Jundishapur Journal of Microbiology

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Evaluation of APR1 Gene Expression in Candida albicans Strains Isolated From Patients With Multiple Sclerosis

Shahla Amri Saroukolaei 1 , Mojdeh Ghabaee 2 , Hojjatollah Shokri 3 , * , Alireza Khosravi 4 and Alireza Badiei 5
Authors Information
1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra Malaysia, Selangor, Malaysia
2 Neurology Department, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, IR Iran
3 Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, IR Iran
4 Mycology Research Centre, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran
5 Department of Pathology, University of Otago, Christchurch, New Zealand
Article information
  • Jundishapur Journal of Microbiology: May 2016, 9 (5); e60074
  • Published Online: April 9, 2016
  • Article Type: Research Article
  • Received: September 20, 2015
  • Revised: January 23, 2016
  • Accepted: February 12, 2016
  • DOI: 10.5812/jjm.33292

To Cite: Amri Saroukolaei S, Ghabaee M, Shokri H, Khosravi A, Badiei A. Evaluation of APR1 Gene Expression in Candida albicans Strains Isolated From Patients With Multiple Sclerosis, Jundishapur J Microbiol. 2016 ; 9(5):e60074. doi: 10.5812/jjm.33292.

Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Fridkin SK. The changing face of fungal infections in health care settings. Clin Infect Dis. 2005; 41(10): 1455-60[DOI][PubMed]
  • 2. Segal BH, Kwon-Chung J, Walsh TJ, Klein BS, Battiwalla M, Almyroudis NG, et al. Immunotherapy for fungal infections. Clin Infect Dis. 2006; 42(4): 507-15[DOI][PubMed]
  • 3. Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, et al. Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis. 2003; 37(9): 1172-7[DOI][PubMed]
  • 4. Morgan J, Meltzer MI, Plikaytis BD, Sofair AN, Huie-White S, Wilcox S, et al. Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance. Infect Control Hosp Epidemiol. 2005; 26(6): 540-7[DOI][PubMed]
  • 5. Wilson LS, Reyes CM, Stolpman M, Speckman J, Allen K, Beney J. The direct cost and incidence of systemic fungal infections. Value Health. 2002; 5(1): 26-34[DOI][PubMed]
  • 6. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007; 20(1): 133-63[DOI][PubMed]
  • 7. Parra-Ortega B, Cruz-Torres H, Villa-Tanaca L, Hernandez-Rodriguez C. Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species. Mem Inst Oswaldo Cruz. 2009; 104(3): 505-12[PubMed]
  • 8. Naglik JR, Challacombe SJ, Hube B. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev. 2003; 67(3): 400-28[PubMed]
  • 9. Salome L, Berenice P, Consuelo B, Cesar C, Hugo HC, Lourdes V. The proteolytic system of Candida dubliniensis. Am J Infect Dis. 2007; 3(2): 76-83[DOI]
  • 10. Mechler B, Wolf DH. Analysis of proteinase A function in yeast. Eur J Biochem. 1981; 121(1): 47-52[DOI]
  • 11. Enjalbert B, Nantel A, Whiteway M. Stress-induced gene expression in Candida albicans: absence of a general stress response. Mol Biol Cell. 2003; 14(4): 1460-7[DOI][PubMed]
  • 12. Amri Saroukolaei S, Shokri H, Aklilu E, Pei Pei C, Amini P, Badiei A, et al. Differential expression of the vacuolar aspartic proteinase (APR1) gene in Candida albicans strains isolated from Malaysian and Iranian human and mice blood. Afr J Microbiol Res. 2011; 6(9): 2150-5[DOI]
  • 13. Gilden DH. Infectious causes of multiple sclerosis. Lancet Neurol. 2005; 4(3): 195-202[DOI][PubMed]
  • 14. Ascherio A. Epstein-Barr virus in the development of multiple sclerosis. Expert Rev Neurother. 2008; 8(3): 331-3[DOI]
  • 15. Ascherio A, Munger K. Epidemiology of multiple sclerosis: from risk factors to prevention. Semin Neurol. 2008; 28(1): 17-28[DOI][PubMed]
  • 16. Contini C, Seraceni S, Cultrera R, Castellazzi M, Granieri E, Fainardi E. Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis. Mult Scler. 2008; 14(4): 564-6[DOI][PubMed]
  • 17. Lain A, Elguezabal N, Moragues MD, Garcia-Ruiz JC, del Palacio A, Ponton J. Contribution of serum biomarkers to the diagnosis of invasive candidiasis. Expert Rev Mol Diagn. 2008; 8(3): 315-25[DOI][PubMed]
  • 18. Benito-Leon J, Pisa D, Alonso R, Calleja P, Diaz-Sanchez M, Carrasco L. Association between multiple sclerosis and Candida species: evidence from a case-control study. Eur J Clin Microbiol Infect Dis. 2010; 29(9): 1139-45[DOI]
  • 19. Giovannoni G, Cutter GR, Lunemann J, Martin R, Munz C, Sriram S, et al. Infectious causes of multiple sclerosis. Lancet Neurol. 2006; 5(10): 887-94[DOI][PubMed]
  • 20. Fraga-Silva TFC, Mimura LAN, Marchetti CM, Minicucci FC, Franca TGD, Zorzella-Pezavento SFG, et al. Experimental autoimmune encephalomyelitis development is aggravated by Candida albicans infection. J Immunol Res. 2010; 2015: 1-11[DOI]
  • 21. Kurtzman C, Smiley M, Johnson C. Emendation of the genus Issatchenkia Kudriavzev and comparison of species by deoxyribonucleic acid reassociation, mating reaction, and ascospore ultrastructure. Int J Syst Evol Microbiol. 1980; 30(2): 503-13[DOI]
  • 22. Rogers PD, Barker KS. Evaluation of differential gene expression in fluconazole-susceptible and-resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob Agents Chemother. 2002; 46(11): 3412-7[DOI]
  • 23. Lipton SA, Hickey WF, Morris JH, Loscalzo J. Candidal infection in the central nervous system. Am J Med. 1984; 76(1): 101-8[DOI]
  • 24. Komeda T, Sakai Y, Kato N, Kondo K. Construction of proteinase-deficient Candida boidinii strains useful for recombinant rotein production: cloning and disruption of proteinase A gene (PEP4) and proteinase B gene (PRB1). Biosci Biotechnol Biochem J. 2002; 66(3): 628-31[DOI]
  • 25. Amri Saroukolaei S, Pei Pei C, Shokri H, Asadi F. Purification and comparison of intracellular proteinase A in Candida spp. isolates from Malaysian and Iranian patients and infected mice. J Mycol Med. 2012; 22(2): 149-59[DOI][PubMed]
  • 26. Castro M, Bjoraker JA, Rohrbach MS, Limper AH. Candida albicans induces the release of inflammatory mediators from human peripheral blood monocytes. Inflammation. 1996; 20(1): 107-22[PubMed]
  • 27. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 1995; 13(1): 251-76[DOI]
  • 28. Pisa D, Alonso R, Carrasco L. Fungal infection in a patient with multiple sclerosis. Eur J Clin Microbiol Infect Dis. 2011; 30(10): 1173-80[DOI][PubMed]
  • 29. Ghabaee M, Bayati A, Amri Saroukolaei S, Sahraian MA, Sanaati MH, Karimi P, et al. Analysis of HLA DR2&DQ6 (DRB1* 1501, DQA1* 0102, DQB1* 0602) haplotypes in Iranian patients with multiple sclerosis. Cell Mol Neurobiol. 2009; 29(1): 109-14[DOI]
  • 30. Fradin C, Kretschmar M, Nichterlein T, Gaillardin C, d'Enfert C, Hube B. Stage-specific gene expression of Candida albicans in human blood. Mol Microbiol. 2003; 47(6): 1523-43[PubMed]
  • 31. Chadeganipour M, Shadzi S, Dehghan P, Bijary J. The incidence of opportunistic fungi in patients suspected of tuberculosis. Mycoses. 2000; 43(7-8): 269-72[PubMed]
  • 32. Lenard ZM, Lester NV, O’hara AJ, Hopper BJ, Lester GD. Disseminated cryptococcosis including osteomyelitis in a horse. Aust Vet J. 2007; 85(1‐2): 51-5[DOI]
  • 33. Ramos M, Pisa D, Molina S, Rabano A, Juarranz A, Carrasco L. Fungal infection in patients with multiple sclerosis. Open Mycol J. 2008; 2(1): 22-8[DOI]
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