Jundishapur Journal of Microbiology

Published by: Kowsar

Vaginal Protection by H2O2-Producing Lactobacilli

Andrey V. Sgibnev 1 , * and Elena A. Kremleva 1
Authors Information
1 Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia
Article information
  • Jundishapur Journal of Microbiology: October 01, 2015, 8 (10); e22913
  • Published Online: October 17, 2015
  • Article Type: Brief Report
  • Received: August 22, 2014
  • Revised: January 16, 2015
  • Accepted: February 5, 2015
  • DOI: 10.5812/jjm.22913

To Cite: V. Sgibnev A, A. Kremleva E. Vaginal Protection by H2O2-Producing Lactobacilli, Jundishapur J Microbiol. 2015 ; 8(10):e22913. doi: 10.5812/jjm.22913.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Dover SE, Aroutcheva AA, Faro S, Chikindas ML. Natural Antimicrobials and Their Role in Vaginal Health: A Short Review. Int J Probiotics Prebiotics. 2008; 3(4): 219-30[PubMed]
  • 2. Spurbeck RR, Arvidson CG. Lactobacilli at the front line of defense against vaginally acquired infections. Future Microbiol. 2011; 6(5): 567-82[DOI][PubMed]
  • 3. Nardis C, Mosca L, Mastromarino P. Vaginal microbiota and viral sexually transmitted diseases. Ann Ig. 2013; 25(5): 443-56[PubMed]
  • 4. Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect. 2000; 2(5): 543-6[PubMed]
  • 5. Matu MN, Orinda GO, Njagi EN, Cohen CR, Bukusi EA. In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women. Anaerobe. 2010; 16(3): 210-5[DOI][PubMed]
  • 6. Klebanoff SJ, Hillier SL, Eschenbach DA, Waltersdorph AM. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. J Infect Dis. 1991; 164(1): 94-100[PubMed]
  • 7. Vallor AC, Antonio MA, Hawes SE, Hillier SL. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production. J Infect Dis. 2001; 184(11): 1431-6[DOI][PubMed]
  • 8. Beigi RH, Wiesenfeld HC, Hillier SL, Straw T, Krohn MA. Factors associated with absence of H2O2-producing Lactobacillus among women with bacterial vaginosis. J Infect Dis. 2005; 191(6): 924-9[DOI][PubMed]
  • 9. Strus M, Brzychczy-Wloch M, Gosiewski T, Kochan P, Heczko PB. The in vitro effect of hydrogen peroxide on vaginal microbial communities. FEMS Immunol Med Microbiol. 2006; 48(1): 56-63[DOI][PubMed]
  • 10. Gong Z, Luna Y, Yu P, Fan H. Lactobacilli inactivate Chlamydia trachomatis through lactic acid but not H2O2. PLoS One. 2014; 9(9)[DOI][PubMed]
  • 11. Robinson CJ, Bohannan BJ, Young VB. From structure to function: the ecology of host-associated microbial communities. Microbiol Mol Biol Rev. 2010; 74(3): 453-76[DOI][PubMed]
  • 12. Amjadi F, Salehi E, Mehdizadeh M, Aflatoonian R. Role of the innate immunity in female reproductive tract. Adv Biomed Res. 2014; 3: 1[DOI][PubMed]
  • 13. Quayle AJ. The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. J Reprod Immunol. 2002; 57(1-2): 61-79[PubMed]
  • 14. Wira CR, Grant-Tschudy KS, Crane-Godreau MA. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am J Reprod Immunol. 2005; 53(2): 65-76[DOI][PubMed]
  • 15. Cole AM. Innate host defense of human vaginal and cervical mucosae. Curr Top Microbiol Immunol. 2006; 306: 199-230[PubMed]
  • 16. Martin R, Suarez JE. Biosynthesis and degradation of H2O2 by vaginal lactobacilli. Appl Environ Microbiol. 2010; 76(2): 400-5[DOI][PubMed]
  • 17. Glantz SA. Primer of biostatistics. 2002;
  • 18. Pahlson C, Larsson PG. The ecologically wrong vaginal lactobacilli. Med Hypotheses. 1991; 36(2): 126-30[PubMed]
  • 19. Motevaseli E, Shirzad M, Raoofian R, Hasheminasab SM, Hatami M, Dianatpour M, et al. Differences in vaginal lactobacilli composition of Iranian healthy and bacterial vaginosis infected women: a comparative analysis of their cytotoxic effects with commercial vaginal probiotics. Iran Red Crescent Med J. 2013; 15(3): 199-206[DOI][PubMed]
  • 20. O'Hanlon DE, Moench TR, Cone RA. In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide. BMC Infect Dis. 2011; 11: 200[DOI][PubMed]
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