Jundishapur Journal of Microbiology

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Resistance of Candida albicans Biofilms to Drugs and the Host Immune System

Doblin Sandai 1 , * , Yasser M Tabana 1 , Ahmad El Ouweini 2 and Ishola Oluwaseun Ayodeji 1
Authors Information
1 Infectomics Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Malaysia
2 School of Pharmacy, Lebanese American University, Byblos, Lebanon
Article information
  • Jundishapur Journal of Microbiology: November 01, 2016, 9 (11); e37385
  • Published Online: September 26, 2016
  • Article Type: Review Article
  • Received: February 24, 2016
  • Revised: September 14, 2016
  • Accepted: September 14, 2016
  • DOI: 10.5812/jjm.37385

To Cite: Sandai D, Tabana Y M, Ouweini A E, Ayodeji I O. Resistance of Candida albicans Biofilms to Drugs and the Host Immune System, Jundishapur J Microbiol. 2016 ; 9(11):e37385. doi: 10.5812/jjm.37385.

Abstract
Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Search Strategy
4. Biofilm Development
5. Biofilm Complex Architecture
6. Metabolic Activity
7. Metabolic Plasticity
8. Results
9. Conclusion
Acknowledgements
Footnotes
References
  • 1. Brown AJ, Odds FC, Gow NA. Infection-related gene expression in Candida albicans. Curr Opin Microbiol. 2007; 10(4): 307-13[DOI][PubMed]
  • 2. Fidel PJ, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999; 12(1): 80-96[PubMed]
  • 3. Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, et al. Guidelines for treatment of candidiasis. Clin Infect Dis. 2004; 38(2): 161-89[DOI][PubMed]
  • 4. Mohammadi P, Shoaie N, Mohammadi S. Isolation and detection of yeast biofilms from urine catheters of infectious patients. Jundishapur J Microbiol. 2012; 5(4): 533-6[DOI]
  • 5. Ramage G, Saville SP, Thomas DP, Lopez-Ribot JL. Candida biofilms: an update. Eukaryot Cell. 2005; 4(4): 633-8[DOI][PubMed]
  • 6. Sardi JC, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJ. Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol. 2013; 62: 10-24[DOI][PubMed]
  • 7. Moran C, Grussemeyer CA, Spalding JR, Benjamin DJ, Reed SD. Candida albicans and non-albicans bloodstream infections in adult and pediatric patients: comparison of mortality and costs. Pediatr Infect Dis J. 2009; 28(5): 433-5[DOI][PubMed]
  • 8. Falagas ME, Apostolou KE, Pappas VD. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies. Eur J Clin Microbiol Infect Dis. 2006; 25(7): 419-25[DOI][PubMed]
  • 9. Taff HT, Nett JE, Zarnowski R, Ross KM, Sanchez H, Cain MT, et al. A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance. PLoS Pathog. 2012; 8(8): 1002848[DOI][PubMed]
  • 10. Ghannoum MA, Rice LB. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 1999; 12(4): 501-17[PubMed]
  • 11. Ishola O, Ting S, Tabana YM, Ahmed M, Yunus M, Mohamed R, et al. The role of isocitrate lyase (ICL1) in the metabolic adaptation of candida albicans biofilms. Jundishapur J Microbiol. 2016; [DOI]
  • 12. Baillie GS, Douglas LJ. Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents. J Antimicrob Chemother. 2000; 46(3): 397-403[PubMed]
  • 13. Chandra J, Mukherjee PK, Leidich SD, Faddoul FF, Hoyer LL, Douglas LJ, et al. Antifungal resistance of candidal biofilms formed on denture acrylic in vitro. J Dent Res. 2001; 80(3): 903-8[PubMed]
  • 14. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clinical Microbiol Rev. 2002; 15(2): 167-93[PubMed]
  • 15. Chandra J, Mukherjee PK, Ghannoum MA. In vitro growth and analysis of Candida biofilms. Nat Protoc. 2008; 3(12): 1909-24[DOI][PubMed]
