Jundishapur Journal of Microbiology

Published by: Kowsar

Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology

Theeraya Simawaranon 1 , Wareeporn Wattanawongdon 1 and Taweesak Tongtawee 2 , *
Authors Information
1 Ph.D Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
2 Assistant Professor, MD., Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
Article information
  • Jundishapur Journal of Microbiology: December 2017, 10 (12); e58351
  • Published Online: November 26, 2017
  • Article Type: Research Article
  • Received: August 11, 2017
  • Revised: October 19, 2017
  • Accepted: October 25, 2017
  • DOI: 10.5812/jjm.58351

To Cite: Simawaranon T, Wattanawongdon W, Tongtawee T. Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology, Jundishapur J Microbiol. 2017 ; 10(12):e58351. doi: 10.5812/jjm.58351.

Abstract
Copyright © 2017, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusions
Acknowledgements
Footnotes
References
  • 1. Castano-Rodriguez N, Kaakoush NO, Mitchell HM. Pattern-recognition receptors and gastric cancer. Front Immunol. 2014; 5: 336[DOI][PubMed]
  • 2. Nomura AM, Lee J, Stemmermann GN, Nomura RY, Perez-Perez GI, Blaser MJ. Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis. 2002; 186(8): 1138-44[DOI][PubMed]
  • 3. Pinto-Santini D, Salama NR. The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2005; 14(8): 1853-8[DOI][PubMed]
  • 4. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001; 345(11): 784-9[DOI][PubMed]
  • 5. Uchida T, Miftahussurur M, Pittayanon R, Vilaichone RK, Wisedopas N, Ratanachu-Ek T, et al. Helicobacter pylori Infection in Thailand: A Nationwide Study of the CagA Phenotype. PLoS One. 2015; 10(9)[DOI][PubMed]
  • 6. Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006; 19(3): 449-90[DOI][PubMed]
  • 7. Atherton JC. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu Rev Pathol. 2006; 1: 63-96[DOI][PubMed]
  • 8. Meining A, Morgner A, Miehlke S, Bayerdorffer E, Stolte M. Atrophy-metaplasia-dysplasia-carcinoma sequence in the stomach: a reality or merely an hypothesis? Best Pract Res Clin Gastroenterol. 2001; 15(6): 983-98[DOI][PubMed]
  • 9. Hawn TR, Misch EA, Dunstan SJ, Thwaites GE, Lan NT, Quy HT, et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol. 2007; 37(8): 2280-9[DOI][PubMed]
  • 10. Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M, et al. Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci. 2007; 98(11): 1790-4[DOI][PubMed]
  • 11. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000; 25(2): 187-91[DOI][PubMed]
  • 12. Schmausser B, Andrulis M, Endrich S, Lee SK, Josenhans C, Muller-Hermelink HK, et al. Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol. 2004; 136(3): 521-6[DOI][PubMed]
  • 13. Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun. 2010; 78(1): 468-76[DOI][PubMed]
  • 14. Cabrera-Andrade A, Lopez-Cortes A, Munoz MJ, Jaramillo-Koupermann G, Rodriguez O, Leone PE, et al. Association of genetic variants of membrane receptors related to recognition and induction of immune response with Helicobacter pylori infection in Ecuadorian individuals. Int J Immunogenet. 2014; 41(4): 281-8[DOI][PubMed]
  • 15. Yang CA, Scheibenbogen C, Bauer S, Kleinle C, Wex T, Bornschein J, et al. A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-gamma production and is associated with Helicobacter pylori-induced gastric disease. Helicobacter. 2013; 18(1): 13-21[DOI][PubMed]
  • 16. Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012; 104(6): 488-92[DOI][PubMed]
  • 17. Wong BC, Zhang L, Ma JL, Pan KF, Li JY, Shen L, et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Gut. 2012; 61(6): 812-8[DOI][PubMed]
  • 18. You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006; 98(14): 974-83[DOI][PubMed]
  • 19. Ravishankar Ram M, Goh KL, Leow AH, Poh BH, Loke MF, Harrison R, et al. Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection. PLoS One. 2015; 10(11)[DOI][PubMed]
  • 20. Tongtawee T, Dechsukhum C, Leeanansaksiri W, Kaewpitoon S, Kaewpitoon N, Loyd RA, et al. Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using "Site Specific Biopsy": a Randomized Control Clinical Trial. Asian Pac J Cancer Prev. 2015; 16(18): 8487-90[PubMed]
  • 21. Tongtawee T, Kaewpitoon S, Kaewpitoon N, Dechsukhum C, Leeanansaksiri W, Loyd RA, et al. Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand. Asian Pac J Cancer Prev. 2016; 17(1): 341-5[PubMed]
  • 22. Tongtawee T, Dechsukhum C, Leeanansaksiri W, Kaewpitoon S, Kaewpitoon N, Loyd RA, et al. Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis. Asian Pac J Cancer Prev. 2015; 16(16): 7049-52[PubMed]
  • 23. Tongtawee T, Dechsukhum C, Talabnin K, Leeanansaksiri W, Kaewpitoon S, Kaewpitoon N, et al. Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated Gastritis in Thailand. Asian Pac J Cancer Prev. 2015; 16(17): 7781-4[PubMed]
  • 24. Mayerle J, den Hoed CM, Schurmann C, Stolk L, Homuth G, Peters MJ, et al. Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA. 2013; 309(18): 1912-20[DOI][PubMed]
  • 25. Tongtawee T, Bartpho T, Kaewpitoon S, Kaewpitoon N, Dechsukhum C, Leeanansaksiri W, et al. Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand. Eur J Cancer Prev. 2017; [DOI][PubMed]
  • 26. Tongtawee T, Bartpho T, Wattanawongdon W, Dechsukhum C, Leeanansaksiri W, Matrakool L, et al. Role of toll-like receptor 10 gene polymorphism and gastric mucosal pattern in patients with chronic gastritis. Turk J Gastroenterol. 2017; 28(4): 243-7[DOI][PubMed]
  • 27. Tang FB, Li ZX, Wang YM, Zhang L, Ma JL, Zhou T, et al. Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population. Infect Genet Evol. 2015; 31: 263-9[DOI][PubMed]
  • 28. Castano-Rodriguez N, Kaakoush NO, Pardo AL, Goh KL, Fock KM, Mitchell HM. Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer. Hum Immunol. 2014; 75(8): 808-15[DOI][PubMed]
  • 29. Castano-Rodriguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM. The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis. PLoS One. 2013; 8(4)[DOI][PubMed]
  • 30. Uno K, Kato K, Atsumi T, Suzuki T, Yoshitake J, Morita H, et al. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007; 293(5)-12[DOI][PubMed]
  • 31. de Oliveira JG, Silva AE. Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. World J Gastroenterol. 2012; 18(11): 1235-42[DOI][PubMed]
  • 32. Pohjanen VM, Koivurova OP, Huhta H, Helminen O, Makinen JM, Karhukorpi JM, et al. Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk. PLoS One. 2015; 10(7)[DOI][PubMed]
  • 33. Loganathan R, Nazeer M, Goda V, Devaraju P, Ali M, Karunakaran P, et al. Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils. Hum Immunol. 2017; 78(2): 216-20[DOI][PubMed]
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