Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression

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To Cite : Nasrollahi Z, Yadegari M H, Roudbar Mohammadi S, Roudbary M, Hosseini Poor M, et al. Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression, Jundishapur J Microbiol. 2015 ;8(9):e21468. doi: 10.5812/jjm.21468.
1. Background
2. Objectives
3. Patients and Methods
4. Results and Discussion
  • 1. Sobel JD. Vaginitis. N Engl J Med. 1997; 337(26): 1896-903[DOI][PubMed]
  • 2. Sobel JD. Candida vulvovaginitis. Semin Dermatol. 1996; 15(1): 17-28[PubMed]
  • 3. Lynch ME, Sobel JD, Fidel PJ. Role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasis. J Med Vet Mycol. 1996; 34(5): 337-9[PubMed]
  • 4. MacNeill C, Weisz J, Carey JC. Clinical resistance of recurrent Candida albicans vulvovaginitis to fluconazole in the presence and absence of in vitro resistance. J Reprod Med. 2003; 48(2): 63-8[PubMed]
  • 5. Bodey GP. Azole antifungal agents. Clin Infect Dis. 1992; 14 Suppl 1-9[PubMed]
  • 6. Lynch ME, Sobel JD. Comparative in vitro activity of antimycotic agents against pathogenic vaginal yeast isolates. J Med Vet Mycol. 1994; 32(4): 267-74[PubMed]
  • 7. Lupetti A, Danesi R, Campa M, Del Tacca M, Kelly S. Molecular basis of resistance to azole antifungals. Trends Mol Med. 2002; 8(2): 76-81[PubMed]
  • 8. Martinez AI, Castillo L, Garcera A, Elorza MV, Valentin E, Sentandreu R. Role of Pir1 in the construction of the Candida albicans cell wall. Microbiology. 2004; 150: 3151-61[DOI][PubMed]
  • 9. Sorgo AG, Heilmann CJ, Dekker HL, Bekker M, Brul S, de Koster CG, et al. Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell. 2011; 10(8): 1071-81[DOI][PubMed]
  • 10. Sosinska GJ, de Groot PW, Teixeira de Mattos MJ, Dekker HL, de Koster CG, Hellingwerf KJ, et al. Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology. 2008; 154: 510-20[DOI][PubMed]
  • 11. Segal E, Elad D. Candida species and Blastoschizomyces capitatus. Topley Wilson’s Microbiol Microb Infect. 1998; 4: 423-60
  • 12. May JL, King A, Warren CA. Fluconazole disc diffusion testing for the routine laboratory. J Antimicrob Chemother. 1997; 40(4): 511-6[PubMed]
  • 13. Mohanty S, Xess I, Hasan F, Kapil A, Mittal S, Tolosa JE. Prevalence & susceptibility to fluconazole of Candida species causing vulvovaginitis. Indian J Med Res. 2007; 126(3): 216-9[PubMed]
  • 14. Lotz H, Sohn K, Brunner H, Muhlschlegel FA, Rupp S. RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1. Eukaryot Cell. 2004; 3(3): 776-84[DOI][PubMed]
  • 15. Angiolella L, Micocci MM, D'Alessio S, Girolamo A, Maras B, Cassone A. Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance. Antimicrob Agents Chemother. 2002; 46(6): 1688-94[PubMed]
  • 16. Hazen KC, Mandell G, Coleman E, Wu G. Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans. FEMS Microbiol Lett. 2000; 183(1): 89-94[PubMed]
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