  • 16. Hawser SP, Douglas LJ. Biofilm formation by Candida species on the surface of catheter materials in vitro. Infect Immun. 1994; 62(3): 915-21[PubMed]
  • 17. Pierce CG, Uppuluri P, Tristan AR, Wormley FJ, Mowat E, Ramage G, et al. A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc. 2008; 3(9): 1494-500[DOI][PubMed]
  • 18. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol. 1995; 49: 711-45[DOI][PubMed]
  • 19. Kuhn DM, George T, Chandra J, Mukherjee PK, Ghannoum MA. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins. Antimicrob Agents Chemother. 2002; 46(6): 1773-80[PubMed]
  • 20. Zarei Mahmoudabadi A, Zarrin M, Kiasat N. Biofilm formation and susceptibility to amphotericin B and fluconazole in Candida albicans. Jundishapur J Microbiol. 2014; 7(7)[DOI]
  • 21. Gristina AG, Shibata Y, Giridhar G, Kreger A, Myrvik QN. The glycocalyx, biofilm, microbes, and resistant infection. Semin Arthroplasty. 1994; 5(4): 160-70[PubMed]
  • 22. Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence. 2013; 4(2): 119-28[DOI][PubMed]
  • 23. Nett JE, Lepak AJ, Marchillo K, Andes DR. Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis. 2009; 200(2): 307-13[DOI][PubMed]
  • 24. Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol. 2001; 183(18): 5385-94[PubMed]
  • 25. Vila T, Rozental S. Biofilm formation as a pathogenicity factor of medically important fungi. 2016;
  • 26. Al-Fattani MA, Douglas LJ. Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol. 2006; 55: 999-1008[DOI][PubMed]
  • 27. Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev. 2004; 17(2): 255-67[PubMed]
  • 28. Nett JE, Sanchez H, Cain MT, Ross KM, Andes DR. Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot Cell. 2011; 10(12): 1660-9[DOI][PubMed]
  • 29. Finkel JS, Mitchell AP. Genetic control of Candida albicans biofilm development. Nat Rev Microbiol. 2011; 9(2): 109-18[DOI][PubMed]
  • 30. Nett J, Lincoln L, Marchillo K, Massey R, Holoyda K, Hoff B, et al. Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. Antimicrob Agents Chemother. 2007; 51(2): 510-20[DOI][PubMed]
  • 31. Watamoto T, Samaranayake LP, Egusa H, Yatani H, Seneviratne CJ. Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals. J Med Microbiol. 2011; 60: 1241-7[DOI][PubMed]
  • 32. Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun. 2003; 71(8): 4333-40[PubMed]
  • 33. Ramage G, Bachmann S, Patterson TF, Wickes BL, Lopez-Ribot JL. Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms. J Antimicrob Chemother. 2002; 49(6): 973-80[PubMed]
  • 34. Bruzual I, Riggle P, Hadley S, Kumamoto CA. Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole. J Antimicrob Chemother. 2007; 59(3): 441-50[DOI][PubMed]
  • 35. Nett JE, Sanchez H, Cain MT, Andes DR. Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. J Infect Dis. 2010; 202(1): 171-5[DOI][PubMed]
  • 36. Brock M. Fungal metabolism in host niches. Curr Opin Microbiol. 2009; 12(4): 371-6[DOI][PubMed]
  • 37. Lorenz MC, Bender JA, Fink GR. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell. 2004; 3(5): 1076-87[DOI][PubMed]
  • 38. Brown AJP. Integration of metabolism with virulence in Candida albicans. 2006;
  • 39. Ene IV, Adya AK, Wehmeier S, Brand AC, MacCallum DM, Gow NA, et al. Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cell Microbiol. 2012; 14(9): 1319-35[DOI][PubMed]
  • 40. Barelle CJ, Priest CL, Maccallum DM, Gow NA, Odds FC, Brown AJ. Niche-specific regulation of central metabolic pathways in a fungal pathogen. Cell Microbiol. 2006; 8(6): 961-71[DOI][PubMed]
