Jundishapur Journal of Microbiology

Published by: Kowsar

Interferon-Gamma and Interlukin-4 Patterns in BALB/c Mice Suffering From Cutaneous Leishmaniasis Treated With Cantharidin

Yahya Maroufi 1 , Fatemeh Ghaffarifar 2 , * , Abdolhosein Dalimi 2 and Zohreh Sharifi 3
Authors Information
1 Department of Parasitology, Faculty of Medical Sciences, Zabol University of Medical Sciences, Zabol, IR Iran
2 Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
3 Department of Virology, Iranian Blood Transfusion Organization, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: June 01, 2014, 7 (6); e10907
  • Published Online: June 1, 2014
  • Article Type: Research Article
  • Received: March 4, 2013
  • Revised: June 1, 2013
  • Accepted: June 16, 2013
  • DOI: 10.5812/jjm.10907

To Cite: Maroufi Y, Ghaffarifar F, Dalimi A, Sharifi Z. Interferon-Gamma and Interlukin-4 Patterns in BALB/c Mice Suffering From Cutaneous Leishmaniasis Treated With Cantharidin, Jundishapur J Microbiol. 2014 ; 7(6):e10907. doi: 10.5812/jjm.10907.

Abstract
Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Hepburn NC. Cutaneous leishmaniasis. Clin Exp Dermatol. 2000; 25(5): 363-70[PubMed]
  • 2. Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S. Cutaneous leishmaniasis. Lancet Infect Dis. 2007; 7(9): 581-96[DOI][PubMed]
  • 3. Bonness K, Aragon IV, Rutland B, Ofori-Acquah S, Dean NM, Honkanen RE. Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha. Mol Cancer Ther. 2006; 5(11): 2727-36[DOI][PubMed]
  • 4. Moed L, Shwayder TA, Chang MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001; 137(10): 1357-60[PubMed]
  • 5. Deponte M. Programmed cell death in protists. Biochim Biophys Acta. 2008; 1783(7): 1396-405[DOI][PubMed]
  • 6. Yousefi M. From blisters beetle untile cantharidin. Darmangar. 2004; 3: 36-9
  • 7. Li YM, Casida JE. Cantharidin-binding protein: identification as protein phosphatase 2A. Proc Natl Acad Sci U S A. 1992; 89(24): 11867-70[PubMed]
  • 8. Eldridge GD, St Lawrence JS, Little CE, Shelby MC, Brasfield TL. Barriers to condom use and barrier method preferences among low-income African-American women. Women Health. 1995; 23(1): 73-89[DOI][PubMed]
  • 9. Wang XH, Yin YQ, Sui CG, Meng FD, Ma P, Jiang YH. Inhibitory effect of Cantharidin on proliferation of A549 cells. Chin J Cancer Res. 2007; 19(4): 283-6[DOI]
  • 10. Sagawa M, Nakazato T, Uchida H, Ikeda Y, Kizaki M. Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci. 2008; 99(9): 1820-6[DOI][PubMed]
  • 11. Fan YZ, Fu JY, Zhao ZM, Chen CQ. Influence of norcantharidin on proliferation, proliferation-related gene proteins proliferating cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-SD cells. Hepatobiliary Pancreat Dis Int. 2004; 3(4): 603-7[PubMed]
  • 12. Rauh R, Kahl S, Boechzelt H, Bauer R, Kaina B, Efferth T. Molecular biology of cantharidin in cancer cells. Chin Med. 2007; 2: 8[DOI][PubMed]
  • 13. Marufi Y, Ghaffarifar F, Dalimi A, Sharifi Z, Hassan ZM. Cantharidin-induced apoptosis in Leishmania major promastigotes and macrophages infected by Leishmania major amastigotes in-vitro. J Mazandaran Univ Med Sci. 2012; 22(87): 33-40
  • 14. Maroufi Y, Ghaffarifar F, Dalimi A, Sharifi Z, Hasan Z. A study on the cytotoxic effect of cantharidin on Leishmania major promastigote and amastigote survival in vitro. Feyz J Kashan Univ Med Sci. 2012; 16(5): 406-13
  • 15. Maroufi Y, Ghaffarifar F, Dalimi A, Sharifi Z, Hasan Z. Effect of Cantharidin on Apoptosis of the Leishmania major and on Parasite Load in BALB/c Mice. Res J Parasitol. 2013; 8(1)
  • 16. Sharma U, Singh S. Immunobiology of leishmaniasis. Indian J Exp Biol. 2009; 47(6): 412-23[PubMed]
  • 17. Rosas LE, Keiser T, Pyles R, Durbin J, Satoskar AR. Development of protective immunity against cutaneous leishmaniasis is dependent on STAT1-mediated IFN signaling pathway. Eur J Immunol. 2003; 33(7): 1799-805[DOI][PubMed]
  • 18. Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med. 1994; 179(4): 1367-71[PubMed]
  • 19. Dinh PH, Corraza F, Mestdagh K, Kassengera Z, Doyen V, Michel O. Validation of the cantharidin-induced skin blister as an in vivo model of inflammation. Br J Clin Pharmacol. 2011; 72(6): 912-20[DOI][PubMed]
  • 20. Nylen S, Gautam S. Immunological perspectives of leishmaniasis. J Glob Infect Dis. 2010; 2(2): 135-46[DOI][PubMed]
  • 21. Zou XJ, Liu HP, Cheng T, Shi L, Zu P, Zhang YJ. [A technique for investigating the component of cantharidin blisters by flow cytometry]. Zhong Yao Cai. 2007; 30(7): 823-5[PubMed]
  • 22. Hsieh CH, Huang YC, Tsai TH, Chen YJ. Cantharidin modulates development of human monocyte-derived dendritic cells. Toxicol In Vitro. 2011; 25(8): 1740-7[DOI][PubMed]
  • 23. Chen YC, Chang SC, Wu MH, Chuang KA, Wu JY, Tsai WJ, et al. Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells. Life Sci. 2009; 84(7-8): 218-26[DOI][PubMed]
  • 24. Liao HF, Chen YJ, Chou CH, Wang FW, Kuo CD. Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production. Toxicol In Vitro. 2011; 25(1): 206-12[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments