Jundishapur Journal of Microbiology

Published by: Kowsar

Phenotypic and Molecular Epidemiology of Acinetobactercalcoaceticusbaumannii Complex Strains Spread at Nemazee Hospital of Shiraz, Iran

Mojtaba Anvarinejad 1 , Aziz Japoni 1 , Mohammad Ali Davarpanah 2 , Hossein Mahmudi 3 , Caterina Mammina 4 and Afsaneh Vazin 3 , *
Authors Information
1 Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Sciences for Health Promotion “G. D’Alessandro”, Palermo, Italy
Article information
  • Jundishapur Journal of Microbiology: June 01, 2015, 8 (6); e19180
  • Published Online: June 20, 2015
  • Article Type: Research Article
  • Received: April 5, 2014
  • Revised: November 9, 2014
  • Accepted: November 24, 2014
  • DOI: 10.5812/jjm.8(5)2015.19180

To Cite: Anvarinejad M, Japoni A, Davarpanah M A, Mahmudi H, Mammina C, et al. Phenotypic and Molecular Epidemiology of Acinetobactercalcoaceticusbaumannii Complex Strains Spread at Nemazee Hospital of Shiraz, Iran, Jundishapur J Microbiol. 2015 ; 8(6):e19180. doi: 10.5812/jjm.8(5)2015.19180.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Blossom DB, Srinivasan A. Drug-Resistant Acinetobacter baumannii-calcoaceticus Complex. Infect Dis Clin Pract. 2008; 16(1): 1-3[DOI]
  • 2. Mussi MA, Gaddy JA, Cabruja M, Arivett BA, Viale AM, Rasia R, et al. The opportunistic human pathogen Acinetobacter baumannii senses and responds to light. J Bacteriol. 2010; 192(24): 6336-45[DOI][PubMed]
  • 3. Rungruanghiranya S, Somboonwit C, Kanchanapoom T. Acinetobacter infection in the intensive care unit. J Infect Dis Antimicrob Agents. 2005; 22(2): 77-92
  • 4. Sydnor ER, Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011; 24(1): 141-73[DOI][PubMed]
  • 5. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. 2008; 21(3): 538-82[DOI][PubMed]
  • 6. Fishbain J, Peleg AY. Treatment of Acinetobacter infections. Clin Infect Dis. 2010; 51(1): 79-84[DOI][PubMed]
  • 7. Sunenshine RH, Wright MO, Maragakis LL, Harris AD, Song X, Hebden J, et al. Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis. 2007; 13(1): 97-103[DOI][PubMed]
  • 8. Cetin ES, Durmaz R, Tetik T, Otlu B, Kaya S, Caliskan A. Epidemiologic characterization of nosocomial Acinetobacter baumannii infections in a Turkish university hospital by pulsed-field gel electrophoresis. Am J Infect Control. 2009; 37(1): 56-64[DOI][PubMed]
  • 9. Alfizah H, Nordiah AJ, Rozaidi WS. Using pulsed-field gel electrophoresis in the molecular investigation of an outbreak of Serratia marcescens infection in an intensive care unit. Singapore Med J. 2004; 45(5): 214-8[PubMed]
  • 10. Migliavacca R, Espinal P, Principe L, Drago M, Fugazza G, Roca I, et al. Characterization of resistance mechanisms and genetic relatedness of carbapenem-resistant Acinetobacter baumannii isolated from blood, Italy. Diagn Microbiol Infect Dis. 2013; 75(2): 180-6[DOI][PubMed]
  • 11. Sonnevend A, Ghazawi A, Al Munthari N, Pitout M, Hamadeh MB, Hashmey R, et al. Characteristics of epidemic and sporadic strains of Acinetobacter baumannii isolated in Abu Dhabi hospitals. J Med Microbiol. 2013; 62: 582-90[DOI][PubMed]
  • 12. Izdebski R, Fiett J, Hryniewicz W, Gniadkowski M. Molecular analysis of Acinetobacter baumannii isolates from invasive infections in 2009 in Poland. J Clin Microbiol. 2012; 50(11): 3813-5[DOI][PubMed]
  • 13. Chang KC, Lin MF, Lin NT, Wu WJ, Kuo HY, Lin TY, et al. Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern Taiwan. J Microbiol Immunol Infect. 2012; 45(1): 37-42[DOI][PubMed]
  • 14. Heritier C, Poirel L, Fournier PE, Claverie JM, Raoult D, Nordmann P. Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob Agents Chemother. 2005; 49(10): 4174-9[DOI][PubMed]
  • 15. Cardoso T, Ribeiro O, Aragao IC, Costa-Pereira A, Sarmento AE. Additional risk factors for infection by multidrug-resistant pathogens in healthcare-associated infection: a large cohort study. BMC Infect Dis. 2012; 12: 375[DOI][PubMed]
  • 16. Performance standards for antimicrobial susceptibility testing: Sixteenth informational supplement. 2006; 26
  • 17. Seifert H, Dolzani L, Bressan R, van der Reijden T, van Strijen B, Stefanik D, et al. Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii. J Clin Microbiol. 2005; 43(9): 4328-35[DOI][PubMed]
  • 18. Dent LL, Marshall DR, Pratap S, Hulette RB. Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital. BMC Infect Dis. 2010; 10: 196[DOI][PubMed]
  • 19. Camp C,, Tatum OL. A Review of Acinetobacter calcoaceticus baumannii complex as a Highly Successful Pathogen in Times of War. Lab Med. 2010; 41(11): 649-57[DOI]
