Jundishapur Journal of Microbiology

Published by: Kowsar

Extracellular Enzymes and Susceptibility to Fluconazole in Candida Strains Isolated From Patients With Vaginitis and Healthy Individuals

Zahra Seifi 1 , Ali Zarei Mahmoudabadi 1 , 2 , * and Majid Zarrin 1
Authors Information
1 Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Health Research Institute, Infectious and Tropical Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Microbiology: March 01, 2015, 8 (3); e20162
  • Published Online: March 21, 2015
  • Article Type: Research Article
  • Received: May 12, 2014
  • Revised: June 16, 2014
  • Accepted: June 20, 2014
  • DOI: 10.5812/jjm.20162

To Cite: Seifi Z, Zarei Mahmoudabadi A, Zarrin M. Extracellular Enzymes and Susceptibility to Fluconazole in Candida Strains Isolated From Patients With Vaginitis and Healthy Individuals, Jundishapur J Microbiol. 2015 ; 8(3):e20162. doi: 10.5812/jjm.20162.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Rasti S, Asadi MA, Taghriri A, Behrashi M, Mousavie G. Vaginal candidiasis complications on pregnant women. Jundishapur J Microbiol. 2014; 7(2)[DOI][PubMed]
  • 2. Mahmoudabadi AZ, Najafyan M, Moghimipour E, Alwanian M, Seifi Z. Lamisil versus clotrimazole in the treatment of vulvovaginal candidiasis. Iran J Microbiol. 2013; 5(1): 86-90[PubMed]
  • 3. Mohanty S, Xess I, Hasan F, Kapil A, Mittal S, Tolosa JE. Prevalence & susceptibility to fluconazole of Candida species causing vulvovaginitis. Indian J Med Res. 2007; 126(3): 216-9[PubMed]
  • 4. Mahmoudabadi AZ, Najafyan M, Alidadi M. Clinical study of Candida vaginitis in Ahvaz, Iran and susceptibility of agents to topical antifungal. Pak J Med Sci. 2010; 26(3): 607-10
  • 5. Rodrigues AG, Pina-Vaz C, Costa-de-Oliveira S, Tavares C. Expression of plasma coagulase among pathogenic Candida species. J Clin Microbiol. 2003; 41(12): 5792-3[PubMed]
  • 6. Sun X, Lu H, Jiang Y, Cao Y. CaIPF19998 reduces drug susceptibility by enhancing the ability of biofilm formation and regulating redox homeostasis in Candida albicans. Curr Microbiol. 2013; 67(3): 322-6[DOI][PubMed]
  • 7. Jin Y, Samaranayake YH, Yip HK, Samaranayake LP. Characterization of switch phenotypes in Candida albicans biofilms. Mycopathologia. 2005; 160(3): 191-200[DOI][PubMed]
  • 8. Gokce G, Cerikcioglu N, Yagci A. Acid proteinase, phospholipase, and biofilm production of Candida species isolated from blood cultures. Mycopathologia. 2007; 164(6): 265-9[DOI][PubMed]
  • 9. Sekhavat L, Tabatabaii A, Tezerjani FZ. Oral fluconazole 150 mg single dose versus intra-vaginal clotrimazole treatment of acute vulvovaginal candidiasis. J Infect Public Health. 2011; 4(4): 195-9[DOI][PubMed]
  • 10. Pinto E, Ribeiro IC, Ferreira NJ, Fortes CE, Fonseca PA, Figueiral MH. Correlation between enzyme production, germ tube formation and susceptibility to fluconazole in Candida species isolated from patients with denture-related stomatitis and control individuals. J Oral Pathol Med. 2008; 37(10): 587-92[DOI][PubMed]
  • 11. Marchaim D, Lemanek L, Bheemreddy S, Kaye KS, Sobel JD. Fluconazole-resistant Candida albicans vulvovaginitis. Obstet Gynecol. 2012; 120(6): 1407-14[PubMed]
  • 12. Danby CS, Boikov D, Rautemaa-Richardson R, Sobel JD. Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use. Antimicrob Agents Chemother. 2012; 56(3): 1403-6[DOI][PubMed]
  • 13. Ge YP, Lu GX, Shen YN, Liu WD. In vitro evaluation of phospholipase, proteinase, and esterase activities of Candida parapsilosis and Candida metapsilosis. Mycopathologia. 2011; 172(6): 429-38[DOI][PubMed]
  • 14. Mahmoudabadi AZ, Zarrin M, Miry S. Phospholipase activity of Candida albicans isolated from vagina and urine samples. Jundishapur J Microbiol. 2007; 3(4): 169-73
  • 15. Ombrella AM, Racca L, Ramos L. [Protease and phospholipase activities of Candida albicans isolated from vaginal secretions with different pH values]. Rev Iberoam Micol. 2008; 25(1): 12-6[PubMed]
  • 16. Yigit N, Aktas E, Dagistan S, Ayyildiz A. Investigating biofilm production, coagulase and hemolytic activity in Candida species isolated from denture stomatitis patients. Eurasian J Med. 2011; 43(1): 27-32[DOI][PubMed]
  • 17. Instruction for ATBTM Fungus bS. 2011;
  • 18. Tay ST, Abidin IA, Hassan H, Ng KP. Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures. Med Mycol. 2011; 49(5): 556-60[DOI][PubMed]
  • 19. Ibrahim AS, Mirbod F, Filler SG, Banno Y, Cole GT, Kitajima Y, et al. Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect Immun. 1995; 63(5): 1993-8[PubMed]
  • 20. Vidotto V, Yumi Koga-Ito C, Milano R, Fianchino B, Ponton J. Correlation between germ tube production, phospholipase activity and serotype distribution in Candida albicans. Rev Iberoam Micol. 1999; 16(4): 208-10[PubMed]
  • 21. Kantarcioglu AS, Yucel A. Phospholipase and protease activities in clinical Candida isolates with reference to the sources of strains. Mycoses. 2002; 45(5-6): 160-5[PubMed]
  • 22. Yigit N, Aktas AE, Ayyildiz A. Detection of coagulase activity in pathogenic Candida species. J Int Med Res. 2008; 36(6): 1378-82[PubMed]
  • 23. Mahmoudi Rad M, Zafarghandi S, Abbasabadi B, Tavallaee M. The epidemiology of Candida species associated with vulvovaginal candidiasis in an Iranian patient population. Eur J Obstet Gynecol Reprod Biol. 2011; 155(2): 199-203[DOI][PubMed]
  • 24. da Costa KR, Ferreira JC, Komesu MC, Candido RC. Candida albicans and Candida tropicalis in oral candidosis: quantitative analysis, exoenzyme activity, and antifungal drug sensitivity. Mycopathologia. 2009; 167(2): 73-9[DOI][PubMed]
  • 25. Richter SS, Galask RP, Messer SA, Hollis RJ, Diekema DJ, Pfaller MA. Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases. J Clin Microbiol. 2005; 43(5): 2155-62[DOI][PubMed]
  • 26. Sojakova M, Liptajova D, Borovsky M, Subik J. Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia. Mycopathologia. 2004; 157(2): 163-9[PubMed]
  • 27. Kumar R, Shukla PK. Amphotericin B resistance leads to enhanced proteinase and phospholipase activity and reduced germ tube formation in Candida albicans. Fungal Biol. 2010; 114(2-3): 189-97[DOI][PubMed]
  • 28. Lyon JP, de Resende MA. Correlation between adhesion, enzyme production, and susceptibility to fluconazole in Candida albicans obtained from denture wearers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(5): 632-8[DOI][PubMed]
  • 29. Kecli K, Budak F, Lden SG, Tamer N, Willke A. An investigation on the antifungal susceptibility and phospholipase activity of Candida species. infection Mag. 2003; 17(3): 321-4
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments