Jundishapur Journal of Microbiology

Published by: Kowsar

Prevalence of Influenza A(H1N1)pdm09 Virus Resistant to Oseltamivir in Shiraz, Iran, During 2012 - 2013

Nastaran Khodadad 1 , Afagh Moattari 1 , * , Mahmoud Shamsi Shahr Abadi 2 , Mohammad Rahim Kadivar 3 , Jamal Sarvari 1 , Forough Tavakoli 1 , Neda Pirbonyeh 1 and Amir Emami 1
Authors Information
1 Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Virology, Tehran University of Medical Sciences, Tehran, IR Iran
3 Department of Pediatrics, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Jundishapur Journal of Microbiology: August 01, 2015, 8 (8); e23690
  • Published Online: August 29, 2015
  • Article Type: Research Article
  • Received: September 24, 2014
  • Revised: November 16, 2014
  • Accepted: January 21, 2015
  • DOI: 10.5812/jjm.23690

To Cite: Khodadad N, Moattari A, Shamsi Shahr Abadi M, Kadivar M R, Sarvari J, et al. Prevalence of Influenza A(H1N1)pdm09 Virus Resistant to Oseltamivir in Shiraz, Iran, During 2012 - 2013, Jundishapur J Microbiol. 2015 ; 8(8):e23690. doi: 10.5812/jjm.23690.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Yavarian J, Azad TM, Zheng X, Gregory V, Lin YP, Hay A. Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran. Antiviral Res. 2010; 88(2): 193-6[DOI][PubMed]
  • 2. Zaraket H, Kondo H, Tabet C, Hanna-Wakim R, Suzuki Y, Dbaibo GS, et al. Genetic diversity and antiviral drug resistance of pandemic H1N1 2009 in Lebanon. J Clin Virol. 2011; 51(3): 170-4[DOI][PubMed]
  • 3. Bai GR, Chittaganpitch M, Kanai Y, Li YG, Auwanit W, Ikuta K, et al. Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand. Biochem Biophys Res Commun. 2009; 390(3): 897-901[DOI][PubMed]
  • 4. Moradi A, Nadji SA, Tabarsi P, Hashemian SM, Marjani M, Sigaroodi A, et al. Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran. Tanaffos. 2011; 10(1): 8-11[PubMed]
  • 5. Monto AS. The role of antivirals in the control of influenza. Vaccine. 2003; 21(16): 1796-800[PubMed]
  • 6. Dapat C, Suzuki Y, Kon M, Tamura T, Saito R, Dapat IC, et al. Phylogenetic analysis of an off-seasonal influenza virus A (H3N2) in Niigata, Japan, 2010. Jpn J Infect Dis. 2011; 64(3): 237-41[PubMed]
  • 7. Pontoriero A, Baumeister E, Campos AM, Savy VL. Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008. Rev Panam Salud Publica. 2011; 30(6): 634-40[PubMed]
  • 8. Gioula G, Melidou A, Exindari M, Papoutsi N, Chatzidimitriou D, Dotis J, et al. Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus in Northern Greece. Hippokratia. 2011; 15(3): 272-4[PubMed]
  • 9. Nguyen HT, Trujillo AA, Sheu TG, Levine M, Mishin VP, Shaw M, et al. Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res. 2012; 93(3): 381-6[DOI][PubMed]
  • 10. Takayama I, Nakauchi M, Fujisaki S, Odagiri T, Tashiro M, Kageyama T. Rapid detection of the S247N neuraminidase mutation in influenza A(H1N1)pdm09 virus by one-step duplex RT-PCR assay. J Virol Methods. 2013; 188(1-2): 73-5[DOI][PubMed]
  • 11. Dapat IC, Dapat C, Baranovich T, Suzuki Y, Kondo H, Shobugawa Y, et al. Genetic characterization of human influenza viruses in the pandemic (2009-2010) and post-pandemic (2010-2011) periods in Japan. PLoS One. 2012; 7(6)[DOI][PubMed]
  • 12. Merten OW, Manuguerra JC, Hannoun C, van der Werf S. Production of influenza virus in serum-free mammalian cell cultures. Dev Biol Stand. 1999; 98: 23-37[PubMed]
  • 13. Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, et al. Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem J. 2002; 367: 413-22[DOI][PubMed]
  • 14. Finney DJ. Statistical method in biological assay. 1952;
  • 15. Jacks A, Ollgren J, Ziegler T, Lyytikainen O. Influenza-associated hospitalisations in Finland from 1996 to 2010: unexpected age-specific burden during the influenza A(H1N1)pdm09 pandemic from 2009 to 2010. Euro Surveill. 2012; 17(38)[PubMed]
  • 16. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013; 30(12): 2725-9[DOI][PubMed]
  • 17. Takashita E, Ejima M, Itoh R, Miura M, Ohnishi A, Nishimura H, et al. A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013. Euro Surveill. 2014; 19(1): 20666[DOI]
  • 18. Souza TM, Resende PC, Fintelman-Rodrigues N, Gregianini TS, Ikuta N, Fernandes SB, et al. Detection of oseltamivir-resistant pandemic influenza A(H1N1)pdm2009 in Brazil: can community transmission be ruled out? PLoS One. 2013; 8(11)[DOI][PubMed]
  • 19. Ramirez-Gonzalez JE, Gonzalez-Duran E, Alcantara-Perez P, Wong-Arambula C, Olivera-Diaz H, Cortez-Ortiz I, et al. Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico. Emerg Infect Dis. 2011; 17(2): 283-6[DOI][PubMed]
  • 20. Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009; 325(5937): 197-201[DOI][PubMed]
  • 21. Ziyaeyan M, Alborzi A, Jamalidoust M, Moeini M, Pouladfar GR, Pourabbas B, et al. Pandemic 2009 influenza A (H1N1) infection among 2009 Hajj Pilgrims from Southern Iran: a real-time RT-PCR-based study. Influenza Other Respir Viruses. 2012; 6(6)-4[DOI][PubMed]
  • 22. Fang Q, Gao Y, Chen M, Guo X, Yang X, Yang X, et al. Molecular epidemiology and evolution of A(H1N1)pdm09 and H3N2 virus during winter 2012-2013 in Beijing, China. Infect Genet Evol. 2014; 26: 228-40[DOI][PubMed]
  • 23. Hoang Vu MP, Nguyen CT, Nguyen le KH, Nguyen TK, Le QM. Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009-2012. Western Pac Surveill Response J. 2013; 4(2): 25-9[DOI][PubMed]
  • 24. Arvia R, Corcioli F, Simi L, Orlando C, De Santis R, Facchini M, et al. Monitoring the susceptibility to oseltamivir of Influenza A(H1N1) 2009 virus by nested-PCR and pyrosequencing during the pandemic and in the season 2010-2011. J Virol Methods. 2012; 184(1-2): 113-6[DOI][PubMed]
  • 25. Tarbet EB, Vollmer AH, Hurst BL, Barnard DL, Furuta Y, Smee DF. In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus. Arch Virol. 2014; 159(6): 1279-91[DOI][PubMed]
  • 26. Oh DY, Hurt AC. A Review of the Antiviral Susceptibility of Human and Avian Influenza Viruses over the Last Decade. Scientifica (Cairo). 2014; 2014: 430629[DOI][PubMed]
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