  • 20. Chang HC, Wei YF, Dijkshoorn L, Vaneechoutte M, Tang CT, Chang TC. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region. J Clin Microbiol. 2005; 43(4): 1632-9[DOI][PubMed]
  • 21. Shelburne S3, Singh KV, White AJ, Byrne L, Carmer A, Austin C, et al. Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, Texas. J Clin Microbiol. 2008; 46(1): 198-205[DOI][PubMed]
  • 22. Mohajeri P, Farahani A, Feizabadi MM, Ketabi H, Abiri R, Najafi F. Antimicrobial susceptibility profiling and genomic diversity of Acinetobacter baumannii isolates: A study in western Iran. Iran J Microbiol. 2013; 5(3): 195-202[PubMed]
  • 23. Corbella X, Montero A, Pujol M, Dominguez MA, Ayats J, Argerich MJ, et al. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol. 2000; 38(11): 4086-95[PubMed]
  • 24. Zarrilli R, Crispino M, Bagattini M, Barretta E, Di Popolo A, Triassi M, et al. Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance. J Clin Microbiol. 2004; 42(3): 946-53[PubMed]
  • 25. Shahcheraghi F, Abbasalipour M, Feizabadi M, Ebrahimipour G, Akbari N. Isolation and genetic characterization of metallo-beta-lactamase and carbapenamase producing strains of Acinetobacter baumannii from patients at Tehran hospitals. Iran J Microbiol. 2011; 3(2): 68-74[PubMed]
  • 26. Moniri R, Farahani RK, Shajari G, Shirazi MN, Ghasemi A. Molecular epidemiology of aminoglycosides resistance in acinetobacter spp. With emergence of multidrug-resistant strains. Iran J Public Health. 2010; 39(2): 63-8[PubMed]
  • 27. Peymani A, Farajnia S, Nahaei MR, Sohrabi N, Abbasi L, Ansarin K, et al. Prevalence of class 1 integron among multidrug-resistant Acinetobacter baumannii in Tabriz, northwest of Iran. Pol J Microbiol. 2012; 61(1): 57-60[PubMed]
  • 28. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007; 51(10): 3471-84[DOI][PubMed]
  • 29. Bahador A, Taheri M, Pourakbari B, Hashemizadeh Z, Rostami H, Mansoori N, et al. Emergence of rifampicin, tigecycline, and colistin-resistant Acinetobacter baumannii in Iran; spreading of MDR strains of novel International Clone variants. Microb Drug Resist. 2013; 19(5): 397-406[DOI][PubMed]
  • 30. Park YK, Peck KR, Cheong HS, Chung DR, Song JH, Ko KS. Extreme drug resistance in Acinetobacter baumannii infections in intensive care units, South Korea. Emerg Infect Dis. 2009; 15(8): 1325-7[PubMed]
  • 31. Villalon P, Valdezate S, Medina-Pascual MJ, Rubio V, Vindel A, Saez-Nieto JA. Clonal diversity of nosocomial epidemic Acinetobacter baumannii strains isolated in Spain. J Clin Microbiol. 2011; 49(3): 875-82[DOI][PubMed]
  • 32. Baadani AM, Thawadi SI, El-Khizzi NA, Omrani AS. Prevalence of colistin and tigecycline resistance in Acinetobacter baumannii clinical isolates from 2 hospitals in Riyadh Region over a 2-year period. Saudi Med J. 2013; 34(3): 248-53[PubMed]
  • 33. Goudarzi H, Douraghi M, Ghalavand Z, Goudarzi M. Assessment of antibiotic resistance pattern in Acinetobacter bumannii carrying bla oxA type genes isolated from hospitalized patients. Novelty in Biomedicine. 2013; 1(2): 54-61
  • 34. Japoni-Nejad A, Sofian M, Belkum A, Ghaznavi-Rad E. Nosocomial Outbreak of Extensively and Pan Drug-Resistant Acinetobacter baumannii in Tertiary Hospital in Central Part of Iran. JJM. 2013; 6(8): 1-5[DOI]
  • 35. Feizabadi MM, Fathollahzadeh B, Taherikalani M, Rasoolinejad M, Sadeghifard N, Aligholi M, et al. Antimicrobial susceptibility patterns and distribution of blaOXA genes among Acinetobacter spp. Isolated from patients at Tehran hospitals. Jpn J Infect Dis. 2008; 61(4): 274-8[PubMed]
  • 36. Karmostaj A, Peerayeh S, Salmanian A. Emergence of Tigecycline Resistant Acinetobacter baumannii From an Inten-sive Care Unit (ICU) in Tehran. Jundishapur J Microbiol. 2013; 6(3): 215-9
  • 37. Leung E, Weil DE, Raviglione M, Nakatani H, World Health Organization World Health Day Antimicrobial Resistance Technical Working G. The WHO policy package to combat antimicrobial resistance. Bull World Health Organ. 2011; 89(5): 390-2[DOI][PubMed]
  • 38. Kamalbeik S, Talaie H, Mahdavinejad A, Karimi A, Salimi A. Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: is there an association? Korean J Anesthesiol. 2014; 66(4): 295-9[DOI][PubMed]
  • 39. Adams MD, Goglin K, Molyneaux N, Hujer KM, Lavender H, Jamison JJ, et al. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J Bacteriol. 2008; 190(24): 8053-64[DOI][PubMed]
  • 40. Runnegar N, Sidjabat H, Goh HM, Nimmo GR, Schembri MA, Paterson DL. Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a single institution over a 10-year period. J Clin Microbiol. 2010; 48(11): 4051-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments