Jundishapur Journal of Microbiology

Published by: Kowsar

Toxoplasma gondii Exposure and the Risk of Schizophrenia

Shahram Khademvatan 1 , Jasem Saki 2 , * , Niloufar Khajeddin 3 , Maryam Izadi-Mazidi 4 , Reza Beladi 3 , Behnaz Shafiee 3 and Zahra Salehi 2
Authors Information
1 Department of Parasitology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR Iran
2 Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Psychiatry, Golestan Educational Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
4 Clinical Psychology Departent, Shahed University, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: November 01, 2014, 7 (11); e18789
  • Published Online: November 1, 2014
  • Article Type: Research Article
  • Received: October 1, 2013
  • Revised: November 2, 2013
  • Accepted: March 28, 2014
  • DOI: 10.5812/jjm.18789

To Cite: Khademvatan S, Saki J, Khajeddin N, Izadi-Mazidi M, Beladi R, et al. Toxoplasma gondii Exposure and the Risk of Schizophrenia, Jundishapur J Microbiol. 2014 ; 7(11):e18789. doi: 10.5812/jjm.18789.

Abstract
Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Sadock BJ, Kaplan HI, Sadock VA. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. 2007;
  • 2. Sadock BJ, Sadock VA, Ruiz P, Kaplan HI. Kaplan and Sadock's Comprehensive Textbook of Psychiatry. 2009;
  • 3. Fittipaldi KE. Toxoplasma gondii as an etiological agent of schizophrenia. 2008;
  • 4. Freedman R. Schizophrenia. N Engl J Med. 2003; 349(18): 1738-49[DOI][PubMed]
  • 5. Mahmoud SS, Hasan MS. Seroprevalence of toxoplasmosis among schizophrenic patients. Yemeni J Med Sci. 2009; 1(3): 1-7
  • 6. Yuksel P, Kocazeybek B, Alpay N, Babur C, Bayar R, Karaköse AR, et al. Establishing the Role of Latent Toxoplasmosis in the Ethiopathogenesis of Schizophrenia. Int J Infect Dis. 2008; 12
  • 7. Niebuhr DW, Millikan AM, Cowan DN, Yolken R, Li Y, Weber NS. Selected infectious agents and risk of schizophrenia among U.S. military personnel. Am J Psychiatry. 2008; 165(1): 99-106[DOI][PubMed]
  • 8. Hinze-Selch D, Daubener W, Eggert L, Erdag S, Stoltenberg R, Wilms S. A controlled prospective study of toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence. Schizophr Bull. 2007; 33(3): 782-8[DOI][PubMed]
  • 9. Mortensen PB, Norgaard-Pedersen B, Waltoft BL, Sorensen TL, Hougaard D, Torrey EF, et al. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol Psychiatry. 2007; 61(5): 688-93[DOI][PubMed]
  • 10. Cetinkaya Z, Yazar S, Gecici O, Namli MN. Anti-Toxoplasma gondii antibodies in patients with schizophrenia--preliminary findings in a Turkish sample. Schizophr Bull. 2007; 33(3): 789-91[DOI][PubMed]
  • 11. Brown AS, Schaefer CA, Quesenberry CP, Jr, Liu L, Babulas VP, Susser ES. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005; 162(4): 767-73[DOI][PubMed]
  • 12. Suzuki Y. Host resistance in the brain against Toxoplasma gondii. J Infect Dis. 2002; 185 Suppl 1-65[DOI][PubMed]
  • 13. Dubey JP. Toxoplasma gondii infections in chickens (Gallus domesticus): prevalence, clinical disease, diagnosis and public health significance. Zoonoses Public Health. 2010; 57(1): 60-73[DOI][PubMed]
  • 14. Kijlstra A, Jongert E. Control of the risk of human toxoplasmosis transmitted by meat. Int J Parasitol. 2008; 38(12): 1359-70[DOI][PubMed]
  • 15. Herrmann DC, Pantchev N, Vrhovec MG, Barutzki D, Wilking H, Frohlich A, et al. Atypical Toxoplasma gondii genotypes identified in oocysts shed by cats in Germany. Int J Parasitol. 2010; 40(3): 285-92[DOI][PubMed]
  • 16. Dubey JP, Jones JL. Toxoplasma gondii infection in humans and animals in the United States. Int J Parasitol. 2008; 38(11): 1257-78[DOI][PubMed]
  • 17. Miller CM, Boulter NR, Ikin RJ, Smith NC. The immunobiology of the innate response to Toxoplasma gondii. Int J Parasitol. 2009; 39(1): 23-39[DOI][PubMed]
  • 18. Flegr J, Zitkova S, Kodym P, Frynta D. Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology. 1996; 113 ( Pt 1): 49-54[PubMed]
  • 19. Flegr J, Havlicek J. Changes in the personality profile of young women with latent toxoplasmosis. Folia Parasitol (Praha). 1999; 46(1): 22-8[PubMed]
  • 20. Flegr J, Kodym P, Tolarova V. Correlation of duration of latent Toxoplasma gondii infection with personality changes in women. Biol Psychol. 2000; 53(1): 57-68[PubMed]
  • 21. Falagas ME, Rizos M, Bliziotis IA, Rellos K, Kasiakou SK, Michalopoulos A. Toxicity after prolonged (more than four weeks) administration of intravenous colistin. BMC Infect Dis. 2005; 5: 1[DOI][PubMed]
  • 22. Khademvatan S, Khajeddin N, Saki J, Izadi-Mazidi S. Effect of toxoplasmosis on personality profiles of Iranian men and women. S Afr J Sci. 2013; 109(1-2): 1-4
  • 23. Hamidinejat H, Ghorbanpoor M, Hosseini H, Alavi SM, Nabavi L, Jalali MH, et al. Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia. Int J Infect Dis. 2010; 14(11)-81[DOI][PubMed]
  • 24. Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS One. 2011; 6(9)[DOI][PubMed]
  • 25. Webster JP. The effect of Toxoplasma gondii on animal behavior: playing cat and mouse. Schizophr Bull. 2007; 33(3): 752-6[DOI][PubMed]
  • 26. Torrey EF, Yolken RH. Toxoplasma gondii and schizophrenia. Emerg Infect Dis. 2003; 9(11): 1375-80[DOI][PubMed]
  • 27. Fuller Torrey E, Rawlings R, Yolken RH. The antecedents of psychoses: a case-control study of selected risk factors. Schizophr Res. 2000; 46(1): 17-23[PubMed]
  • 28. Webster JP, Lamberton PH, Donnelly CA, Torrey EF. Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviour. Proc Biol Sci. 2006; 273(1589): 1023-30[DOI][PubMed]
  • 29. Saraei-Sahnesaraei M, Shamloo F, Jahani Hashemi H, Khabbaz F, Alizadeh S. Relation between Toxoplasma gondii infections and schizophrenia. IJPCP. 2009; 15(1): 3-9
  • 30. Xiao Y, Yin J, Jiang N, Xiang M, Hao L, Lu H, et al. Seroepidemiology of human Toxoplasma gondii infection in China. BMC Infect Dis. 2010; 10: 4[DOI][PubMed]
  • 31. Saeedi M, Veghari GR, Marjani A. Seroepidemiologic evaluation of anti-toxoplasma antibodies among women in north of Iran. Pak J Biol Sci. 2007; 10(14): 2359-62[PubMed]
  • 32. Ahmad MS, Maqbool A, Mahmood-ul-Hassan M, Mushtaq-ul-Hassan M, Anjum AA. Prevalence of toxoplasma gondii antibodies in human beings and commensal rodents trapped from Lahore, Pakistan. J Anim Plant Sci. 2012; 22: 51-3
  • 33. Roberts CW, Cruickshank SM, Alexander J. Sex-determined resistance to Toxoplasma gondii is associated with temporal differences in cytokine production. Infect Immun. 1995; 63(7): 2549-55[PubMed]
  • 34. Jones-Brando L, Torrey EF, Yolken R. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 2003; 62(3): 237-44[PubMed]
  • 35. Darde ML. Genetic analysis of the diversity in Toxoplasma gondii. Ann Ist Super Sanita. 2004; 40(1): 57-63[PubMed]
  • 36. Kolbekova P, Kourbatova E, Novotna M, Kodym P, Flegr J. New and old risk-factors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech Republic. Clin Microbiol Infect. 2007; 13(10): 1012-7[DOI][PubMed]
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