Jundishapur Journal of Microbiology

Published by: Kowsar

Nosocomial Outbreak of Extensively and Pan Drug-Resistant Acinetobacter baumannii in Tertiary Hospital in Central Part of Iran

Alireza Japoni-Nejad 1 , 2 , Masoomeh Sofian 3 , 4 , Alex van Belkum 5 , 6 and Ehsanollah Ghaznavi-Rad 2 , 7 , *
Authors Information
1 Student Research Committee, Arak University of Medical Sciences, Arak, IR Iran
2 Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR Iran
3 Department of Infectious Disease, Arak University of Medical Sciences, Arak, IR Iran
4 Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, IR Iran
5 Department of Medical Microbiology and Infectious Diseases Erasmus MC,Rotterdam, The Netherlands
6 Unit Microbiology, R&D Microbiology, BioMerieux, France
7 Molecular and Medicine Research Center, Department of Microbiology, School of Medicine, Arak University of Medical Sciences, Arak, IR Iran
Article information
  • Jundishapur Journal of Microbiology: October 01, 2013, 6 (8); e9892
  • Published Online: October 1, 2013
  • Article Type: Research Article
  • Received: December 26, 2012
  • Revised: February 20, 2013
  • Accepted: March 10, 2013
  • DOI: 10.5812/jjm.9892

To Cite: Japoni-Nejad A, Sofian M, Belkum A V, Ghaznavi-Rad E. Nosocomial Outbreak of Extensively and Pan Drug-Resistant Acinetobacter baumannii in Tertiary Hospital in Central Part of Iran, Jundishapur J Microbiol. 2013 ; 6(8):e9892. doi: 10.5812/jjm.9892.

Copyright © 2013, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Ruiz M, Marti S, Fernandez-Cuenca F, Pascual A, Vila J. Prevalence of IS(Aba1) in epidemiologically unrelated Acinetobacter baumannii clinical isolates. FEMS Microbiol Lett. 2007; 274(1): 63-6[DOI][PubMed]
  • 2. Richet Hervé, Pierre Edouard Fournier MD. Nosocomial infections caused by Acinetobacter baumannii: a major threat worldwide. Infect Cont Hosp Epidemiol. 2006; 27(7): 645-646
  • 3. Lin YC, Sheng WH, Chen YC, Chang SC, Hsia KC, Li SY. Differences in carbapenem resistance genes among Acinetobacterbaumannii, Acinetobacter genospecies 3 and Acinetobacter genospecies 13TU in Taiwan. Int J Antimicrob Agents. 2010; 35(5): 439-43[DOI][PubMed]
  • 4. Falagas ME, Karageorgopoulos DE. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin Infect Dis. 2008; 46(7): 1121-2[DOI][PubMed]
  • 5. Lin L, Ling BD, Li XZ. Distribution of the multidrug efflux pump genes, adeABC, adeDE and adeIJK, and class 1 integron genes in multiple-antimicrobial-resistant clinical isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus complex. Int J Antimicrob Agents. 2009; 33(1): 27-32[DOI][PubMed]
  • 6. Woodford N, Ellington MJ, Coelho JM, Turton JF, Ward ME, Brown S, et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents. 2006; 27(4): 351-3[DOI][PubMed]
  • 7. Gales AC, Reis AO, Jones RN. Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: review of available interpretative criteria and quality control guidelines. J Clin Microbiol. 2001; 39(1): 183-90[DOI][PubMed]
  • 8. Clinical Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing, twenty first informational supplement M100-S21. 2011;
  • 9. Segal H, Elisha BG. Use of Etest MBL strips for the detection of carbapenemases in Acinetobacter baumannii. J Antimicrob Chemother. 2005; 56(3): 598[DOI][PubMed]
  • 10. Hanson ND. AmpC beta-lactamases: what do we need to know for the future? J Antimicrob Chemother. 2003; 52(1): 2-4[DOI][PubMed]
  • 11. Noyal MJ, Menezes GA, Harish BN, Sujatha S, Parija SC. Simple screening tests for detection of carbapenemases in clinical isolates of nonfermentative Gram-negative bacteria. Indian J Med Res. 2009; 129(6): 707-12[PubMed]
  • 12. Brink AJ, Bizos D, Boffard KD, Feldman C, Grolman DC, Pretorius J, et al. Guideline: appropriate use of tigecycline. S Afr Med J. 2010; 100(6 Pt 2): 388-94[PubMed]
  • 13. Li J, Rayner CR, Nation RL, Owen RJ, Spelman D, Tan KE, et al. Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2006; 50(9): 2946-50[DOI][PubMed]
  • 14. Fernandez Cuenca F, Sanchez Mdel C, Caballero-Moyano FJ, Vila J, Martinez-Martinez L, Bou G, et al. Prevalence and analysis of microbiological factors associated with phenotypic heterogeneous resistance to carbapenems in Acinetobacter baumannii. Int J Antimicrob Agents. 2012; 39(6): 472-7[DOI][PubMed]
  • 15. Al Johani SM, Akhter J, Balkhy H, El-Saed A, Younan M, Memish Z. Prevalence of antimicrobial resistance among gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia. Ann Saudi Med. 2010; 30(5): 364-9[DOI][PubMed]
  • 16. Feizabadi MM, Fathollahzadeh B, Taherikalani M, Rasoolinejad M, Sadeghifard N, Aligholi M, et al. Antimicrobial susceptibility patterns and distribution of blaOXA genes among Acinetobacter spp. Isolated from patients at Tehran hospitals. Jpn J Infect Dis. 2008; 61(4): 274-8[PubMed]
  • 17. Hamzeh AR, Al Najjar M, Mahfoud M. Prevalence of antibiotic resistance among Acinetobacter baumannii isolates from Aleppo, Syria. Am J Infect Control. 2012; 40(8): 776-7[DOI][PubMed]
  • 18. Maragakis LL, Perl TM. Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. Clin Infect Dis. 2008; 46(8): 1254-63[DOI][PubMed]
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