Jundishapur Journal of Microbiology

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NDM-1 and rmtC-Producing Klebsiella pneumoniae Isolates in Turkey

Tulin Guven Gokmen 1 , * , Togrul Nagiyev 2 , Melda Meral 2 , Cansu Onlen 2 , Farzad Heydari 2 and Fatih Koksal 2
Authors Information
1 Department of Microbiology, Ceyhan Veterinary Faculty, Cukurova University, Adana, Turkey
2 Department of Medical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey
Article information
  • Jundishapur Journal of Microbiology: October 01, 2016, 9 (10); e33990
  • Published Online: September 18, 2016
  • Article Type: Research Article
  • Received: October 26, 2015
  • Revised: August 15, 2016
  • Accepted: August 23, 2016
  • DOI: 10.5812/jjm.33990

To Cite: Guven Gokmen T, Nagiyev T, Meral M, Onlen C, Heydari F, et al. NDM-1 and rmtC-Producing Klebsiella pneumoniae Isolates in Turkey, Jundishapur J Microbiol. 2016 ; 9(10):e33990. doi: 10.5812/jjm.33990.

Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011; 53(1): 60-7[DOI][PubMed]
  • 2. Hussein K, Sprecher H, Mashiach T, Oren I, Kassis I, Finkelstein R. Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns. Infect Control Hosp Epidemiol. 2009; 30(7): 666-71[DOI][PubMed]
  • 3. Hu Y, Liu A, Vaudrey J, Vaiciunaite B, Moigboi C, McTavish SM, et al. Combinations of beta-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus. PLoS One. 2015; 10(2)[DOI][PubMed]
  • 4. Ramirez MS, Tolmasky ME. Aminoglycoside modifying enzymes. Drug Resist Updat. 2010; 13(6): 151-71[DOI][PubMed]
  • 5. Yokoyama K, Doi Y, Yamane K, Kurokawa H, Shibata N, Shibayama K, et al. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa. Lancet. 2003; 362(9399): 1888-93[DOI][PubMed]
  • 6. Galimand M, Courvalin P, Lambert T. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob Agents Chemother. 2003; 47(8): 2565-71[PubMed]
  • 7. Doi Y, Arakawa Y. 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin Infect Dis. 2007; 45(1): 88-94[DOI][PubMed]
  • 8. Poirel L, Lagrutta E, Taylor P, Pham J, Nordmann P. Emergence of metallo-beta-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Antimicrob Agents Chemother. 2010; 54(11): 4914-6[DOI][PubMed]
  • 9. Quiles MG, Rocchetti TT, Fehlberg LC, Kusano EJ, Chebabo A, Pereira RM, et al. Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates. Braz J Med Biol Res. 2015; 48(2): 174-7[DOI][PubMed]
  • 10. Zhang Y, Zhou H, Shen XQ, Shen P, Yu YS, Li LJ. Plasmid-borne armA methylase gene, together with blaCTX-M-15 and blaTEM-1, in a Klebsiella oxytoca isolate from China. J Med Microbiol. 2008; 57: 1273-6[DOI][PubMed]
  • 11. Hu F, Munoz-Price LS, DePascale D, Rivera JI, Doi Y. Klebsiella pneumoniae sequence type 11 isolate producing RmtG 16S rRNA methyltransferase from a patient in Miami, Florida. Antimicrob Agents Chemother. 2014; 58(8): 4980-1[DOI][PubMed]
  • 12. Breakpoint tables for interpretation of MICs and zone diameters. 2009;
  • 13. Correa LL, Montezzi LF, Bonelli RR, Moreira BM, Picao RC. Revised and updated multiplex PCR targeting acquired 16S rRNA methyltransferases. Int J Antimicrob Agents. 2014; 43(5): 479-81[DOI][PubMed]
  • 14. Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011; 70(1): 119-23[DOI][PubMed]
  • 15. Dallenne C, Da Costa A, Decre D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010; 65(3): 490-5[DOI][PubMed]
