Jundishapur Journal of Microbiology

Published by: Kowsar

Phenotypic and Genotypic Study of Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus in Tabriz, Northwest Iran

Mojtaba Nikbakht 1 , 2 , 3 , Mohammad Ahangarzadeh Rezaee 1 , 2 , * , Alka Hasani 4 , Mohammad Reza Nahaei 2 , Javid Sadeghi 2 and Sirus Jedari Seifi 2
Authors Information
1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Jundishapur Journal of Microbiology: January 01, 2017, 10 (1); e39274
  • Published Online: December 27, 2016
  • Article Type: Research Article
  • Received: May 19, 2016
  • Revised: December 13, 2016
  • Accepted: December 14, 2016
  • DOI: 10.5812/jjm.39274

To Cite: Nikbakht M, Ahangarzadeh Rezaee M, Hasani A, Nahaei M R, Sadeghi J, et al. Phenotypic and Genotypic Study of Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus in Tabriz, Northwest Iran, Jundishapur J Microbiol. 2017 ; 10(1):e39274. doi: 10.5812/jjm.39274.

Abstract
Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Bhat JA, Tenguria R. Significance of MRSA in nosocomial Infections. Int J Appl Sci Res Rev. 2014; 1(1): 27-36
  • 2. Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest. 2003; 111(9): 1265-73[DOI][PubMed]
  • 3. Nikbakht M, Nahaei MR, Akhi MT, Asgharzadeh M, Nikvash S. Molecular fingerprinting of meticillin-resistant Staphylococcus aureus strains isolated from patients and staff of two Iranian hospitals. J Hosp Infect. 2008; 69(1): 46-55[DOI][PubMed]
  • 4. Cetin ES, Gunes H, Kaya S, Aridogan BC, Demirci M. Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. Int J Antimicrob Agents. 2008; 31(4): 364-8[DOI][PubMed]
  • 5. Leclercq R. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. Clin Infect Dis. 2002; 34(4): 482-92[DOI][PubMed]
  • 6. Levin TP, Suh B, Axelrod P, Truant AL, Fekete T. Potential clindamycin resistance in clindamycin-susceptible, erythromycin-resistant Staphylococcus aureus: report of a clinical failure. Antimicrob Agents Chemother. 2005; 49(3): 1222-4[DOI][PubMed]
  • 7. Kasten MJ. Clindamycin, metronidazole, and chloramphenicol. Mayo Clin Proc. 1999; 74(8): 825-33[DOI][PubMed]
  • 8. Siberry GK, Tekle T, Carroll K, Dick J. Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. Clin Infect Dis. 2003; 37(9): 1257-60[DOI][PubMed]
  • 9. Steward CD, Raney PM, Morrell AK, Williams PP, McDougal LK, Jevitt L, et al. Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus. J Clin Microbiol. 2005; 43(4): 1716-21[DOI][PubMed]
  • 10. Shoja S, Nahaei MR, Nahaei M. Detection of inducible clidamycin resistance in Staphylococcus aureus and Staphylococcus epidermidis by using D-Test. Pharmacol Sci. 2009; 15(11): 1-8
  • 11. Fiebelkorn KR, Crawford SA, McElmeel ML, Jorgensen JH. Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci. J Clin Microbiol. 2003; 41(10): 4740-4[PubMed]
  • 12. O'Sullivan MV, Cai Y, Kong F, Zeng X, Gilbert GL. Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp. J Clin Microbiol. 2006; 44(11): 4072-6[DOI][PubMed]
  • 13. Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P. Gram-Positive Cocci Part I. Koneman's Color Atlas and Textbook of Diagnostic microbiology. 2006; : 623-71
  • 14. Brakstad OG, Aasbakk K, Maeland JA. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol. 1992; 30(7): 1654-60[PubMed]
  • 15. Performance Standard for Antimicrobial Susceptibility Testing. 2014;
  • 16. Aktas Z, Aridogan A, Kayacan CB, Aydin D. Resistance to macrolide, lincosamide and streptogramin antibiotics in staphylococci isolated in Istanbul, Turkey. J Microbiol. 2007; 45(4): 286-90[PubMed]
  • 17. Moosavian M, Shoja S, Rostami S, Torabipour M, Farshadzadeh Z. Inducible clindamycin resistance in clinical isolates of Staphylococcus aureus due to erm genes, Iran. Iran J Microbiol. 2014; 6(6): 421-7[PubMed]
  • 18. Leclercq R, Courvalin P. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. Antimicrob Agents Chemother. 1991; 35(7): 1267-72[PubMed]
  • 19. Mohajeri P, Izadi B, Rezaie M, Falahi B. Prevalence and characteristics of erythromycin and clindamycin resistance in nasal carriers of Staphylococcus aureus of hospital origin, Kermanshah, 2009. J Birjand Univ Med Sci. 2011; 18(1): 32-9
  • 20. Rahbar M, Hajia M. Inducible clindamycin resistance in Staphylococcus aureus: a cross-sectional report. Pak J Biol Sci. 2007; 10(1): 189-92[PubMed]
  • 21. Seifi N, Kahani N, Askari E, Mahdipour S, Naderi NM. Inducible clindamycin resistance in Staphylococcus aureus isolates recovered from Mashhad, Iran. Iran J Microbiol. 2012; 4(2): 82-6[PubMed]
  • 22. Sasirekha B, Usha MS, Amruta JA, Ankit S, Brinda N, Divya R. Incidence of constitutive and inducible clindamycin resistance among hospital-associated Staphylococcus aureus. Biotech. 2014; 4(1): 85-9
  • 23. Nafisi M, Shariati L, Validi M, Karimi A. Prevalence of constitutive and inducible resistance to clindamycin in staphylococci isolates from Hajar and Kashani hospitals in Shahrekord 2008. J Shahrekord Univ Med Sci. 2010; 12(1): 13-20
  • 24. Saderi H, Owlia P, Eslami M. Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) resistance in S. aureus isolated from patients in Tehran, Iran. Iran J Pathol. 2009; 4(4): 161-6
  • 25. Mansouri S, Sadeghi J. Inducible Clindamycin Resistance in Methicillin-Resistant and-Susceptible Staphylococcus aureus Isolated From South East of Iran. Jundishapur J Microbiol. 2014; 7(12)[DOI][PubMed]
  • 26. MH S, MM SD. The importance of inducible clindamycin resistance in enterotoxin positive S. aureus isolated from clinical samples. Tehran Univ Med J TUMS Publicat. 2009; 67(4): 250-6
  • 27. Lall M, Sahni AK. Prevalence of inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples. Med J Armed Forces India. 2014; 70(1): 43-7[DOI][PubMed]
  • 28. Gupta V, Lyall KDS, Chhina D. Inducible clindamycin resistance among clinical isolates of Staphylococcus aureus. J Mahatma Gandhi Inst Med Sci. 2013; 18(2): 112[DOI]
  • 29. Eksi F, Gayyurhan ED, Bayram A, Karsligil T. Determination of antimicrobial susceptibility patterns and inducible clindamycin resistance in Staphylococcus aureus strains recovered from southeastern Turkey. J Microbiol Immunol Infect. 2011; 44(1): 57-62[DOI][PubMed]
  • 30. Velvizhi G, Sucilathangam G, Palaniappan N. Prevalence and phenotypic detection of erythromycin-induced resistance to clindamycin in MRSA isolates. J Clin Diagn Res. 2011; 5(6): 1195-8
  • 31. Saadat S, Solhjoo K, Kazemi A, Mardaneh J. Identification of inducible clindamycin resistance in Staphylococcus areus methicillin resistance from clinical isolates by d-zone test. J Jahrom Univ Med Sci. 2014; 11(4): 18
  • 32. Vidhya R, Parimala S, Beena PM. Inducible clindamycin resistance in Staphylococcus aureus isolates from a rural tertiary care hospital, Kolar. J Clin Biomed Sci. 2013; 3(3): 125-8
  • 33. Saderi H, Emadi B, Owlia P. Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran. Med Sci Monit. 2011; 17(2)-53[PubMed]
  • 34. Schmitz FJ, Sadurski R, Kray A, Boos M, Geisel R, Kohrer K, et al. Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals. J Antimicrob Chemother. 2000; 45(6): 891-4[PubMed]
  • 35. Westh H, Hougaard DM, Vuust J, Rosdahl VT. Prevalence of erm gene classes in erythromycin-resistant Staphylococcus aureus strains isolated between 1959 and 1988. Antimicrob Agents Chemother. 1995; 39(2): 369-73[PubMed]
  • 36. Westh H, Hougaard DM, Vuust J, Rosdahl VT. erm genes in erythromycin-resistant Staphylococcus aureus and coagulase-negative staphylococci. APMIS. 1995; 103(3): 225-32[PubMed]
  • 37. Spiliopoulou I, Petinaki E, Papandreou P, Dimitracopoulos G. erm(C) is the predominant genetic determinant for the expression of resistance to macrolides among methicillin-resistant Staphylococcus aureus clinical isolates in Greece. J Antimicrob Chemother. 2004; 53(5): 814-7[DOI][PubMed]
  • 38. Cetin ES, Gunes H, Kaya S, Aridogan BC, Demirci M. Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among clinical staphylococcal isolates in a Turkish university hospital. J Microbiol Immunol Infect. 2010; 43(6): 524-9[DOI][PubMed]
  • 39. Coutinho Vde L, Paiva RM, Reiter KC, de-Paris F, Barth AL, Machado AB. Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates. Braz J Infect Dis. 2010; 14(6): 564-8[PubMed]
  • 40. Lina G, Quaglia A, Reverdy ME, Leclercq R, Vandenesch F, Etienne J. Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci. Antimicrob Agents Chemother. 1999; 43(5): 1062-6[PubMed]
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