Jundishapur Journal of Microbiology

Published by: Kowsar

The Usefulness of Anti-HCV Signal to Cut-off Ratio in Predicting Viremia in Anti-HCV in Patients With Hepatitis C Virus Infection

Fahimeh Ranjbar Kermani 1 , Zohreh Sharifi 1 , * , Fereshteh Ferdowsian 1 , Zahrah Paz 1 and Farzaneh Tavassoli 1
Authors Information
1 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: April 01, 2015, 8 (4); e17841
  • Published Online: April 18, 2015
  • Article Type: Research Article
  • Received: January 26, 2014
  • Revised: July 5, 2014
  • Accepted: July 26, 2014
  • DOI: 10.5812/jjm.8(4)2015.17841

To Cite: Ranjbar Kermani F, Sharifi Z, Ferdowsian F, Paz Z, Tavassoli F. The Usefulness of Anti-HCV Signal to Cut-off Ratio in Predicting Viremia in Anti-HCV in Patients With Hepatitis C Virus Infection, Jundishapur J Microbiol. 2015 ; 8(4):e17841. doi: 10.5812/jjm.8(4)2015.17841.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Majid AM, Gretch DR. Current and future hepatitis C virus diagnostic testing: problems and advancements. Microbes Infect. 2002; 4(12): 1227-36[PubMed]
  • 2. Ghany MG, Strader DB, Thomas DL, Seeff LB, American Association for the Study of Liver D. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009; 49(4): 1335-74[DOI][PubMed]
  • 3. Richter SS. Laboratory assays for diagnosis and management of hepatitis C virus infection. J Clin Microbiol. 2002; 40(12): 4407-12[PubMed]
  • 4. Bossi V, Galli C. Quantitative signal of anti-HCV by an automated assay predicts viremia in a population at high prevalence of hepatitis C virus infection. J Clin Virol. 2004; 30(1): 45-9[DOI][PubMed]
  • 5. Galel SA, Strong DM, Tegtmeier GE, Holland PV, Kuramoto IK, Kemper M, et al. Comparative yield of HCV RNA testing in blood donors screened by 2.0 versus 3.0 antibody assays. Transfusion. 2002; 42(11): 1507-13[PubMed]
  • 6. Balk M, Saydam G, Cengiz D, Tuerkmen A, Simsek H, Himmetoglu T. The utility of ANTI-HCV S/CO ratio, HCV-RNA and ALT test in predicting viremia in ANTI-HCV positive patients. Turk J Biochem. 2007; 32(2): 51-4
  • 7. Sugitani M, Inchauspe G, Shindo M, Prince AM. Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet. 1992; 339(8800): 1018-9[PubMed]
  • 8. Strader DB, Seeff LB. Hepatitis C: a brief clinical overview. ILAR J. 2001; 42(2): 107-16[PubMed]
  • 9. Schiff ER, de Medina M, Kahn RS. New perspectives in the diagnosis of hepatitis C. Semin Liver Dis. 1999; 19 Suppl 1: 3-15[PubMed]
  • 10. Sookoian S, Castano G. Evaluation of a third generation anti-HCV assay in predicting viremia in patients with positive HCV antibodies. Ann Hepatol. 2002; 1(4): 179-82[PubMed]
  • 11. Yuki N, Hayashi N, Hagiwara H, Naito M, Ohkawa K, Kasahara A, et al. Hepatitis C virus antibodies and virus replication in asymptomatic blood donors. Vox Sang. 1994; 67(3): 280-5[PubMed]
  • 12. Dufour DR. Lot-to-lot variation in anti-hepatitis C signal-to-cutoff ratio. Clin Chem. 2004; 50(5): 958-60[DOI][PubMed]
  • 13. Dufour DR, Talastas M, Fernandez MD, Harris B, Strader DB, Seeff LB. Low-positive anti-hepatitis C virus enzyme immunoassay results: an important predictor of low likelihood of hepatitis C infection. Clin Chem. 2003; 49(3): 479-86[PubMed]
  • 14. Lee PL, Wang JH, Tung HD, Lee CM, Lu SN. A higher than expected recovery rate from hepatitis C infection amongst adolescents: a community study in a hepatitis C-endemic township in Taiwan. Trans R Soc Trop Med Hyg. 2004; 98(6): 367-72[DOI][PubMed]
  • 15. Alter MJ, Kuhnert WL, Finelli L, Centers for Disease C. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention. MMWR Recomm Rep. 2003; 52: 1-13[PubMed]
  • 16. Seo YS, Jung ES, Kim JH, Jung YK, Kim JH, An H, et al. Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia. Korean J Intern Med. 2009; 24(4): 302-8[DOI][PubMed]
  • 17. Kim HS. Anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia. Korean J Intern Med. 2009; 24(4): 299-301[DOI][PubMed]
  • 18. Abdelaziz H. HCV signal to cutoff ratio in predicting Hepatitis C viremia. J Blood Disord Transfus. 2013; 4(5): 23-5
  • 19. Lai KK, Jin M, Yuan S, Larson MF, Dominitz JA, Bankson DD. Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay. Clin Chem. 2011; 57(7): 1050-6[DOI][PubMed]
  • 20. Altuğlu İ, Gürsel D, Aksoy A, Orman M, Erensoy S. The importance and role of anti-HCV signal/cutoff ratio in diagnosis of hepatitis C virus infection. Ege J Med. 2011; 50: 223-8
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