Jundishapur Journal of Microbiology

Published by: Kowsar

Molecular Investigation of the Transmission Dynamics of Brucellosis Observed Among Children in the Province of South - East Anatolia, Turkey

Tuba Dal 1 , * , Riza Durmaz 1 , Ali Ceylan 2 , Fatma Bacalan 3 , Alper Karagoz 4 , Bekir Celebi 4 , Ekrem Yasar 5 , Selcuk Kilic 4 and Cibali Acikgoz 1
Authors Information
1 Department of Medical Microbiology, Ankara Yildirim Beyazit University, School of Medicine, Ankara, Turkey
2 Department of Public Health, Dicle University, School of Medicine, Diyarbakir, Turkey
3 Diyarbakir Pediatric Hospital, Microbiology Laboratory, Diyarbakir, Turkey
4 Public Health Agency of Turkey
5 Memorial Dicle Hospital, Diyarbakir, Turkey
Article information
  • Jundishapur Journal of Microbiology: March 2018, 11 (3); e58857
  • Published Online: February 20, 2018
  • Article Type: Research Article
  • Received: October 2, 2017
  • Revised: December 21, 2017
  • Accepted: January 30, 2018
  • DOI: 10.5812/jjm.58857

To Cite: Dal T, Durmaz R, Ceylan A, Bacalan F, Karagoz A, et al. Molecular Investigation of the Transmission Dynamics of Brucellosis Observed Among Children in the Province of South - East Anatolia, Turkey, Jundishapur J Microbiol. 2018 ; 11(3):e58857. doi: 10.5812/jjm.58857.

Copyright © 2018, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusion
  • 1. Njeru J, Wareth G, Melzer F, Henning K, Pletz MW, Heller R, et al. Systematic review of brucellosis in Kenya: disease frequency in humans and animals and risk factors for human infection. BMC Public Health. 2016;16(1):853. doi: 10.1186/s12889-016-3532-9. [PubMed: 27549329].
  • 2. Musallam ,I, Abo-Shehada MN, Hegazy YM, Holt HR, Guitian FJ. Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection. Epidemiol Infect. 2016;144(4):671-85. doi: 10.1017/S0950268815002575. [PubMed: 26508323].
  • 3. Dal T, Celen MK, Ayaz C, Dal MS, Kalkanli S, Mert D, et al. Brucellosis a major problem: A five years experience. Acta Medica Mediterranea. 2013;164(9):665-70.
  • 4. Dulger AC, Aslan M, Ceylan MR, Olmez S, Karadas S, Akdeniz H. The Syndrome of Inappropriate Secretion of AntiDiuretic Hormone in Patients With Brucellosis. J Clin Lab Anal. 2015;29(5):366-9. doi: 10.1002/jcla.21780. [PubMed: 24889373].
  • 5. Hacimustafaoglu MK. Brucellosis. J Curr Pediatr. 2014;2:39-43.
  • 6. Hasim O, Dalgic N. A Clinical and Laboratory Evaluation of 32 Cases of Brucellosis. Cocuk Enfeksiyon Dergisi/Journal of Pediatric Infection. 2013;7(2):61-7. doi: 10.5152/ced.2013.17.
  • 7. Guler S, Kokoglu OF, Ucmak H, Gul M, Ozden S, Ozkan F. Human brucellosis in Turkey: different clinical presentations. J Infect Dev Ctries. 2014;8(5):581-8. doi: 10.3855/jidc.3510. [PubMed: 24820461].
  • 8. Karadag-Oncel E, Ozsurekci Y, Cengiz AB, Kara A, Ceyhan M, Celik M, et al. Cocukluk cagında bruselloz: Hacettepe Universitesi deneyimi. Cocuk Sagligi ve Hastaliklari Dergisi. 2011;54:135-41.
  • 9. Sari E, Sari I, Say A, Guven F, Ulutas A. The evaluation of brucellosis in children in an endemic region of Turkey, Van. Gaziantep Medical Journal. 2013;19(1):1. doi: 10.5455/gmj-30-2012-111.
  • 10. Garofolo G, Di Giannatale E, De Massis F, Zilli K, Ancora M, Camma C, et al. Investigating genetic diversity of Brucella abortus and Brucella melitensis in Italy with MLVA-16. Infect Genet Evol. 2013;19:59-70. doi: 10.1016/j.meegid.2013.06.021. [PubMed: 23831636].
  • 11. Kilic S, Ivanov IN, Durmaz R, Bayraktar MR, Ayaslioglu E, Uyanik MH, et al. Multiple-locus variable-number tandem-repeat analysis genotyping of human Brucella isolates from Turkey. J Clin Microbiol. 2011;49(9):3276-83. doi: 10.1128/JCM.02538-10. [PubMed: 21795514].
  • 12. Parlak M, Guducuoglu H, Bayram Y, Cikman A, Aypak C, Kilic S, et al. Identification and determination of antibiotic susceptibilities of Brucella strains isolated from patients in van, Turkey by conventional and molecular methods. Int J Med Sci. 2013;10(10):1406-11. doi: 10.7150/ijms.6565. [PubMed: 23983603].
  • 13. Gur D, Kocagoz S, Akova M, Unal S. Comparison of E test to microdilution for determining in vitro activities of antibiotics against Brucella melitensis. Antimicrob Agents Chemother. 1999;43(9):2337.
  • 14. CLSI CALSI. M100/S24 Performance standards for antimicrobial susceptibility testing; twenty-fourth information supplement. 34. 2014.
  • 15. Tygacil. Highlights of prescribing information. 2017, [cited Oct]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021821s021lbl.pdf.
  • 16. Probert WS, Schrader KN, Khuong NY, Bystrom SL, Graves MH. Real-time multiplex PCR assay for detection of Brucella spp., B. abortus, and B. melitensis. J Clin Microbiol. 2004;42(3):1290-3. [PubMed: 15004098].
  • 17. Le Fleche P, Jacques I, Grayon M, Al Dahouk S, Bouchon P, Denoeud F, et al. Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay. BMC Microbiol. 2006;6:9. doi: 10.1186/1471-2180-6-9. [PubMed: 16469109].
  • 18. Al Dahouk S, Fleche PL, Nockler K, Jacques I, Grayon M, Scholz HC, et al. Evaluation of Brucella MLVA typing for human brucellosis. J Microbiol Methods. 2007;69(1):137-45. doi: 10.1016/j.mimet.2006.12.015. [PubMed: 17261338].
  • 19. Abuhandan M, Guzel B, Cakmak A, Cicek A. Pediatric Brucellosis: A Retrospective Evaluation of 82 Cases - Original Investigation. Cocuk Enfeksiyon Dergisi/Journal of Pediatric Infection. 2012;6(3):74-8. doi: 10.5152/ced.2012.24.
  • 20. Menshawy AM, Perez-Sancho M, Garcia-Seco T, Hosein HI, Garcia N, Martinez I, et al. Assessment of genetic diversity of zoonotic Brucella spp. recovered from livestock in Egypt using multiple locus VNTR analysis. Biomed Res Int. 2014;2014:353876. doi: 10.1155/2014/353876. [PubMed: 24511531].
  • 21. Zhang F, Li Z, La X, Ma X, Zhang Y, Ji P, et al. Multiple-locus variable-number tandem-repeat analysis of Brucella isolates from patients in Xinjiang China. Int J Clin Exp Med. 2015;8(9):15716-23. [PubMed: 26629067].
  • 22. Shevtsov A, Ramanculov E, Shevtsova E, Kairzhanova A, Tarlykov P, Filipenko M, et al. Genetic diversity of Brucella abortus and Brucella melitensis in Kazakhstan using MLVA-16. Infect Genet Evol. 2015;34:173-80. doi: 10.1016/j.meegid.2015.07.008. [PubMed: 26160544].
  • 23. Mustafa AS, Habibi N, Osman A, Shaheed F, Khan MW. Species identification and molecular typing of human Brucella isolates from Kuwait. PLoS One. 2017;12(8):182111. doi: 10.1371/journal.pone.0182111. [PubMed: 28800594].
  • 24. Alavi SM, Alavi L. Treatment of brucellosis: a systematic review of studies in recent twenty years. Caspian J Intern Med. 2013;4(2):636-41. [PubMed: 24009951].
  • 25. Eskazan AE, Dal MS, Kaya S, Dal T, Ayyildiz O, Soysal T. Two cases of autoimmune hemolytic anemia secondary to brucellosis: a review of hemolytic disorders in patients with brucellosis. Intern Med. 2014;53(11):1153-8. [PubMed: 24881740].
  • 26. Bayram Y, Korkoca H, Aypak C, Parlak M, Cikman A, Kilic S, et al. Antimicrobial susceptibilities of Brucella isolates from various clinical specimens. Int J Med Sci. 2011;8(3):198-202. [PubMed: 21448305].
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