Jundishapur Journal of Microbiology

Published by: Kowsar

Detection of Antiseptic Resistance Genes among Staphylococcus aureus Colonising Nurses and Coagulase-Negative Staphylococci Isolated from Clinical Specimens at Teaching Hospitals in Southwest of Iran

Mohammad Sadegh Damavandi 1 , Maryam Safarpour Dehkordi 2 , Alireza Dehghan 3 , Fatemeh Heibati 3 , Roohollah Taghaddosi 1 and Abolfazl Gholipour 1 , *
Authors Information
1 Department of Microbiology and Immunology, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IR Iran
2 Young Researchers and Elite Club, Islamic Azad university, Shahrekord Branch, Shahrekord, Iran
3 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IR Iran
Article information
  • Jundishapur Journal of Microbiology: January 01, 2017, 10 (1); e39285
  • Published Online: December 12, 2016
  • Article Type: Research Article
  • Received: May 28, 2016
  • Revised: October 17, 2016
  • Accepted: December 5, 2016
  • DOI: 10.5812/jjm.39285

To Cite: Damavandi M S, Safarpour Dehkordi M, Dehghan A, Heibati F, Taghaddosi R, et al. Detection of Antiseptic Resistance Genes among Staphylococcus aureus Colonising Nurses and Coagulase-Negative Staphylococci Isolated from Clinical Specimens at Teaching Hospitals in Southwest of Iran, Jundishapur J Microbiol. 2017 ; 10(1):e39285. doi: 10.5812/jjm.39285.

Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Mirani ZA, Aziz M, Khan MN, Lal I, Hassan NU, Khan SI. Biofilm formation and dispersal of Staphylococcus aureus under the influence of oxacillin. Microb Pathog. 2013; 61-62: 66-72[DOI][PubMed]
  • 2. Liu CL, Chen ZJ, Wang F, Hou HY, Wang Y, Zhu XH, et al. The impact of mgrA on progression of Staphylococcus aureus sepsis. Microb Pathog. 2014; 71-72: 56-61[DOI][PubMed]
  • 3. Abraham NM, Jefferson KK. A low molecular weight component of serum inhibits biofilm formation in Staphylococcus aureus. Microb Pathog. 2010; 49(6): 388-91[DOI][PubMed]
  • 4. Ikonomidis A, Vasdeki A, Kristo I, Maniatis AN, Tsakris A, Malizos KN, et al. Association of biofilm formation and methicillin-resistance with accessory gene regulator (agr) loci in Greek Staphylococcus aureus clones. Microb Pathog. 2009; 47(6): 341-4[DOI][PubMed]
  • 5. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010; 23(3): 616-87[DOI][PubMed]
  • 6. Costa SS, Viveiros M, Amaral L, Couto I. Multidrug Efflux Pumps in Staphylococcus aureus: an Update. Open Microbiol J. 2013; 7: 59-71[DOI][PubMed]
  • 7. Carbon C. MRSA and MRSE: is there an answer? Clin Microbiol Infect. 2000; 6 Suppl 2: 17-22[PubMed]
  • 8. Gerba CP. Quaternary ammonium biocides: efficacy in application. Appl Environ Microbiol. 2015; 81(2): 464-9[DOI][PubMed]
  • 9. Deress T, Girma M, Birhan W, Biadgo B, Alemu A. Isolation of Bacteria from Commonly Used Antiseptic and Disinfectant Solutions in Gondar University Hospital. North West Ethiopia. Am J Nurs Res. 2014; 2(3): 44-9[DOI]
  • 10. Tacconelli E, Pop-Vicas AE, D'Agata EM. Increased mortality among elderly patients with meticillin-resistant Staphylococcus aureus bacteraemia. J Hosp Infect. 2006; 64(3): 251-6[DOI][PubMed]
  • 11. Anthonisen IL, Sunde M, Steinum TM, Sidhu MS, Sorum H. Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug- resistant Staphylococcus haemolyticus strains of animal and human origins. Antimicrob Agents Chemother. 2002; 46(11): 3606-12[PubMed]
  • 12. Horner C, Mawer D, Wilcox M. Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter? J Antimicrob Chemother. 2012; 67(11): 2547-59[DOI][PubMed]
  • 13. Furi L, Ciusa ML, Knight D, Di Lorenzo V, Tocci N, Cirasola D, et al. Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus. Antimicrob Agents Chemother. 2013; 57(8): 3488-97[DOI][PubMed]
  • 14. Ortega Morente E, Fernandez-Fuentes MA, Grande Burgos MJ, Abriouel H, Perez Pulido R, Galvez A. Biocide tolerance in bacteria. Int J Food Microbiol. 2013; 162(1): 13-25[DOI][PubMed]
  • 15. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational Supplement. CLSI document M100-S25. 2015;
  • 16. Sidhu MS, Heir E, Leegaard T, Wiger K, Holck A. Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci. Antimicrob Agents Chemother. 2002; 46(9): 2797-803[PubMed]
  • 17. Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, et al. Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. J Med Microbiol. 2005; 54: 557-65[DOI][PubMed]
  • 18. Papa R, Artini M, Cellini A, Tilotta M, Galano E, Pucci P, et al. A new anti-infective strategy to reduce the spreading of antibiotic resistance by the action on adhesion-mediated virulence factors in Staphylococcus aureus. Microb Pathog. 2013; 63: 44-53[DOI][PubMed]
  • 19. Lee YL, Cesario T, Tran C, Stone G, Thrupp L. Nasal colonization by methicillin-resistant coagulase-negative staphylococcus in community skilled nursing facility patients. Am J Infect Control. 2000; 28(3): 269-72[DOI][PubMed]
  • 20. Smith K, Gemmell CG, Hunter IS. The association between biocide tolerance and the presence or absence of qac genes among hospital-acquired and community-acquired MRSA isolates. J Antimicrob Chemother. 2008; 61(1): 78-84[DOI][PubMed]
  • 21. Longtin J, Seah C, Siebert K, McGeer A, Simor A, Longtin Y, et al. Distribution of antiseptic resistance genes qacA, qacB, and smr in methicillin-resistant Staphylococcus aureus isolated in Toronto, Canada, from 2005 to 2009. Antimicrob Agents Chemother. 2011; 55(6): 2999-3001[DOI][PubMed]
  • 22. Edgeworth JD. Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care. J Antimicrob Chemother. 2011; 66: 41-7[DOI][PubMed]
  • 23. Eveillard M, Martin Y, Hidri N, Boussougant Y, Joly-Guillou ML. Carriage of methicillin-resistant Staphylococcus aureus among hospital employees: prevalence, duration, and transmission to households. Infect Control Hosp Epidemiol. 2004; 25(2): 114-20[DOI][PubMed]
  • 24. Walsh SE, Maillard JY, Russell AD, Catrenich CE, Charbonneau DL, Bartolo RG. Development of bacterial resistance to several biocides and effects on antibiotic susceptibility. J Hosp Infect. 2003; 55(2): 98-107[PubMed]
  • 25. Hanssen AM, Ericson Sollid JU. SCCmec in staphylococci: genes on the move. FEMS Immunol Med Microbiol. 2006; 46(1): 8-20[DOI][PubMed]
  • 26. Noguchi N, Nakaminami H, Nishijima S, Kurokawa I, So H, Sasatsu M. Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome. J Clin Microbiol. 2006; 44(6): 2119-25[DOI][PubMed]
  • 27. Miyazaki NH, Abreu AO, Marin VA, Rezende CA, Moraes MT, Villas Boas MH. The presence of qacA/B gene in Brazilian methicillin-resistant Staphylococcus aureus. Mem Inst Oswaldo Cruz. 2007; 102(4): 539-40[PubMed]
  • 28. Lee AS, Macedo-Vinas M, Francois P, Renzi G, Schrenzel J, Vernaz N, et al. Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study. Clin Infect Dis. 2011; 52(12): 1422-30[DOI][PubMed]
  • 29. Hasanvand A, Ghafourian S, Taherikalani M, Jalilian FA, Sadeghifard N, Pakzad I. Antiseptic Resistance in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus Isolates from Some Major Hospitals, Iran. Recent Pat Antiinfect Drug Discov. 2015; 10(2): 105-12[PubMed]
  • 30. Taghaddosi R, Gholipour A, Zeraatpisheh M, Safarpour-Dehkordi M, Darban-Sarokhalil D, Heibati-Goujani F. A frequency and Molecular Typing Study of Methicillin-Resistant Staphylococcus aureus Isolates in Teaching Hospitals in Shahrekord, SouthWestern Iran. Jundishapur J Microbiol. 2016; [DOI]
  • 31. Sidhu MS, Heir E, Sorum H, Holck A. Genetic linkage between resistance to quaternary ammonium compounds and beta-lactam antibiotics in food-related Staphylococcus spp. Microb Drug Resist. 2001; 7(4): 363-71[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments