Jundishapur Journal of Microbiology

Published by: Kowsar

In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates

Mohammad Reza Sarrafha 1 , Seyed Jamal Hashemi 2 , * , Sasan Rezaei 2 and Mansour Bayat 1
Authors Information
1 Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, IR Iran
2 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: June 2018, 11 (6); e57875
  • Published Online: May 15, 2018
  • Article Type: Research Article
  • Received: July 9, 2017
  • Revised: April 30, 2018
  • Accepted: May 1, 2018
  • DOI: 10.5812/jjm.57875

To Cite: Sarrafha M R, Hashemi S J, Rezaei S, Bayat M. In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates, Jundishapur J Microbiol. 2018 ; 11(6):e57875. doi: 10.5812/jjm.57875.

Copyright © 2018, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusions
  • 1. Sanz Alonso MA, Jarque Ramos I, Salavert Lletí M, Pemán J. Epidemiology of invasive fungal infections due to Aspergillus spp. and Zygomycetes. Clin Microbiol Infect. 2006;12:2-6. doi: 10.1111/j.1469-0691.2006.01602.x.
  • 2. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(3):327-60. doi: 10.1086/525258. [PubMed: 18177225].
  • 3. Hope WW, Walsh TJ, Denning DW. Laboratory diagnosis of invasive aspergillosis. Lancet Infect Dis. 2005;5(10):609-22. doi: 10.1016/S1473-3099(05)70238-3. [PubMed: 16183515].
  • 4. Seyedmousavi S, Guillot J, Arne P, de Hoog GS, Mouton JW, Melchers WJ, et al. Aspergillus and aspergilloses in wild and domestic animals: a global health concern with parallels to human disease. Med Mycol. 2015;53(8):765-97. doi: 10.1093/mmy/myv067. [PubMed: 26316211].
  • 5. Hedayati MT, Pasqualotto AC, Warn PA, Bowyer P, Denning DW. Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology. 2007;153(Pt 6):1677-92. doi: 10.1099/mic.0.2007/007641-0. [PubMed: 17526826].
  • 6. Leishangthem GD, Singh ND, Brar RS, Banga HS. Aspergillosis in avian species: A review. J Poult Sci Technol. 2015;3(1):1-14.
  • 7. Hagiwara D, Watanabe A, Kamei K. Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene. Sci Rep. 2016;6:38833. doi: 10.1038/srep38833. [PubMed: 27934927]. [PubMed Central: PMC5146965].
  • 8. Vermeulen E, Cooreman S, Maertens J, Jeurissen A, Lagrou K. Azole resistance in Aspergillus: an emerging problem? Acta Clin Belg. 2012;67(5):322-7. doi: 10.2143/ACB.67.5.2062684. [PubMed: 23189538].
  • 9. Mohammadi F, Hashemi SJ, Zoll J, Melchers WJ, Rafati H, Dehghan P, et al. Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014. Antimicrob Agents Chemother. 2016;60(1):387-92. doi: 10.1128/AAC.02326-15. [PubMed: 26525787]. [PubMed Central: PMC4704245].
  • 10. Mellado E, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL. Role of Aspergillus lentulus 14-alpha sterol demethylase (Cyp51A) in azole drug susceptibility. Antimicrob Agents Chemother. 2011;55(12):5459-68. doi: 10.1128/AAC.05178-11. [PubMed: 21947395]. [PubMed Central: PMC3232793].
  • 11. Dua JS, Rana AC, Bhandari AK. Liposome: methods of preparation and applications. Int J Pharm Stud Res. 2012;3(2):14-20.
  • 12. Venkateswarlu I, Jayashankar Reddy V, Ramesh Y, Viswanatha Reddy M, Pravallika CH, Suneetha KC. A Review on Liposomes. RJPBCS. 2011;2(3):739-51.
  • 13. Jenning V, Schafer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release. 2000;66(2-3):115-26. [PubMed: 10742573].
  • 14. El-Nesr OH, Yahiya SA, El-Gazayerly ON. Effect of formulation design and freeze-drying on properties of fluconazole multilamellar liposomes. Saudi Pharm J. 2010;18(4):217-24. doi: 10.1016/j.jsps.2010.07.003. [PubMed: 23960730]. [PubMed Central: PMC3730971].
  • 15. Shinoda T. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Jpn J Med Mycol. 1999;40:243-6.
  • 16. Asadi M, Hashemi JS, Hamishehkar H, Kordbacheh P, Ghasemi Z, Didehdar M, et al. In vitro evaluation of antifungal effects of nanoliposomal fluconazole against fluconazole susceptible and resistant Candida species isolated from patients. Biosci Biotechnol Res Commun. 2016;9(4):633-42.
  • 17. Tang X, Zhu H, Sun L, Hou W, Cai S, Zhang R, et al. Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA) nanoparticles in vitro and in vivo. Int J Nanomedicine. 2014;9:5403-13. doi: 10.2147/IJN.S71623. [PubMed: 25473279]. [PubMed Central: PMC4247144].
  • 18. Zhang Y, Yang M, Portney NG, Cui D, Budak G, Ozbay E, et al. Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells. Biomed Microdevices. 2008;10(2):321-8. doi: 10.1007/s10544-007-9139-2. [PubMed: 18165903].
  • 19. Honary S, Zahir F. Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2). Trop J Pharm Res. 2013;12(2). doi: 10.4314/tjpr.v12i2.20.
  • 20. Fattahi A, Zaini F, Kordbacheh P, Hashemi SJ, Mahmoudi M, Safara M. In vitro susceptibility of aflatoxigenic and non-aflatoxigenic Aspergillus flavus strains to conventional antifungal agents. Acta Med Iran. 2012;50(12):798-804. [PubMed: 23456520].
  • 21. Moore CB, Sayers N, Mosquera J, Slaven J, Denning DW. Antifungal drug resistance in Aspergillus. J Infect. 2000;41(3):203-20. doi: 10.1053/jinf.2000.0747. [PubMed: 11120607].
  • 22. Messer SA, Jones RN, Fritsche TR. International surveillance of Candida spp. and Aspergillus spp.: report from the SENTRY Antimicrobial Surveillance Program (2003). J Clin Microbiol. 2006;44(5):1782-7. doi: 10.1128/JCM.44.5.1782-1787.2006. [PubMed: 16672407]. [PubMed Central: PMC1479200].
  • 23. Sabatelli F, Patel R, Mann PA, Mendrick CA, Norris CC, Hare R, et al. In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob Agents Chemother. 2006;50(6):2009-15. doi: 10.1128/AAC.00163-06. [PubMed: 16723559]. [PubMed Central: PMC1479149].
  • 24. Warrilow AG, Melo N, Martel CM, Parker JE, Nes WD, Kelly SL, et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother. 2010;54(10):4225-34. doi: 10.1128/AAC.00316-10. [PubMed: 20660663]. [PubMed Central: PMC2944604].
  • 25. Vikaas B, Manjusha B, Manjusha C. Nanotechnology: Applications in pharmaceutical drug delivery systems. J Chem Pharm Res. 2016;8(8):259-65.
  • 26. Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001;47(2-3):165-96. [PubMed: 11311991].
  • 27. Bose S, Du Y, Takhistov P, Michniak-Kohn B. Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Int J Pharm. 2013;441(1-2):56-66. doi: 10.1016/j.ijpharm.2012.12.013. [PubMed: 23262430].
  • 28. Gupta M, Tiwari S, Vyas SP. Influence of various lipid core on characteristics of SLNs designed for topical delivery of fluconazole against cutaneous candidiasis. Pharm Dev Technol. 2013;18(3):550-9. doi: 10.3109/10837450.2011.598161. [PubMed: 21810069].
  • 29. Solano-Umana V, Vega-Baudrit JR, González-Paz R. The new field of the nanomedicine. Int J Appl. 2015;5(1).
  • 30. Subbenaik SC. Physical and chemical nature of nanoparticles. Plant nanotechnology. Springer; 2016.

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments