Jundishapur Journal of Microbiology

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Effect of Propranolol Alone and in Combination with Pyrimethamine on Acute Murine Toxoplasmosis

Mahbobeh Montazeri 1 , 2 , Ahmad Daryani 1 , 2 , * , Mohammadali Ebrahimzadeh 3 , Ehsan Ahmadpour 4 , Mehdi Sharif 1 , 2 and Shahabeddin Sarvi 1 , 2
Authors Information
1 Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran
2 Department of Parasitology and Mycology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences Sari, IR Iran
4 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Jundishapur Journal of Microbiology: September 01, 2015, 8 (9); e22572
  • Published Online: September 7, 2015
  • Article Type: Research Article
  • Received: August 6, 2014
  • Revised: December 3, 2014
  • Accepted: January 26, 2015
  • DOI: 10.5812/jjm.22572

To Cite: Montazeri M, Daryani A, Ebrahimzadeh M, Ahmadpour E, Sharif M, et al. Effect of Propranolol Alone and in Combination with Pyrimethamine on Acute Murine Toxoplasmosis, Jundishapur J Microbiol. 2015 ; 8(9):e22572. doi: 10.5812/jjm.22572.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Petersen E. Toxoplasmosis. Semin Fetal Neonatal Med. 2007; 12(3): 214-23[DOI][PubMed]
  • 2. Weiss LM, Dubey JP. Toxoplasmosis: A history of clinical observations. Int J Parasitol. 2009; 39(8): 895-901[DOI][PubMed]
  • 3. Weiss LM, Kim K. Toxoplasma gondii: the model apicomplexan. Perspectives and methods. 2011;
  • 4. Ambroise-Thomas P, Pelloux H. Toxoplasmosis - congenital and in immunocompromised patients: a parallel. Parasitol Today. 1993; 9(2): 61-3[PubMed]
  • 5. Serranti D, Buonsenso D, Valentini P. [Congenital toxoplasmosis treatment]. Eur Rev Med Pharmacol Sci. 2011; 15(2): 193-8[PubMed]
  • 6. Al-Zanbagi NA. Effectiveness of Myrrh and Spiramycin as Inhibitors for Toxoplasma gondii Tachyzoites in vivo. Mansoura J Forensic Med Clin Toxicol. 2007; 15(2): 117-28
  • 7. Araujo FG, Remington JS. Recent advances in the search for new drugs for treatment of toxoplasmosis. Int J Antimicrob Agents. 1992; 1(4): 153-64[PubMed]
  • 8. Ryning FW, Remington JS. Effect of cytochalasin D on Toxoplasma gondii cell entry. Infect Immun. 1978; 20(3): 739-43[PubMed]
  • 9. Morisaki JH, Heuser JE, Sibley LD. Invasion of Toxoplasma gondii occurs by active penetration of the host cell. J Cell Sci. 1995; 108 ( Pt 6): 2457-64[PubMed]
  • 10. D'Angelo JG, Bordon C, Posner GH, Yolken R, Jones-Brando L. Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle. J Antimicrob Chemother. 2009; 63(1): 146-50[DOI][PubMed]
  • 11. Daryani A, Ebrahimzadeh MA, Sharif M, Rezaei F, Ahmadpour E, Sarvi S. The inhibitory effect of ketotifen on entrance of Toxoplasma gondii tachyzoites into macrophages of mouse. J Mazandaran Univ Med Sci. 2014; 23(110): 75-80
  • 12. Daryani A, Hosseini AZ, Dalimi A. Immune responses against excreted/secreted antigens of Toxoplasma gondii tachyzoites in the murine model. Vet Parasitol. 2003; 113(2): 123-34[PubMed]
  • 13. Yang CD, Chang GN, Chao D. Protective immunity against Toxoplasma gondii in mice induced by the SAG2 internal image of anti-idiotype antibody. Parasitol Res. 2003; 91(6): 452-7[DOI][PubMed]
  • 14. Dadimoghaddam Y, Daryani A, Sharif M, Ahmadpour E, Hossienikhah Z. Tissue tropism and parasite burden of Toxoplasma gondii RH strain in experimentally infected mice. Asian Pac J Trop Med. 2014; 7(7): 521-4[DOI][PubMed]
  • 15. Langslet A. Membrane stabilization and cardiac effects of d,1-propranolol, d-propranolol and chlorpromazine. Eur J Pharmacol. 1970; 13(1): 6-14[PubMed]
  • 16. Martins-Duarte ES, de Souza W, Vommaro RC. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013; 133(3): 294-9[DOI][PubMed]
  • 17. Fung HB, Kirschenbaum HL. Treatment regimens for patients with toxoplasmic encephalitis. Clin Ther. 1996; 18(6): 1037-56[PubMed]
  • 18. Foppa CU, Bini T, Gregis G, Lazzarin A, Esposito R, Moroni M. A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. Eur J Clin Microbiol Infect Dis. 1991; 10(3): 187-9[PubMed]
  • 19. Ohnishi ST, Sadanaga KK, Katsuoka M, Weidanz WP. Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes. Mol Cell Biochem. 1989; 91(1-2): 159-65[PubMed]
  • 20. Singh N, Puri SK. Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. Acta Trop. 2000; 77(2): 185-93[PubMed]
  • 21. Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K. Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006; 3(12)[DOI][PubMed]
  • 22. Manninen V. Movements of sodium and potassium ions and their tracers in propranolol-treated red cells and diaphragm muscle. Acta Physiol Scand Suppl. 1970; 355: 1-76[PubMed]
  • 23. Porter RS, Kaplan JL. The Merck manual of diagnosis and therapy.
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