  • 16. Voets GM, Fluit AC, Scharringa J, Cohen Stuart J, Leverstein-van Hall MA. A set of multiplex PCRs for genotypic detection of extended-spectrum beta-lactamases, carbapenemases, plasmid-mediated AmpC beta-lactamases and OXA beta-lactamases. Int J Antimicrob Agents. 2011; 37(4): 356-9[DOI][PubMed]
  • 17. Tamma PD, Cosgrove SE, Maragakis LL. Combination therapy for treatment of infections with gram-negative bacteria. Clin Microbiol Rev. 2012; 25(3): 450-70[DOI][PubMed]
  • 18. Le J, McKee B, Srisupha-Olarn W, Burgess DS. In vitro activity of carbapenems alone and in combination with amikacin against KPC-producing Klebsiella pneumoniae. J Clin Med Res. 2011; 3(3): 106-10[DOI][PubMed]
  • 19. Clancy CJ, Hao B, Shields RK, Chen L, Perlin DS, Kreiswirth BN, et al. Doripenem, gentamicin, and colistin, alone and in combinations, against gentamicin-susceptible, KPC-producing Klebsiella pneumoniae strains with various ompK36 genotypes. Antimicrob Agents Chemother. 2014; 58(6): 3521-5[DOI][PubMed]
  • 20. Wu Q, Liu Q, Han L, Sun J, Ni Y. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China. Diagn Microbiol Infect Dis. 2010; 66(3): 326-8[DOI][PubMed]
  • 21. Yamane K, Wachino J, Suzuki S, Shibata N, Kato H, Shibayama K, et al. 16S rRNA methylase-producing, gram-negative pathogens, Japan. Emerg Infect Dis. 2007; 13(4): 642-6[DOI][PubMed]
  • 22. Lee CS, Hu F, Rivera JI, Doi Y. Escherichia coli sequence type 354 coproducing CMY-2 cephalosporinase and RmtE 16S rRNA methyltransferase. Antimicrob Agents Chemother. 2014; 58(7): 4246-7[DOI][PubMed]
  • 23. Yang J, Ye L, Wang W, Luo Y, Zhang Y, Han L. Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates. Int J Antimicrob Agents. 2011; 38(4): 348-51[DOI][PubMed]
  • 24. Al Sheikh YA, Marie MA, John J, Krishnappa LG, Dabwab KH. Prevalence of 16S rRNA methylase genes among beta-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia. Libyan J Med. 2014; 9: 24432[DOI][PubMed]
  • 25. Fritsche TR, Castanheira M, Miller GH, Jones RN, Armstrong ES. Detection of methyltransferases conferring high-level resistance to aminoglycosides in enterobacteriaceae from Europe, North America, and Latin America. Antimicrob Agents Chemother. 2008; 52(5): 1843-5[DOI][PubMed]
  • 26. Hidalgo L, Hopkins KL, Gutierrez B, Ovejero CM, Shukla S, Douthwaite S, et al. Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. J Antimicrob Chemother. 2013; 68(7): 1543-50[DOI][PubMed]
  • 27. O'Hara JA, McGann P, Snesrud EC, Clifford RJ, Waterman PE, Lesho EP, et al. Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma. Antimicrob Agents Chemother. 2013; 57(5): 2413-6[DOI][PubMed]
  • 28. Ermertcan S, Yilmaz FF, Taşli H, Yurtman AN, Aydemir SS, Limoncu MH. Investigation of plasmid mediated methylase genes in aminoglycoside resistant gram negative bacteria. Türk Mikrobiyol Cem Derg. 2013; 43(1): 12-6[DOI]
  • 29. Ermertcan S, Hoşgör Limoncu M, Taşlı H, Eraç B, Gazi H. Gram negatif bakterilerde plazmid aracılı yüksek düzey aminoglikozit direncinin araştırılması. İnfeks Derg 2008; 22: 203-7
  • 30. Bercot B, Poirel L, Ozdamar M, Hakko E, Turkoglu S, Nordmann P. Low prevalence of 16S methylases among extended-spectrum-beta-lactamase-producing Enterobacteriaceae from a Turkish hospital. J Antimicrob Chemother. 2010; 65(4): 797-8[DOI][PubMed]
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