Jundishapur Journal of Microbiology

Published by: Kowsar

Hepatitis B Virus Genotyping Among Chronic Hepatitis B Individuals With Resistance to Lamivudine in Shahrekord, Iran

Ali Karimi 1 , Loghman Salimzadeh 1 , * and Nader Bagheri 2
Authors Information
1 Medicinal Plant Research Center, Shahrekord University of Medical Sciences, Shahrekord, IR Iran
2 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: April 01, 2014, 7 (4); e10196
  • Published Online: April 1, 2014
  • Article Type: Research Article
  • Received: February 4, 2013
  • Revised: May 5, 2013
  • Accepted: May 11, 2013
  • DOI: 10.5812/jjm.10196

To Cite: Karimi A, Salimzadeh L, Bagheri N. Hepatitis B Virus Genotyping Among Chronic Hepatitis B Individuals With Resistance to Lamivudine in Shahrekord, Iran, Jundishapur J Microbiol. 2014 ; 7(4):e10196. doi: 10.5812/jjm.10196.

Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Alter MJ. Epidemiology and prevention of hepatitis B. Semin Liver Dis. 2003; 23(1): 39-46[DOI][PubMed]
  • 2. Maddrey WC. Hepatitis B--an important public health issue. Clin Lab. 2001; 47(1-2): 51-5[PubMed]
  • 3. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol. 2004; 72(3): 363-9[DOI][PubMed]
  • 4. Mahoney FJ. Update on diagnosis, management, and prevention of hepatitis B virus infection. Clin Microbiol Rev. 1999; 12(2): 351-66[PubMed]
  • 5. Hannoun C, Horal P, Lindh M. Long-term mutation rates in the hepatitis B virus genome. J Gen Virol. 2000; 81: 75-83[PubMed]
  • 6. Kidd-Ljunggren K, Miyakawa Y, Kidd AH. Genetic variability in hepatitis B viruses. J Gen Virol. 2002; 83: 1267-80[PubMed]
  • 7. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988; 69 ( Pt 10): 2575-83[PubMed]
  • 8. Liu WC, Phiet PH, Chiang TY, Sun KT, Hung KH, Young KC, et al. Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics. Virus Res. 2007; 129(2): 212-23[DOI][PubMed]
  • 9. Datta S. An overview of molecular epidemiology of hepatitis B virus (HBV) in India. Virol J. 2008; 5: 156[DOI][PubMed]
  • 10. Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, et al. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 2001; 34(3): 590-4[DOI][PubMed]
  • 11. Chin R, Locarnini S. Treatment of chronic hepatitis B: current challenges and future directions. Rev Med Virol. 2003; 13(4): 255-72[DOI][PubMed]
  • 12. Lai CL, Ratziu V, Yuen MF, Poynard T. Viral hepatitis B. Lancet. 2003; 362(9401): 2089-94[DOI][PubMed]
  • 13. Patel PC, Cockcroft DW. Occupational asthma caused by exposure to cooking lobster in the work environment: a case report. Ann Allergy. 1992; 68(4): 360-1[PubMed]
  • 14. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus--large-scale analysis using a new genotyping method. J Infect Dis. 1997; 175(6): 1285-93[PubMed]
  • 15. Amini-Bavil-Olyaee S, Sarrami-Forooshani R, Adeli A, Sabahi F, Abachi M, Azizi M, et al. Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates from Iran. J Med Virol. 2005; 76(3): 318-26[DOI][PubMed]
  • 16. Mojiri A, Behzad-Behbahani A, Saberifirozi M, Ardabili M, Beheshti M, Rahsaz M, et al. Hepatitis B virus genotypes in southwest Iran: molecular, serological and clinical outcomes. World J Gastroenterol. 2008; 14(10): 1510-3[PubMed]
  • 17. Bahramali G, Sadeghizadeh M, Amini-Bavil-Olyaee S, Alavian SM, Behzad-Behbahani A, Adeli A, et al. Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients. World J Gastroenterol. 2008; 14(35): 5448-53[PubMed]
  • 18. Merat S, Rezvan H, Nouraie M, Jamali A, Assari S, Abolghasemi H, et al. The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study. Arch Iran Med. 2009; 12(3): 225-31[PubMed]
  • 19. Severini A, Liu XY, Wilson JS, Tyrrell DL. Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine. Antimicrob Agents Chemother. 1995; 39(7): 1430-5[PubMed]
  • 20. Dienstag JL, Schiff ER, Wright TL, Perrillo RP, Hann HW, Goodman Z, et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med. 1999; 341(17): 1256-63[DOI][PubMed]
  • 21. Lai CL, Chien RN, Leung NW, Chang TT, Guan R, Tai DI, et al. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. N Engl J Med. 1998; 339(2): 61-8[DOI][PubMed]
  • 22. Wang JH, Lu SN, Lee CM, Lee JF, Chou YP. Fatal hepatic failure after emergence of the hepatitis B virus mutant during lamivudine therapy in a patient with liver cirrhosis. Scand J Gastroenterol. 2002; 37(3): 366-9[PubMed]
  • 23. Kao JH, Liu CJ, Chen DS. Hepatitis B viral genotypes and lamivudine resistance. J Hepatol. 2002; 36(2): 303-4[PubMed]
  • 24. Papatheodoridis GV, Dimou E, Papadimitropoulos V. Nucleoside analogues for chronic hepatitis B: antiviral efficacy and viral resistance. Am J Gastroenterol. 2002; 97(7): 1618-28[DOI][PubMed]
  • 25. Bottecchia M, Souto FJ, O KM, Amendola M, Brandao CE, Niel C, et al. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiol. 2008; 8: 11[DOI][PubMed]
  • 26. Zollner B, Petersen J, Puchhammer-Stockl E, Kletzmayr J, Sterneck M, Fischer L, et al. Viral features of lamivudine resistant hepatitis B genotypes A and D. Hepatology. 2004; 39(1): 42-50[DOI][PubMed]
  • 27. Allen MI, Deslauriers M, Andrews CW, Tipples GA, Walters KA, Tyrrell DL, et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. Hepatology. 1998; 27(6): 1670-7[DOI][PubMed]
  • 28. Palumbo E. Hepatitis B genotypes and response to antiviral therapy: a review. Am J Ther. 2007; 14(3): 306-9[DOI][PubMed]
  • 29. Karimi A, Hoseini SM. Seroprevalence of hepatitis B and C virus and HIV markers among blood donors from Shahre-Kord, Iran (2004-2006). Kuwait Med J. 2008; 40(4): 279-81
  • 30. Mokhtarian K, Karimi A. Evaluation of Vaccine Induced Immunity to Hepatitis B Virus among Health Care Workers in a University Hospital in Iran. Kuwait Med J. 2010; 42: 202-4
  • 31. Karimi A, Imani R. [Prevalence of Hbsag, Hcv And Hiv Antibodies Among Intravenous Drug Users In Shahre-Kord, Iran]. J Isfahan Med School. 2007; 8: 10-4
  • 32. Zhang XH, Zhang YX, Sun LR, Wen Q, Zhou LQ, Fan GX, et al. [Study of gene chips in the detection of YMDD mutations in the region of HBV polymeras]. Zhonghua Yi Xue Za Zhi. 2003; 83(6): 459-62[PubMed]
  • 33. Akarsu M, Sengonul A, Tankurt E, Sayiner AA, Topalak O, Akpinar H, et al. YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa HBV DR assay. J Gastroenterol Hepatol. 2006; 21(12): 1783-8[DOI][PubMed]
  • 34. Yan MH, Zhang C, Ling Q, Zhou RF. [Detection of YMDD motif mutations in lamivudine-untreated patients with chronic hepatitis B]. Zhonghua Gan Zang Bing Za Zhi. 2003; 11(7): 430-1[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments