Jundishapur Journal of Microbiology

Published by: Kowsar

Occurrence of a Multidrug Resistant Pseudomonas aeruginosa Strains in Hospitalized Patients in Southwest of Iran: Characterization of Resistance Trends and Virulence Determinants

Shahrbanou Izadi Pour Jahromi 1 , Jalal Mardaneh 2 , Asghar Sharifi 1 , * , Vahid Pezeshkpour 1 , Abbas Behzad-Behbahani 3 , Noorossadat Seyyedi 3 , Gholamreza Rafiei Dehbidi 3 , Leila Manzouri 4 , Masoud Pourmasoudi 3 , Seyed Sajjad Khoramrooz 1 and Seyed Abdolmajid Khosravani 1
Authors Information
1 Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IR Iran
2 Department of Microbiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran
3 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, IR Iran
Article information
  • Jundishapur Journal of Microbiology: April 2018, 11 (4); e57341
  • Published Online: February 23, 2018
  • Article Type: Research Article
  • Received: July 25, 2017
  • Revised: December 8, 2017
  • Accepted: January 9, 2018
  • DOI: 10.5812/jjm.57341

To Cite: Izadi Pour Jahromi S, Mardaneh J, Sharifi A, Pezeshkpour V, Behzad-Behbahani A, et al. Occurrence of a Multidrug Resistant Pseudomonas aeruginosa Strains in Hospitalized Patients in Southwest of Iran: Characterization of Resistance Trends and Virulence Determinants, Jundishapur J Microbiol. 2018 ; 11(4):e57341. doi: 10.5812/jjm.57341.

