Jundishapur Journal of Microbiology

Published by: Kowsar

Mutational Analysis of Plasmodium vivax dhfr Gene Among Cases in South East of Iran

Hadi Mirahmadi 1 , 2 , Maryam Rafee 2 , Jalal Zaman 3 , Ahmad Mehravaran 1 , 2 and Reza Shafiei 4 , *
Authors Information
1 Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2 Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3 Orumiyeh military Hospital, Health Administration of Army (NEZAJA), Tehran, Iran
4 Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
Article information
  • Jundishapur Journal of Microbiology: September 2017, 10 (9); e57697
  • Published Online: August 30, 2017
  • Article Type: Research Article
  • Received: February 26, 2017
  • Revised: July 26, 2017
  • Accepted: August 6, 2017
  • DOI: 10.5812/jjm.57697

To Cite: Mirahmadi H, Rafee M, Zaman J, Mehravaran A, Shafiei R. Mutational Analysis of Plasmodium vivax dhfr Gene Among Cases in South East of Iran, Jundishapur J Microbiol. 2017 ; 10(9):e57697. doi: 10.5812/jjm.57697.

Abstract
Copyright © 2017, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Mendis K, Sina BJ, Marchesini P, Carter R. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001; 64(1-2 Suppl): 97-106[DOI][PubMed]
  • 2. Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM. Vivax malaria: neglected and not benign. Am J Trop Med Hyg. 2007; 77(6 Suppl): 79-87[DOI][PubMed]
  • 3. Mohammadzadeh T, Hatam G, Kalantari M, Sarkari B, Motazedian MH, Sadjjadi SM, et al. Molecular and microscopic-based characterization of plasmodium spp. in Fars and Hormozgan provinces, south of Iran. J Trop Med. 2014; 2014: 935469[DOI][PubMed]
  • 4. Mirahmadi H, Fallahi S, Seyyed Tabaei SJ. Soluble recombinant merozoite surface antigen-142kDa of Plasmodium vivax: An improved diagnostic antigen for vivax malaria. J Microbiol Methods. 2016; 123: 44-50[DOI][PubMed]
  • 5. Mirahmadi H, Spotin A, Fallahi S, Taghipour N, Turki H, Seyyed Tabaei SJ. Cloning and sequence analysis of recombinant plasmodium vivax merozoite surface protein 1 (PvMSP-142 kDa) in pTZ57R/T vector. Iran J Parasitol. 2015; 10(2): 197-205[PubMed]
  • 6. Mirahmadi H, Fallahi S, Fallah Omrani V, Kazemi B, Haghighi A, Seyyed Tabaei SJ. High-level xpression of immunogenic recombinant plasmodium vivax merozoite surface protein (pvmsp-142 kDa) in pGEX 6P1 vector. Iran J Public Health. 2015; 44(1): 89-99[PubMed]
  • 7. Shafiei R, Mahmoodzadeh A, Hajia M, Sanati A, Shafiei F. Epidemiology of malaria in khorasan razavi province, Northeast of Iran, within 7 years (April 2001 - March 2008). Ann Trop Med Public Health. 2011; 4(1): 12-7[DOI]
  • 8. Zakeri S, Barjesteh H, Djadid ND. Merozoite surface protein-3alpha is a reliable marker for population genetic analysis of Plasmodium vivax. Malar J. 2006; 5: 53[DOI][PubMed]
  • 9. Pukrittayakamee S, Chantra A, Simpson JA, Vanijanonta S, Clemens R, Looareesuwan S, et al. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob Agents Chemother. 2000; 44(6): 1680-5[DOI][PubMed]
  • 10. Ratcliff A, Siswantoro H, Kenangalem E, Wuwung M, Brockman A, Edstein MD, et al. Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia. Trans R Soc Trop Med Hyg. 2007; 101(4): 351-9[DOI][PubMed]
  • 11. Alam MT, Bora H, Bharti PK, Saifi MA, Das MK, Dev V, et al. Similar trends of pyrimethamine resistance-associated mutations in Plasmodium vivax and P. falciparum. Antimicrob Agents Chemother. 2007; 51(3): 857-63[DOI][PubMed]
  • 12. Zaman J, Shahbazi A, Asgharzadeh M. Plasmodium vivax dhfr mutations among isolates from malarious areas of Iran. Korean J Parasitol. 2011; 49(2): 125-31[DOI][PubMed]
  • 13. Baird JK. Resistance to therapies for infection by Plasmodium vivax. Clin Microbiol Rev. 2009; 22(3): 508-34[DOI][PubMed]
  • 14. Kurcer MA, Simsek Z, Zeyrek FY, Atay S, Celik H, Kat I, et al. Efficacy of chloroquine in the treatment of Plasmodium vivax malaria in Turkey. Ann Trop Med Parasitol. 2004; 98(5): 447-51[DOI][PubMed]
  • 15. Soto J, Toledo J, Gutierrez P, Luzz M, Llinas N, Cedeno N, et al. Plasmodium vivax clinically resistant to chloroquine in Colombia. Am J Trop Med Hyg. 2001; 65(2): 90-3[DOI][PubMed]
  • 16. Zakeri S, Motmaen SR, Afsharpad M, Djadid ND. Molecular characterization of antifolates resistance-associated genes, (dhfr and dhps) in Plasmodium vivax isolates from the Middle East. Malar J. 2009; 8: 20[DOI][PubMed]
  • 17. Zakeri S, Najafabadi ST, Zare A, Djadid ND. Detection of malaria parasites by nested PCR in south-eastern, Iran: evidence of highly mixed infections in Chahbahar district. Malar J. 2002; 1: 2[DOI][PubMed]
  • 18. Zakeri S, Gil JP, Bereckzy S, Djadid ND, Bjorkman A. High prevalence of double Plasmodium falciparum dhfr mutations at codons 108 and 59 in the Sistan-Baluchistan province, Iran. J Infect Dis. 2003; 187(11): 1828-9[DOI][PubMed]
  • 19. Sirawaraporn W, Prapunwattana P, Sirawaraporn R, Yuthavong Y, Santi DV. The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants. J Biol Chem. 1993; 268(29): 21637-44[PubMed]
  • 20. Barnadas C, Tichit M, Bouchier C, Ratsimbasoa A, Randrianasolo L, Raherinjafy R, et al. Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine. Malar J. 2008; 7: 35[DOI][PubMed]
  • 21. Hawkins VN, Joshi H, Rungsihirunrat K, Na-Bangchang K, Sibley CH. Antifolates can have a role in the treatment of Plasmodium vivax. Trends Parasitol. 2007; 23(5): 213-22[DOI][PubMed]
  • 22. Sharifi-Sarasiabi K, Haghighi A, Kazemi B, Taghipour N, Mojarad EN, Gachkar L. Molecular surveillance of Plasmodium vivax and Plasmodium falciparum dhfr mutations in isolates from southern Iran Rev Inst Med Trop Sao Paulo. 2016; 58: 16[DOI][PubMed]
  • 23. Nateghpour M, Sayedzadeh SA, Edrissian GH, Raeisi A, Jahantigh A, Motevalli-Haghi A, et al. Evaluation of sensitivity of Plasmodium vivax to chloroquine. Iranian J Publ Health. 2007; 36: 60-3
  • 24. Huang F, Zhou S, Zhang S, Li W, Zhang H. Monitoring resistance of Plasmdium vivax: point mutations in dihydrofolate reductase gene in isolates from Central China. Parasit Vectors. 2011; 4: 80[DOI][PubMed]
  • 25. Zakeri S, Afsharpad M, Ghasemi F, Raeisi A, Safi N, Butt W, et al. Molecular surveillance of Plasmodium vivax dhfr and dhps mutations in isolates from Afghanistan. Malar J. 2010; 9: 75[DOI][PubMed]
  • 26. Khatoon L, Baliraine FN, Bonizzoni M, Malik SA, Yan G. Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan. Am J Trop Med Hyg. 2009; 81(3): 525-8[PubMed]
  • 27. Brega S, de Monbrison F, Severini C, Udomsangpetch R, Sutanto I, Ruckert P, et al. Real-time PCR for dihydrofolate reductase gene single-nucleotide polymorphisms in Plasmodium vivax isolates. Antimicrob Agents Chemother. 2004; 48(7): 2581-7[DOI][PubMed]
  • 28. Hastings MD, Porter KM, Maguire JD, Susanti I, Kania W, Bangs MJ, et al. Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine. J Infect Dis. 2004; 189(4): 744-50[DOI][PubMed]
  • 29. Imwong M, Pukrittakayamee S, Looareesuwan S, Pasvol G, Poirreiz J, White NJ, et al. Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates. Antimicrob Agents Chemother. 2001; 45(11): 3122-7[DOI][PubMed]
  • 30. Na BK, Lee HW, Moon SU, In TS, Lin K, Maung M, et al. Genetic variations of the dihydrofolate reductase gene of Plasmodium vivax in Mandalay Division, Myanmar. Parasitol Res. 2005; 96(5): 321-5[DOI][PubMed]
  • 31. Rungsihirunrat K, Na-Bangchang K, Hawkins VN, Mungthin M, Sibley CH. Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand. Am J Trop Med Hyg. 2007; 76(6): 1057-65[PubMed]
  • 32. Tahar R, de Pecoulas PE, Basco LK, Chiadmi M, Mazabraud A. Kinetic properties of dihydrofolate reductase from wild-type and mutant Plasmodium vivax expressed in Escherichia coli. Mol Biochem Parasitol. 2001; 113(2): 241-9[DOI][PubMed]
  • 33. de Pecoulas PE, Tahar R, Ouatas T, Mazabraud A, Basco LK. Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance. Mol Biochem Parasitol. 1998; 92(2): 265-73[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments