Jundishapur Journal of Microbiology

Published by: Kowsar

A Novel Reduction Strategy of Clarithromycin Resistance in Helicobacter pylori

Omid Tadjrobehkar 1 , 2 and Hamid Abdollahi 1 , *
Authors Information
1 Department of Microbiology, Medical School, Kerman University of Medical Sciences, Kerman, IR Iran
2 School of Medicine, Zabol University of Medical Sciences, Zabol, Zahedan, IR Iran
Article information
  • Jundishapur Journal of Microbiology: December 01, 2014, 7 (12); e13081
  • Published Online: December 1, 2014
  • Article Type: Research Article
  • Received: June 22, 2013
  • Revised: September 9, 2013
  • Accepted: September 11, 2013
  • DOI: 10.5812/jjm.13081

To Cite: Tadjrobehkar O, Abdollahi H. A Novel Reduction Strategy of Clarithromycin Resistance in Helicobacter pylori, Jundishapur J Microbiol. 2014 ; 7(12):e13081. doi: 10.5812/jjm.13081.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983; 1(8336): 1273-5[PubMed]
  • 2. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985; 142(8): 436-9[PubMed]
  • 3. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut. 2012; 61(5): 646-64[DOI][PubMed]
  • 4. McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med. 2010; 362(17): 1597-604[DOI][PubMed]
  • 5. Wu W, Yang Y, Sun G. Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication. Gastroenterol Res Pract. 2012; 2012: 723183[DOI][PubMed]
  • 6. Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest. 2009; 119(9): 2475-87[DOI][PubMed]
  • 7. de Reuse H, Bereswill S. Ten years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen. FEMS Immunol Med Microbiol. 2007; 50(2): 165-76[DOI][PubMed]
  • 8. Kraft C, Suerbaum S. Mutation and recombination in Helicobacter pylori: mechanisms and role in generating strain diversity. Int J Med Microbiol. 2005; 295(5): 299-305[DOI][PubMed]
  • 9. Cirz RT, Chin JK, Andes DR, de Crecy-Lagard V, Craig WA, Romesberg FE. Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS Biol. 2005; 3(6)[DOI][PubMed]
  • 10. Abdollahi H, Tadjrobehkar O. The role of different sugars, amino acids and few other substances in chemotaxis directed motility of helicobacter pylori. Iran J Basic Med Sci. 2012; 15(3): 787-94[PubMed]
  • 11. Bjorkholm B, Sjolund M, Falk PG, Berg OG, Engstrand L, Andersson DI. Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori. Proc Natl Acad Sci U S A. 2001; 98(25): 14607-12[DOI][PubMed]
  • 12. Rosche WA, Foster PL. Determining mutation rates in bacterial populations. Methods. 2000; 20(1): 4-17[DOI][PubMed]
  • 13. Wang G, Wilson TJ, Jiang Q, Taylor DE. Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori. Antimicrob Agents Chemother. 2001; 45(3): 727-33[DOI][PubMed]
  • 14. Taylor DE, Ge Z, Purych D, Lo T, Hiratsuka K. Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. Antimicrob Agents Chemother. 1997; 41(12): 2621-8[PubMed]
  • 15. De Francesco V, Giorgio F, Hassan C, Manes G, Vannella L, Panella C, et al. Worldwide H. pylori antibiotic resistance: a systematic review. J Gastrointestin Liver Dis. 2010; 19(4): 409-14[PubMed]
  • 16. Megraud F, Coenen S, Versporten A, Kist M, Lopez-Brea M, Hirschl AM, et al. Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut. 2013; 62(1): 34-42[DOI][PubMed]
  • 17. Versalovic J, Shortridge D, Kibler K, Griffy MV, Beyer J, Flamm RK, et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob Agents Chemother. 1996; 40(2): 477-80[PubMed]
  • 18. Kumar RV, Venkatrajireddy G, Bikshapathi T, Reddy MK. Antioxidant-the maximum expressed activity among 63 medicinal plants. J Phyto Pharmacol. 2012; 1(5): 1-13
  • 19. Milosevic-Djordjevic O, Stosic I, Stankovic M, Grujicic D. Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay. Cytotechnology. 2013; 65(5): 863-9[DOI][PubMed]
  • 20. Sibanda T, Okoh AI. The challenges of overcoming antibiotic resistance: Plant extracts as potential sources of antimicrobial and resistance modifying agents. Afr J Biotechnol. 2007; 6(25): 2886-96
  • 21. Andersson DI. The biological cost of mutational antibiotic resistance: any practical conclusions? Curr Opin Microbiol. 2006; 9(5): 461-5[DOI][PubMed]
  • 22. De Francesco V, Zullo A, Ierardi E, Giorgio F, Perna F, Hassan C, et al. Phenotypic and genotypic Helicobacter pylori clarithromycin resistance and therapeutic outcome: benefits and limits. J Antimicrob Chemother. 2010; 65(2): 327-32[DOI][PubMed]
  • 23. Wei A, Shibamoto T. Antioxidant/lipoxygenase inhibitory activities and chemical compositions of selected essential oils. J Agric Food Chem. 2010; 58(12): 7218-25[DOI][PubMed]
  • 24. Aidi Wannes W, Mhamdi B, Sriti J, Ben Jemia M, Ouchikh O, Hamdaoui G, et al. Antioxidant activities of the essential oils and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower. Food Chem Toxicol. 2010; 48(5): 1362-70[DOI][PubMed]
  • 25. Hayder N, Abdelwahed A, Kilani S, Ammar RB, Mahmoud A, Ghedira K, et al. Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis. Mutat Res. 2004; 564(1): 89-95[DOI][PubMed]
  • 26. Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005; 19(11): 988-91[DOI][PubMed]
  • 27. Meena AK, Bansal P, Kumar S. Plants-herbal wealth as a potential source of ayurvedic drugs. Asian J Tradi Med. 2009; 4(4): 152-70
  • 28. Miguel MG. Antioxidant and anti-inflammatory activities of essential oils: a short review. Molecules. 2010; 15(12): 9252-87[DOI][PubMed]
  • 29. Wojdylo A, Oszmianski J, Czemerys R. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 2007; 105(3): 940-9[DOI]
  • 30. Zaidi SF, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W, et al. Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J Ethnopharmacol. 2012; 141(1): 403-10[DOI][PubMed]
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