Copyright © 2018, Jundishapur Journal of Microbiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusions
  • 1. Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22(4):582-610. doi: 10.1128/CMR.00040-09. [PubMed: 19822890].
  • 2. Poorabbas B, Mardaneh J, Rezaei Z, Kalani M, Pouladfar G, Alami MH, et al. Nosocomial Infections: Multicenter surveillance of antimicrobial resistance profile of Staphylococcus aureus and Gram negative rods isolated from blood and other sterile body fluids in Iran. Iran J Microbiol. 2015;7(3):127-35. [PubMed: 26668699].
  • 3. Tiwari N, Rajdev S, Mullan S. Resistance Trends among <i>Pseudomonas aeruginosa</i> Isolates in a Tertiary Care Centre in South Gujarat. Adv Microbiol. 2017;7(3):188-94. doi: 10.4236/aim.2017.73015.
  • 4. Lister PD. Chromosomally-encoded resistance mechanisms of Pseudomonas aeruginosa: therapeutic implications. Am J Pharmacogenomics. 2002;2(4):235-43. [PubMed: 12421094].
  • 5. Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2005;171(11):1209-23. doi: 10.1164/rccm.200408-1044SO. [PubMed: 15695491].
  • 6. Lavoie EG, Wangdi T, Kazmierczak BI. Innate immune responses to Pseudomonas aeruginosa infection. Microbes Infect. 2011;13(14-15):1133-45. doi: 10.1016/j.micinf.2011.07.011. [PubMed: 21839853].
  • 7. Branski LK, Al-Mousawi A, Rivero H, Jeschke MG, Sanford AP, Herndon DN. Emerging infections in burns. Surg Infect. 2009;10(5):389-97. doi: 10.1089/sur.2009.024. [PubMed: 19810827].
  • 8. Rossolini GM, Mantengoli E. Treatment and control of severe infections caused by multiresistant Pseudomonas aeruginosa. Clin Microbiol Infect. 2005;11 Suppl 4:17-32. doi: 10.1111/j.1469-0691.2005.01161.x. [PubMed: 15953020].
  • 9. Anvarinejad M, Japoni A, Rafaatpour N, Mardaneh J, Abbasi P, Amin Shahidi M, et al. Burn Patients wounds Infected With Metallo-Beta-Lactamase-Producing Pseudomonas aeruginosa: Multidrug Resistant Strains. Arch Trauma Res. 2014;3(2). doi: 10.5812/atr.18182.
  • 10. Meletis G, Exindari M, Vavatsi N, Sofianou D, Diza E. Mechanisms responsible for the emergence of carbapenem resistance in Pseudomonas aeruginosa. Hippokratia. 2012;16(4):303-7. [PubMed: 23935307].
  • 11. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015;40(4):277-83. [PubMed: 25859123].
  • 12. Nordmann P, Naas T, Poirel L. Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(10):1791-8. doi: 10.3201/eid1710.110655. [PubMed: 22000347].
  • 13. Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev. 2007;20(3):440-58. table of contents. doi: 10.1128/CMR.00001-07. [PubMed: 17630334].
  • 14. Zmarlicka MT, Nailor MD, Nicolau DP. Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics. Infect Drug Resist. 2015;8:297-309. doi: 10.2147/IDR.S39186. [PubMed: 26345624].
  • 15. Mitov I, Strateva T, Markova B. Prevalence of virulence genes among bulgarian nosocomial and cystic fibrosis isolates of pseudomonas aeruginosa. Braz J Microbiol. 2010;41(3):588-95. doi: 10.1590/S1517-83822010000300008. [PubMed: 24031533].
  • 16. Kipnis E, Sawa T, Wiener-Kronish J. Targeting mechanisms of Pseudomonas aeruginosa pathogenesis. Med Mal Infect. 2006;36(2):78-91. doi: 10.1016/j.medmal.2005.10.007. [PubMed: 16427231].
  • 17. Stehling EG, Silveira WD, Leite Dda S. Study of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infections. Braz J Infect Dis. 2008;12(1):86-8. [PubMed: 18553021].
  • 18. Sonbol FI, Khalil MA, Mohamed AB, Ali SS. Correlation between antibiotic resistance and virulence of Pseudomonas aeruginosa clinical isolates. Turk J Med Sci. 2015;45(3):568-77. [PubMed: 26281322].
  • 19. Fazeli N, Momtaz H. Virulence Gene Profiles of Multidrug-Resistant Pseudomonas aeruginosa Isolated From Iranian Hospital Infections. Iran Red Crescent Med J. 2014;16(10). e15722. doi: 10.5812/ircmj.15722. [PubMed: 25763199].
  • 20. Lee VT, Smith RS, Tummler B, Lory S. Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect Immun. 2005;73(3):1695-705. doi: 10.1128/IAI.73.3.1695-1705.2005. [PubMed: 15731070].
  • 21. Wayne PA. Performance standards for antimicrobial susceptibility testing. 2007.Clinical and laboratory standards institute.
  • 22. Beceiro A, Tomas M, Bou G. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev. 2013;26(2):185-230. doi: 10.1128/CMR.00059-12. [PubMed: 23554414].
  • 23. Mellouk FZ, Bakour S, Meradji S, Al-Bayssari C, Bentakouk MC, Zouyed F, et al. First Detection of VIM-4-Producing Pseudomonas aeruginosa and OXA-48-Producing Klebsiella pneumoniae in Northeastern (Annaba, Skikda) Algeria. Microb Drug Resist. 2017;23(3):335-44. doi: 10.1089/mdr.2016.0032. [PubMed: 27314660].
  • 24. Webber MA, Yayan J, Ghebremedhin B, Rasche K. Antibiotic Resistance of Pseudomonas aeruginosa in Pneumonia at a Single University Hospital Center in Germany over a 10-Year Period. Plos One. 2015;10(10). e0139836. doi: 10.1371/journal.pone.0139836.
  • 25. Malkocoglu G, Aktas E, Bayraktar B, Otlu B, Bulut ME. VIM-1, VIM-2, and GES-5 Carbapenemases Among Pseudomonas aeruginosa Isolates at a Tertiary Hospital in Istanbul, Turkey. Microb Drug Resist. 2017;23(3):328-34. doi: 10.1089/mdr.2016.0012. [PubMed: 27326514].
  • 26. Burgess DS, Nathisuwan S. Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa. Diagnos Microbiol Infect Dis. 2002;44(1):35-41. doi: 10.1016/S0732-8893(02)00420-0.
  • 27. Farajzadeh Sheikh A, Rostami S, Jolodar A, Tabatabaiefar MA, Khorvash F, Saki A, et al. Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa. Jundishapur J Microbiol. 2014;7(8). doi: 10.5812/jjm.12289.
  • 28. Onguru P, Erbay A, Bodur H, Baran G, Akinci E, Balaban N, et al. Imipenem-resistant Pseudomonas aeruginosa: risk factors for nosocomial infections. J Korean Med Sci. 2008;23(6):982-7. doi: 10.3346/jkms.2008.23.6.982. [PubMed: 19119440].
  • 29. Luyt CE, Aubry A, Lu Q, Micaelo M, Brechot N, Brossier F, et al. Imipenem, meropenem, or doripenem to treat patients with Pseudomonas aeruginosa ventilator-associated pneumonia. Antimicrob Agents Chemother. 2014;58(3):1372-80. doi: 10.1128/AAC.02109-13. [PubMed: 24342638].
  • 30. Dong D, Zou D, Liu H, Yang Z, Huang S, Liu N, et al. Rapid detection of Pseudomonas aeruginosa targeting the toxA gene in intensive care unit patients from Beijing, China. Front Microbiol. 2015;6:1100. doi: 10.3389/fmicb.2015.01100. [PubMed: 26500639].
  • 31. Mohammadzadeh A, Mardaneh J, Ahmadi R, Adabi J. Evaluation of the Virulence Features and Antibiotic Resistance Patterns of Pathogenic Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Gonabad, Iran. Arch Pediatr Infect Dis. 2017;In press(In press). doi: 10.5812/pedinfect.41267.
  • 32. Izadpour F, Ranjbari N, Aramesh MR, Moosavian M, ShahAli S, Larki F, et al. An Investigation of Antibacterial Resistance Patterns Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates Collected from Intensive Care Units of a University-Affiliated Hospital in Ahvaz, Iran. Jundishapur J Microbiol. 2016;9(8). doi: 10.5812/jjm.35624.
  • 33. Aghazadeh M, Zahedi Bialvaei A, Aghazadeh M, Kabiri F, Saliani N, Yousefi M, et al. Survey of the Antibiofilm and Antimicrobial Effects of Zingiber officinale (in Vitro Study). Jundishapur J Microbiol. 2016;9(2). e30167. doi: 10.5812/jjm.30167. [PubMed: 27127591].
  • 34. Anvarinejad M, Pouladfar GR, Pourabbas B, Amin Shahidi M, Rafaatpour N, Dehyadegari MA, et al. Detection of Salmonella spp. with the BACTEC 9240 Automated Blood Culture System in 2008 - 2014 in Southern Iran (Shiraz): Biogrouping, MIC, and Antimicrobial Susceptibility Profiles of Isolates. Jundishapur J Microbiol. 2016;9(4). doi: 10.5812/jjm.26505.

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments