Jundishapur Journal of Microbiology

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Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection

Azam Askari 1 , Gholam Hossein Hassanshahi 2 , Seyed Razi Ghalebi 3 , Abdollah Jafarzadeh 2 , Maryam Mohit 4 , Masomeh Hajghani 2 and Mohammad Kazemi Arababadi 1 , *
Authors Information
1 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2 Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
3 Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
4 Department of Pathology, Kerman University of Medical Sciences, Kerman, IR Iran
Article information
  • Jundishapur Journal of Microbiology: June 01, 2014, 7 (6); e10298
  • Published Online: June 1, 2014
  • Article Type: Research Article
  • Received: February 18, 2013
  • Revised: June 26, 2013
  • Accepted: June 27, 2013
  • DOI: 10.5812/jjm.10298

To Cite: Askari A, Hassanshahi G H, Ghalebi S R, Jafarzadeh A, Mohit M, et al. Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection, Jundishapur J Microbiol. 2014 ; 7(6):e10298. doi: 10.5812/jjm.10298.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Rezvani ME. Association of exon 9 but not intron 8 VDR polymorphisms with occult HBV infection in south-eastern Iranian patients. J Gastroenterol Hepatol. 2010; 25(1): 90-3[DOI][PubMed]
  • 2. Arababadi MK, Hassanshahi G, Yousefi H. HBV-DNA in hemodialysis patients infected by HCV. Saudi J Kidney Dis Transpl. 2009; 20(3): 398-401[PubMed]
  • 3. Azadmanesh K, Mohraz M, Aghakhani A, Edalat R, Jam S, Eslamifar A, et al. Occult hepatitis B virus infection in HIV-infected patients with isolated hepatitis B core antibody. Intervirology. 2008; 51(4): 270-4[DOI][PubMed]
  • 4. Jafarzadeh A, Kazemi Arababadi M, Pourazar M, Mirzaee A. Occult hepatitis B virus infection among blood donors with antibodies to hepatitis B core antigen. Acta Med Iran. 2008; 46(1): 27-32
  • 5. Pourazar A, Salehi M, Jafarzadeh A, Arababadi MK, Oreizi F, Shariatinezhad K. Detection of HBV DNA in HBsAg negative normal blood donors. Iran J Immunol. 2005; 2(3): 172-6
  • 6. Arababadi MK, Hassanshahi G, Pourfathollah AA, Zarandi ER, Kennedy D. Post-transfusion occult hepatitis B (OBI): a global challenge for blood recipients and health authorities. Hepat Mon. 2011; 11(9): 714-8[DOI][PubMed]
  • 7. Ahmadabadi BN, Hassanshahi G, Khoramdelazad H, Mirzaei V, Sajadi SM, Hajghani M, et al. Downregulation of CCR5 expression on the peripheral blood CD8+ T cells of southeastern Iranian patients with chronic hepatitis B infection. Inflammation. 2013; 36(1): 136-40[DOI][PubMed]
  • 8. Arababadi MK, Nasiri Ahmadabadi B, Kennedy D. Current information on the immunologic status of occult hepatitis B infection. Transfusion. 2012; 52(8): 1819-26[DOI][PubMed]
  • 9. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G. Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients. Hepat Mon. 2010; 10(1): 31-5[PubMed]
  • 10. Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM, Noorinayer B, et al. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA. J Clin Virol. 2009; 46(3): 259-64[DOI][PubMed]
  • 11. Bertoletti A, Southwood S, Chesnut R, Sette A, Falco M, Ferrara GB, et al. Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: interaction with HLA and T-cell receptor. Hepatology. 1997; 26(4): 1027-34[DOI][PubMed]
  • 12. Penna A, Chisari FV, Bertoletti A, Missale G, Fowler P, Giuberti T, et al. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med. 1991; 174(6): 1565-70[PubMed]
  • 13. Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Salehi M, Ahmadabadi BN, et al. Hepatitis B virus genotype, HBsAg mutations and co-infection with HCV in occult HBV infection. Clin Res Hepatol Gastroenterol. 2011; 35(8-9): 554-9[DOI][PubMed]
  • 14. Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A. The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy. J Reprod Immunol. 2008; 77(1): 14-22[DOI][PubMed]
  • 15. Hassanshahi G, Jafarzadeh A, Esmaeilzadeh B, Arababadi MK, Yousefi H, Dickson AJ. Assessment of NK cells response to hepatocyte derived chemotactic agents. Pak J Biol Sci. 2008; 11(8): 1120-5[PubMed]
  • 16. Liu HG, Chen WW, Fan ZP, Yang HY, Shi M, Zhang Z, et al. The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope. Clin Immunol. 2007; 125(3): 337-45[DOI][PubMed]
  • 17. Dzhagalov I, Chambon P, He YW. Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma. J Immunol. 2007; 178(4): 2113-21[PubMed]
  • 18. Zhang Y, Li S, Shan M, Pan X, Zhuang K, He L, et al. Hepatitis B virus core antigen epitopes presented by HLA-A2 single-chain trimers induce functional epitope-specific CD8+ T-cell responses in HLA-A2.1/Kb transgenic mice. Immunology. 2007; 121(1): 105-12[DOI][PubMed]
  • 19. Livingston BD, Crimi C, Fikes J, Chesnut RW, Sidney J, Sette A. Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules. Hum Immunol. 1999; 60(11): 1013-7[PubMed]
  • 20. Shi TD, Wu YZ, Jia ZC, Zou LY, Zhou W. Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+ CTL-mediated cytotoxicity in HLA-A2+ human PBMCs. World J Gastroenterol. 2004; 10(13): 1902-6[PubMed]
  • 21. Nayersina R, Fowler P, Guilhot S, Missale G, Cerny A, Schlicht HJ, et al. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol. 1993; 150(10): 4659-71[PubMed]
  • 22. Yao YL. [Determination of circulating HBV specific CD8+ T cells in hepatitis B patients by flow cytometry and its clinical significance]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010; 24(6): 476-8[PubMed]
  • 23. Gu XB, Yang XJ, Wang JH, Hua Z, Lu ZH, Xu YQ, et al. [Relationship between viral genotype and specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011; 25(3): 211-3[PubMed]
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