  • 41. Fradin C, De Groot P, MacCallum D, Schaller M, Klis F, Odds FC, et al. Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol. 2005; 56(2): 397-415[DOI][PubMed]
  • 42. Garcia-Sanchez S, Mavor AL, Russell CL, Argimon S, Dennison P, Enjalbert B, et al. Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans. Mol Biol Cell. 2005; 16(6): 2913-25[DOI][PubMed]
  • 43. Rubin-Bejerano I, Fraser I, Grisafi P, Fink GR. Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans. Proc Natl Acad Sci U S A. 2003; 100(19): 11007-12[DOI][PubMed]
  • 44. Dickinson JR, Dawes IW, Boyd AS, Baxter RL. 13C NMR studies of acetate metabolism during sporulation of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1983; 80(19): 5847-51[PubMed]
  • 45. Lorenz MC, Fink GR. Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot Cell. 2002; 1(5): 657-62[PubMed]
  • 46. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, et al. The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004; 101(19): 7329-34[DOI][PubMed]
  • 47. Odds FC. Candida and candidosis: a review and bibliography: Bailliere Tindall. 1988;
  • 48. Piskur J, Rozpedowska E, Polakova S, Merico A, Compagno C. How did Saccharomyces evolve to become a good brewer? Trends Genet. 2006; 22(4): 183-6[DOI][PubMed]
  • 49. Niimi M, Kamiyama A, Tokunaga M. Respiration of medically important Candida species and Saccharomyces cerevisiae in relation to glucose effect. J Med Vet Mycol. 1988; 26(3): 195-8[PubMed]
  • 50. Yin Z, Wilson S, Hauser NC, Tournu H, Hoheisel JD, Brown AJ. Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs. Mol Microbiol. 2003; 48(3): 713-24[PubMed]
  • 51. Rodaki A, Bohovych IM, Enjalbert B, Young T, Odds FC, Gow NA, et al. Glucose promotes stress resistance in the fungal pathogen Candida albicans. Mol Biol Cell. 2009; 20(22): 4845-55[DOI][PubMed]
  • 52. Han TL, Cannon RD, Villas-Boas SG. The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet Biol. 2011; 48(8): 747-63[DOI][PubMed]
  • 53. Ramirez MA, Lorenz MC. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes. Eukaryot Cell. 2007; 6(2): 280-90[DOI][PubMed]
  • 54. Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, et al. The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans. MBio. 2012; 3(6)[DOI][PubMed]
  • 55. Brown AJ, Brown GD, Netea MG, Gow NA. Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels. Trends Microbiol. 2014; 22(11): 614-22[DOI][PubMed]
  • 56. Nett J, Andes D. Candida albicans biofilm development, modeling a host-pathogen interaction. Curr Opin Microbiol. 2006; 9(4): 340-5[DOI][PubMed]
  • 57. Silva S, Henriques M, Martins A, Oliveira R, Williams D, Azeredo J. Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Med Mycol. 2009; 47(7): 681-9[DOI][PubMed]
  • 58. Nobile CJ, Nett JE, Hernday AD, Homann OR, Deneault JS, Nantel A, et al. Biofilm matrix regulation by Candida albicans Zap1. PLoS Biol. 2009; 7(6): 1000133[DOI][PubMed]
  • 59. Fauvart M, De Groote VN, Michiels J. Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies. J Med Microbiol. 2011; 60: 699-709[DOI][PubMed]
  • 60. Lewis K. Persister cells. Annu Rev Microbiol. 2010; 64: 357-72[DOI][PubMed]
  • 61. Al-Dhaheri RS, Douglas LJ. Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species. Antimicrob Agents Chemother. 2008; 52(5): 1884-7[DOI][PubMed]
  • 62. Chandra S, Dey P, Bhattacharya S. Preliminary in vitro assessment of anti-inflammatory property of Mikania scandens flower extract. J Adv Pharm Edu Res. 2012; 2(1): 25-31
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