Jundishapur Journal of Microbiology

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Prevalence of Quinolone Resistance Genes Among Extended-Spectrum B-Lactamase-Producing Escherichia coli in Mashhad, Iran

Elnaz Harifi Mood 1 , 2 , Zahra Meshkat 2 , Nafiseh Izadi 1 , 2 , Maryam Rezaei 3 , Saeid Amel Jamehdar 2 and Mahboubeh Naderi Nasab 2 , *
Authors Information
1 Student Research Committee (SRC), Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran
Article information
  • Jundishapur Journal of Microbiology: December 01, 2015, 8 (12); e16217
  • Published Online: December 7, 2015
  • Article Type: Research Article
  • Received: November 16, 2013
  • Revised: April 13, 2015
  • Accepted: May 6, 2015
  • DOI: 10.5812/jjm.16217

To Cite: Harifi Mood E, Meshkat Z, Izadi N, Rezaei M, Amel Jamehdar S, et al. Prevalence of Quinolone Resistance Genes Among Extended-Spectrum B-Lactamase-Producing Escherichia coli in Mashhad, Iran, Jundishapur J Microbiol. 2015 ; 8(12):e16217. doi: 10.5812/jjm.16217.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Takahashi H, Hayakawa I, Akimoto T. [The history of the development and changes of quinolone antibacterial agents]. Yakushigaku Zasshi. 2003; 38(2): 161-79[PubMed]
  • 2. Robicsek A, Jacoby GA, Hooper DC. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis. 2006; 6(10): 629-40[DOI][PubMed]
  • 3. Martinez-Martinez L, Pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid. Lancet. 1998; 351(9105): 797-9[DOI][PubMed]
  • 4. Stavoe AKH. Plasmid-mediated quinolone and fluoroquinolone resistance. MMG445 Basic Biotech J. 2006; 2(1): 154-9
  • 5. Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Park CH, et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med. 2006; 12(1): 83-8[DOI][PubMed]
  • 6. Ma J, Zeng Z, Chen Z, Xu X, Wang X, Deng Y, et al. High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob Agents Chemother. 2009; 53(2): 519-24[DOI][PubMed]
  • 7. Tran JH, Jacoby GA. Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci U S A. 2002; 99(8): 5638-42[DOI][PubMed]
  • 8. Behrooozi A, Rahbar M, Yousefi JV. Frequency of extended spectrum beta-lactamase (ESBLs) producing Escherichia coli and klebseilla pneumonia isolated from urine in an Iranian 1000-bed tertiary care hospital. Afr J Microbiol Res. 2010; 4(9): 881-4
  • 9. Rupp ME, Fey PD. Extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae: considerations for diagnosis, prevention and drug treatment. Drugs. 2003; 63(4): 353-65[PubMed]
  • 10. Pakzad I, Ghafourian S, Taherikalani M, Sadeghifard N, Abtahi H, Rahbar M, et al. qnr Prevalence in Extended Spectrum Beta-lactamases (ESBLs) and None-ESBLs Producing Escherichia coli Isolated from Urinary Tract Infections in Central of Iran. Iran J Basic Med Sci. 2011; 14(5): 458-64[PubMed]
  • 11. Cerquetti M, Garcia-Fernandez A, Giufre M, Fortini D, Accogli M, Graziani C, et al. First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. Antimicrob Agents Chemother. 2009; 53(7): 3112-4[DOI][PubMed]
  • 12. Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob Agents Chemother. 2006; 50(8): 2872-4[DOI][PubMed]
  • 13. Kim MH, Lee HJ, Park KS, Suh JT. Molecular characteristics of extended spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae and the prevalence of qnr in Extended spectrum beta-lactamase isolates in a tertiary care hospital in Korea. Yonsei Med J. 2010; 51(5): 768-74[DOI][PubMed]
  • 14. Pai H, Seo MR, Choi TY. Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2007; 51(1): 366-8[DOI][PubMed]
  • 15. Nordmann P, Poirel L. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J Antimicrob Chemother. 2005; 56(3): 463-9[DOI][PubMed]
  • 16. Poirel L, Cattoir V, Soares A, Soussy CJ, Nordmann P. Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. Antimicrob Agents Chemother. 2007; 51(2): 631-7[DOI][PubMed]
  • 17. Centers for Medicare , Medicaid Services . Are You a Hospital Inpatient Or Outpatient?: If You Have Medicare--ask! 2009; : 1-8
  • 18. Hajian-Tilaki K. Sample size estimation in epidemiologic studies. Caspian J Intern Med. 2011; 2(4): 289-98[PubMed]
  • 19. Textbook of Diagnostic Microbiology 2014;
  • 20. Wikler MA. Performance standards for antimicrobial susceptibility testing: Sixteenth informational supplement. 2012;
  • 21. Zaniani FR, Meshkat Z, Naderi Nasab M, Khaje-Karamadini M, Ghazvini K, Rezaee A, et al. The Prevalence of TEM and SHV Genes among Extended-Spectrum Beta-Lactamases Producing Escherichia Coli and Klebsiella Pneumoniae Iran J Basic Med Sci. 2012; 15(1): 654-60[PubMed]
  • 22. Cheung TK, Chu YW, Chu MY, Ma CH, Yung RW, Kam KM. Plasmid-mediated resistance to ciprofloxacin and cefotaxime in clinical isolates of Salmonella enterica serotype Enteritidis in Hong Kong. J Antimicrob Chemother. 2005; 56(3): 586-9[DOI][PubMed]
  • 23. Latifi-Navid S, Ghorashi SA, Siavoshi F, Linz B, Massarrat S, Khegay T, et al. Ethnic and geographic differentiation of Helicobacter pylori within Iran. PLoS One. 2010; 5(3)[DOI][PubMed]
  • 24. Bazzaz BS, Naderinasab M, Mohamadpoor AH, Farshadzadeh Z, Ahmadi S, Yousefi F. The prevalence of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae among clinical isolates from a general hospital in Iran. Acta Microbiol Immunol Hung. 2009; 56(1): 89-99[DOI][PubMed]
  • 25. Masjedian Jazi F, Valehi F, Talebi A, RastegarLari A. Molecular characterization of resistance to Extended -Spectrum antibiotics in Escherichia coli and Klebsiellapneumoniae. Iran J Med Microbiol. 2007; 2: 27-34
  • 26. Khorshidi A, Rohani M, Moniri R. The prevalence and molecular characterization of extended-spectrum β-lactamases-producing Klebsiella pneumoniae isolates recovered from Kashan hospital university, Iran. Jundishapur J Microbiol. 2011; 4(4): 289-94
  • 27. Hassan WM, Hashim A, Domany R. Plasmid mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qep in ESBL-producing Escherichia coli clinical isolates from Egypt. Indian J Med Microbiol. 2012; 30(4): 442-7[DOI][PubMed]
  • 28. Bouchakour M, Zerouali K, Gros Claude JD, Amarouch H, El Mdaghri N, Courvalin P, et al. Plasmid-mediated quinolone resistance in expanded spectrum beta lactamase producing enterobacteriaceae in Morocco. J Infect Dev Ctries. 2010; 4(12): 779-803[PubMed]
  • 29. Cattoir V, Poirel L, Rotimi V, Soussy CJ, Nordmann P. Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother. 2007; 60(2): 394-7[DOI][PubMed]
  • 30. Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, et al. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother. 2006; 50(4): 1178-82[DOI][PubMed]
  • 31. Jeong HS, Bae IK, Shin JH, Jung HJ, Kim SH, Lee JY, et al. Prevalence of plasmid-mediated quinolone resistance and its association with extended-spectrum beta-lactamase and AmpC beta-lactamase in Enterobacteriaceae. Korean J Lab Med. 2011; 31(4): 257-64[DOI][PubMed]
  • 32. Wu JJ, Ko WC, Tsai SH, Yan JJ. Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. Antimicrob Agents Chemother. 2007; 51(4): 1223-7[DOI][PubMed]
  • 33. Allou N, Cambau E, Massias L, Chau F, Fantin B. Impact of low-level resistance to fluoroquinolones due to qnrA1 and qnrS1 genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of Escherichia coli urinary tract infection. Antimicrob Agents Chemother. 2009; 53(10): 4292-7[DOI][PubMed]
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