Jundishapur Journal of Microbiology

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Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection

Hamid Hakimi 1 , Nahid Zainodini 1 , Hossein Khorramdelazad 2 , Mohammad Kazemi Arababadi 1 and Gholamhossein Hassanshahi 2 , *
Authors Information
1 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2 Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
Article information
  • Jundishapur Journal of Microbiology: December 01, 2014, 7 (12); e11152
  • Published Online: December 1, 2014
  • Article Type: Research Article
  • Received: April 9, 2013
  • Revised: July 17, 2013
  • Accepted: July 20, 2013
  • DOI: 10.5812/jjm.11152

To Cite: Hakimi H, Zainodini N, Khorramdelazad H, Kazemi Arababadi M, Hassanshahi G. Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection, Jundishapur J Microbiol. 2014 ; 7(12):e11152. doi: 10.5812/jjm.11152.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Keck C, Gerber-Schafer C, Clad A, Wilhelm C, Breckwoldt M. Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update. 1998; 4(6): 891-903[PubMed]
  • 2. Hamdad-Daoudi F, Petit J, Eb F. Assessment of Chlamydia trachomatis infection in asymptomatic male partners of infertile couples. J Med Microbiol. 2004; 53: 985-90[PubMed]
  • 3. Pawlowska A, Niemiec KT, Filipp E, El Midaoui A, Scholz A, Marianowska S, et al. Chlamydia trachomatis infection in pregnant women hospitalised in the Institute of Mother and Child in Warsaw, Poland. Med Wieku Rozwoj. 2005; 9(1): 21-6[PubMed]
  • 4. Dan M, Samra Z, Siegel YI, Korczak D, Lindner A. Isolation of Chlamydia trachomatis from prostatic tissue of patients undergoing transurethral prostatectomy. Infection. 1991; 19(3): 162-3[PubMed]
  • 5. Al-Mously N, Eley A. Interaction of Chlamydia trachomatis serovar E with male genital tract epithelium results in secretion of proinflammatory cytokines. J Med Microbiol. 2007; 56: 1025-32[DOI][PubMed]
  • 6. Aminzadeh F, Ghorashi Z, Nabati S, Ghasemshirazi M, Arababadi MK, Shamsizadeh A, et al. Differential expression of CXC chemokines CXCL10 and CXCL12 in term and pre-term neonates and their mothers. Am J Reprod Immunol. 2012; 68(4): 338-44[DOI][PubMed]
  • 7. Berlier W, Bourlet T, Levy R, Lucht F, Pozzetto B, Delezay O. Amount of seminal IL-1beta positively correlates to HIV-1 load in the semen of infected patients. J Clin Virol. 2006; 36(3): 204-7[DOI][PubMed]
  • 8. Hanada H, Ikeda-Dantsuji Y, Naito M, Nagayama A. Infection of human fibroblast-like synovial cells with Chlamydia trachomatis results in persistent infection and interleukin-6 production. Microb Pathog. 2003; 34(2): 57-63[PubMed]
  • 9. Derakhshan R, Arababadi MK, Ahmadi Z, Karimabad MN, Salehabadi VA, Abedinzadeh M, et al. Increased circulating levels of SDF-1 (CXCL12) in type 2 diabetic patients are correlated to disease state but are unrelated to polymorphism of the SDF-1beta gene in the Iranian population. Inflammation. 2012; 35(3): 900-4[DOI][PubMed]
  • 10. Zaja-Milatovic S, Richmond A. CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing. Histol Histopathol. 2008; 23(11): 1399-407[PubMed]
  • 11. Mehrad B, Strieter RM. CXC Chemokine Signaling in Interstitial Lung Diseases. Intercellular Signaling in Development and Disease. Cell Signaling colec. 2011; : 441
  • 12. Hassanshahi G, Arababadi MK, Khoramdelazad H, Yaghini N, Zarandi ER. Assessment of CXCL12 (SDF-1alpha) polymorphisms and its serum level in posttransfusion occult HBV-infected patients in Southeastern Iran. Arch Med Res. 2010; 41(5): 338-42[DOI][PubMed]
  • 13. Hassanshahi G, Jafarzadeh A, Ghorashi Z, Zia Sheikholeslami N, Dickson AJ. Expression of IP-10 chemokine is regulated by pro-inflammatory cytokines in cultured hepatocytes. Iran J Allergy Asthma Immunol. 2007; 6(3): 115-21[PubMed]
  • 14. Liang Z, Brooks J, Willard M, Liang K, Yoon Y, Kang S, et al. CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway. Biochem Biophys Res Commun. 2007; 359(3): 716-22[DOI][PubMed]
  • 15. Rottenberg ME, Gigliotti Rothfuchs AC, Gigliotti D, Svanholm C, Bandholtz L, Wigzell H. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol. 1999; 162(5): 2829-36[PubMed]
  • 16. WHO Organization . laboratory manual for the examination of human semen and sperm-cervical mucus interaction 1999;
  • 17. Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nat Rev Immunol. 2010; 10(10): 699-711[DOI][PubMed]
  • 18. Morrison RP, Caldwell HD. Immunity to murine chlamydial genital infection. Infect Immun. 2002; 70(6): 2741-51[PubMed]
  • 19. Mackern Oberti JP, Breser ML, Nunez N, Maccioni M, Rodriguez N, Wantia N, et al. Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells. Reproduction. 2011; 142(3): 427-37[DOI][PubMed]
  • 20. Raman D, Sobolik-Delmaire T, Richmond A. Chemokines in health and disease. Exp Cell Res. 2011; 317(5): 575-89[DOI][PubMed]
  • 21. Trumstedt C, Eriksson E, Lundberg AM, Yang TB, Yan ZQ, Wigzell H, et al. Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae. J Leukoc Biol. 2007; 81(6): 1591-8[DOI][PubMed]
  • 22. Royuela M, de Miguel MP, Ruiz A, Fraile B, Arenas MI, Romo E, et al. Interferon-gamma and its functional receptors overexpression in benign prostatic hyperplasia and prostatic carcinoma: parallelism with c-myc and p53 expression. Eur Cytokine Netw. 2000; 11(1): 119-27[PubMed]
  • 23. Hook CE, Matyszak MK, Gaston JS. Infection of epithelial and dendritic cells by Chlamydia trachomatis results in IL-18 and IL-12 production, leading to interferon-gamma production by human natural killer cells. FEMS Immunol Med Microbiol. 2005; 45(2): 113-20[DOI][PubMed]
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