Mycoses are classified as fungal infections caused by eumycotic organisms such as opportunistic and also pathogenic
Dermatophytes spp., Candida spp., Aspergillus spp., Zygomycetes spp., Feomycetes spp., Cryptococcus and some other fungal species. The frequency of opportunistic, deep and also subcutaneous mycoses compared with both the superficial and cutaneous mycoses amongst the reported cases during the last few decades increased noticeably due to the relation of deep mycoses to underlying conditions such as chemotherapy, radiotherapy, blood and solid organ cancer, hematopoietic system diseases, using a wide spectrum antibiotic, HIV+ and AIDS, endocrine abnormality, organ transplantation and etc ( 1).
Albeit it should be mentioned that among both the superficial and cutaneous mycoses, tinea pedis and tinea unguium increased slightly during the above period. On the contrary, tinea capitis (all three types including ecthotrix, endothrix and favous types), mannum, corporis and cruris showed a notable decreasing tendency but the
Malassezia infection (tinea versicolor) showed no significant change ( 1). According to the reports and records in the last 30 years, the frequency of deep mycoses increased noticeably from ~1.5% to a peak of ~4.7% among suspected cases ( 2).
In fact, ~20% of HIV+ and AIDS patients have been recorded to have an opportunistic fungal infection as one complication. Even now, cases of severe deep mycoses are severely uncontrollable, and their numbers are still increasing (
3, 4). In agreement between clinicians and medical mycologists and according to the published papers on the trends of mycoses, over the past few decades, an increase of deep mycoses (however, the frequency of some deep mycoses decreased slowly), which include aspergillosis, zygomycosis, fusariosis, and non-Candida albicans candidiasis have been observed ( 3, 4) ( Figure 1) .
Figure 1. Causative Agents for Deep Mycoses From the Total 7,960 Cases of Mycoses
Albeit during the same period of time, some certain clinical types of superficial or cutaneous candidiasis have been controlled sufficiently by the use of effective anti-fungal agents such as fluconazole and itraconazole; however, azole-resistant
C. albicans strains and pathogenic non- C. albicans species have been postulated as an important clinical problem. Amongst the reasons for this trend, leukemia was one of the major facts underlying the deep and opportunistic mycoses, followed by solid cancers and other blood and hematopoietic system diseases. Furthermore, acute and chronic systemic aspergillosis has been increasing in bone marrow-transplanted patients (BMT), HIV+, under chemotherapy and radiotherapy and in patients with other immunocompromised conditions ( 2, 4, 5).
These life treated fungal deep infections could be diagnosed and reported as:
1- The direct etiologic agent of death
2- Acute pulmonary mycosis single or both lobes of the lung
3- Acute systemic mycosis of single or more organ systems, including mycoses involving the central nervous system (CNS) (meningitis, encephalitis, meningoencephalitis)
4- Multiorgan systemic infection of more than two or three organ systems
It should also be considered that the available antifungal drugs are limited and antifungal azoles were not efficacious against acute deep mycoses such as acute bronchopulmonary aspergillosis (ABPA) and chronic bronchopulmonary aspergillosis (CBPA). It seems that the background for decrease of some opportunistic mycoses like candidiasis combined with an increase of aspergillosis (ABPA & CBPA) or of other life treated deep mycoses could be listed as:
Using efficacious antifungal azoles worldwide such as fluconazole and itraconazole against severe deep mycoses since 1990.
A prophylactic therapy was usually given to protect immunodeficient patients from the probable acquiring of primary mycoses.
Available antifungal drugs were partially efficacious for severe infections.
Using effective methods for laboratory early detection (PCR, Southern & western blotting, LAMP, Microarray) and also diagnostic techniques for both candidiasis and aspergillosis were inadequate and not yet fully developed.
The number of patients living longer in an immunodeficient situation increased as a result of clinical care developments (
2, 3, 5).
In immunocompromised patients the lung, bronchial system, digestive system, urogenital system and also the skin were most frequently involved regardless of the pathogen species. This suggests that the lung, bronchia, esophagus, mucocutaneous membranes, the vagina and skin are at the highest risk of being exposed to not only exogenous pathogenic fungi, such as
Aspergillus, Cryptococcus, Histoplasma , Dimatiaceous fungi or Zygomycetes, but also endogenous pathogenic fungi, such as Candida species. Although Candida species are usually found commensally in the respiratory tract, digestive tract and vagina and vaginal discharge, it is probable for them to be a basic causative agent of the different types of clinical mycoses in immunodeficient patients. These facts might clarify why the esophagus, mucocutaneous membranes, lung and bronchia are found to be the organs predominantly infected by Candida. Reasonably, Candidal symptoms were also diagnosed more commonly than those of the other major opportunistic fungi in the esophagus, vagina, lung, and bronchi ( 3-5).
In a general perspective, an analysis of the comparison amongst frequency, distribution, epidemiology and incidence of deep mycoses and superficial/cutaneous mycoses, different occupations and leisure-time activities and health statue should be considered as well as the routes of all types of mycoses in different societies. The spreading of this disease in most developed countries of the world represents a considerable health problem, since it is usually accompanied by a parallel increase in the frequency of immunocompromised related diseases. In the other poorer regions of the world, deep mycoses appear primarily due to the poor healthcare systems and their diagnosis. I many cases, treatment often fail caused by the lack of efficient healthcare facilities (