Vila J, Fernandez-Cuenca F, Martinez-Martinez L, Pascual A, Beceiro A, et al. Type 1 integrons in epidemiologically unrelated Acinetobacter baumannii isolates collected at Spanish hospitals. Antimicrob Agents Chemother. 2004; 48(1): 364-5[DOI][PubMed]
  • 25. Gupta V, Garg R, Garg S, Chander J, Attri AK. Coexistence of Extended Spectrum Beta-Lactamases, AmpC Beta-Lactamases and Metallo-Beta-Lactamases in Acinetobacter baumannii from burns patients: a report from a tertiary care centre of India. Ann Burns Fire Disasters. 2013; 26(4): 189-92[PubMed]
  • 26. Shrivastava G, Bajpai T, Bhatambare GS, Patel KB. Sensitivity profile of multidrug resistant Acinetobacter Spp. isolated at ICUs of tertiary care hospital. Int J Health Sys Disaster Manag. 2013; 1(4): 200[DOI]
  • 27. Banerjee M, Chaudhary B, Shukla S. Prevalence of ESBL and MBL in acinetobacter species isolated from clinical samples in tertiary care hospital. Int J Sci Res. 2015; 4(6): 1183-6
  • 28. Alyamani EJ, Khiyami MA, Booq RY, Alnafjan BM, Altammami MA, Bahwerth FS. Molecular characterization of extended-spectrum beta-lactamases (ESBLs) produced by clinical isolates of Acinetobacter baumannii in Saudi Arabia. Ann Clin Microbiol Antimicrob. 2015; 14: 38[DOI][PubMed]
  • 29. AL-Thahab AA. Molecular detection of extended-spectrum beta-lactamases in clinical isolates of Acinetobacter baumannii. J Biol Agric Healthc. 2013; 3(7): 32-9
  • 30. Huang ZM, Mao PH, Chen Y, Wu L, Wu J. [Study on the molecular epidemiology of SHV type beta-lactamase-encoding genes of multiple-drug-resistant acinetobacter baumannii]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25(5): 425-7[PubMed]
  • 31. Jain A, Mondal R. TEM & SHV genes in extended spectrum beta-lactamase producing Klebsiella species beta their antimicrobial resistance pattern. Indian J Med Res. 2008; 128(6): 759-64[PubMed]
  • 32. Feiz Sardhar MH, Akya A. The frequency of extended spectrum β-lactamase genes of SHV-2a, SHV-5 and SHV-12 in clinical isolates of klebsiella pneumoniae isolated from Kermanshah medical centers in 2014. J Arak Univ Med Sci. 2016; 19(107): 59-67
  • 33. Sedighi I, Arabestani MR, Rahimbakhsh A, Karimitabar Z, Alikhani MY. Dissemination of Extended-Spectrum beta-Lactamases and Quinolone Resistance Genes Among Clinical Isolates of Uropathogenic Escherichia coli in Children. Jundishapur J Microbiol. 2015; 8(7)[DOI][PubMed]
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