Jundishapur Journal of Microbiology

Published by: Kowsar

Toxoplasma gondii Exposure and the Risk of Schizophrenia

Shahram Khademvatan 1 , Jasem Saki 2 , * , Niloufar Khajeddin 3 , Maryam Izadi-Mazidi 4 , Reza Beladi 3 , Behnaz Shafiee 3 and Zahra Salehi 2
Authors Information
1 Department of Parasitology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR Iran
2 Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Psychiatry, Golestan Educational Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
4 Clinical Psychology Departent, Shahed University, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: November 01, 2014, 7 (11); e18789
  • Published Online: November 1, 2014
  • Article Type: Research Article
  • Received: October 1, 2013
  • Revised: November 2, 2013
  • Accepted: March 28, 2014
  • DOI: 10.5812/jjm.18789

To Cite: Khademvatan S, Saki J, Khajeddin N, Izadi-Mazidi M, Beladi R, et al. Toxoplasma gondii Exposure and the Risk of Schizophrenia, Jundishapur J Microbiol. 2014 ; 7(11):e18789. doi: 10.5812/jjm.18789.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Sadock BJ, Kaplan HI, Sadock VA. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. 2007;
  • 2. Sadock BJ, Sadock VA, Ruiz P, Kaplan HI. Kaplan and Sadock's Comprehensive Textbook of Psychiatry. 2009;
  • 3. Fittipaldi KE. Toxoplasma gondii as an etiological agent of schizophrenia. 2008;
  • 4. Freedman R. Schizophrenia. N Engl J Med. 2003; 349(18): 1738-49[DOI][PubMed]
  • 5. Mahmoud SS, Hasan MS. Seroprevalence of toxoplasmosis among schizophrenic patients. Yemeni J Med Sci. 2009; 1(3): 1-7
  • 6. Yuksel P, Kocazeybek B, Alpay N, Babur C, Bayar R, Karaköse AR, et al. Establishing the Role of Latent Toxoplasmosis in the Ethiopathogenesis of Schizophrenia. Int J Infect Dis. 2008; 12
  • 7. Niebuhr DW, Millikan AM, Cowan DN, Yolken R, Li Y, Weber NS. Selected infectious agents and risk of schizophrenia among U.S. military personnel. Am J Psychiatry. 2008; 165(1): 99-106[DOI][PubMed]
  • 8. Hinze-Selch D, Daubener W, Eggert L, Erdag S, Stoltenberg R, Wilms S. A controlled prospective study of toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence. Schizophr Bull. 2007; 33(3): 782-8[DOI][PubMed]
  • 9. Mortensen PB, Norgaard-Pedersen B, Waltoft BL, Sorensen TL, Hougaard D, Torrey EF, et al. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol Psychiatry. 2007; 61(5): 688-93[DOI][PubMed]
  • 10. Cetinkaya Z, Yazar S, Gecici O, Namli MN. Anti-Toxoplasma gondii antibodies in patients with schizophrenia--preliminary findings in a Turkish sample. Schizophr Bull. 2007; 33(3): 789-91[DOI][PubMed]
  • 11. Brown AS, Schaefer CA, Quesenberry CP, Jr, Liu L, Babulas VP, Susser ES. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005; 162(4): 767-73[DOI][PubMed]
  • 12. Suzuki Y. Host resistance in the brain against Toxoplasma gondii. J Infect Dis. 2002; 185 Suppl 1-65[DOI][PubMed]
  • 13. Dubey JP. Toxoplasma gondii infections in chickens (Gallus domesticus): prevalence, clinical disease, diagnosis and public health significance. Zoonoses Public Health. 2010; 57(1): 60-73[DOI][PubMed]
  • 14. Kijlstra A, Jongert E. Control of the risk of human toxoplasmosis transmitted by meat. Int J Parasitol. 2008; 38(12): 1359-70[DOI][PubMed]
  • 15. Herrmann DC, Pantchev N, Vrhovec MG, Barutzki D, Wilking H, Frohlich A, et al. Atypical Toxoplasma gondii genotypes identified in oocysts shed by cats in Germany. Int J Parasitol. 2010; 40(3): 285-92[DOI][PubMed]
  • 16. Dubey JP, Jones JL. Toxoplasma gondii infection in humans and animals in the United States. Int J Parasitol. 2008; 38(11): 1257-78[DOI][PubMed]
  • 17. Miller CM, Boulter NR, Ikin RJ, Smith NC. The immunobiology of the innate response to Toxoplasma gondii. Int J Parasitol. 2009; 39(1): 23-39[DOI][PubMed]
  • 18. Flegr J, Zitkova S, Kodym P, Frynta D. Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology. 1996; 113 ( Pt 1): 49-54[PubMed]
  • 19. Flegr J, Havlicek J. Changes in the personality profile of young women with latent toxoplasmosis. Folia Parasitol (Praha). 1999; 46(1): 22-8[PubMed]
  • 20. Flegr J, Kodym P, Tolarova V. Correlation of duration of latent Toxoplasma gondii infection with personality changes in women. Biol Psychol. 2000; 53(1): 57-68[PubMed]
  • 21. Falagas ME, Rizos M, Bliziotis IA, Rellos K, Kasiakou SK, Michalopoulos A. Toxicity after prolonged (more than four weeks) administration of intravenous colistin. BMC Infect Dis. 2005; 5: 1[DOI][PubMed]
  • 22. Khademvatan S, Khajeddin N, Saki J, Izadi-Mazidi S. Effect of toxoplasmosis on personality profiles of Iranian men and women. S Afr J Sci. 2013; 109(1-2): 1-4
  • 23. Hamidinejat H, Ghorbanpoor M, Hosseini H, Alavi SM, Nabavi L, Jalali MH, et al. Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia. Int J Infect Dis. 2010; 14(11)-81[DOI][PubMed]
  • 24. Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS One. 2011; 6(9)[DOI][PubMed]
  • 25. Webster JP. The effect of Toxoplasma gondii on animal behavior: playing cat and mouse. Schizophr Bull. 2007; 33(3): 752-6[DOI][PubMed]
  • 26. Torrey EF, Yolken RH. Toxoplasma gondii and schizophrenia. Emerg Infect Dis. 2003; 9(11): 1375-80[DOI][PubMed]
  • 27. Fuller Torrey E, Rawlings R, Yolken RH. The antecedents of psychoses: a case-control study of selected risk factors. Schizophr Res. 2000; 46(1): 17-23[PubMed]
  • 28. Webster JP, Lamberton PH, Donnelly CA, Torrey EF. Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviour. Proc Biol Sci. 2006; 273(1589): 1023-30[DOI][PubMed]
  • 29. Saraei-Sahnesaraei M, Shamloo F, Jahani Hashemi H, Khabbaz F, Alizadeh S. Relation between Toxoplasma gondii infections and schizophrenia. IJPCP. 2009; 15(1): 3-9
  • 30. Xiao Y, Yin J, Jiang N, Xiang M, Hao L, Lu H, et al. Seroepidemiology of human Toxoplasma gondii infection in China. BMC Infect Dis. 2010; 10: 4[DOI][PubMed]
  • 31. Saeedi M, Veghari GR, Marjani A. Seroepidemiologic evaluation of anti-toxoplasma antibodies among women in north of Iran. Pak J Biol Sci. 2007; 10(14): 2359-62[PubMed]
  • 32. Ahmad MS, Maqbool A, Mahmood-ul-Hassan M, Mushtaq-ul-Hassan M, Anjum AA. Prevalence of toxoplasma gondii antibodies in human beings and commensal rodents trapped from Lahore, Pakistan. J Anim Plant Sci. 2012; 22: 51-3
  • 33. Roberts CW, Cruickshank SM, Alexander J. Sex-determined resistance to Toxoplasma gondii is associated with temporal differences in cytokine production. Infect Immun. 1995; 63(7): 2549-55[PubMed]
  • 34. Jones-Brando L, Torrey EF, Yolken R. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 2003; 62(3): 237-44[PubMed]
  • 35. Darde ML. Genetic analysis of the diversity in Toxoplasma gondii. Ann Ist Super Sanita. 2004; 40(1): 57-63[PubMed]
  • 36. Kolbekova P, Kourbatova E, Novotna M, Kodym P, Flegr J. New and old risk-factors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech Republic. Clin Microbiol Infect. 2007; 13(10): 1012-7[DOI][PubMed]
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