Jundishapur Journal of Microbiology

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Detection of GES-2, a Class A β-Lactamase Produced by Pseudomonas aeruginosa in a Teaching Hospital in Iran

Zahra Tavajjohi 1 , Rezvan Moniri 2 , 3 , * and Mahbube Zarrabi 4
Authors Information
1 Department of Biology, Faculty of Science, Alzahra University, Tehran, IR Iran
2 Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran
3 Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
4 Department of Biology, Faculty of Science, Alzahra University, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: December 01, 2013, 6 (10); e8166
  • Published Online: December 1, 2013
  • Article Type: Brief Report
  • Received: September 13, 2012
  • Revised: February 23, 2013
  • Accepted: June 30, 2013
  • DOI: 10.5812/jjm.8166

To Cite: Tavajjohi Z, Moniri R, Zarrabi M. Detection of GES-2, a Class A β-Lactamase Produced by Pseudomonas aeruginosa in a Teaching Hospital in Iran, Jundishapur J Microbiol. 2013 ; 6(10):e8166. doi: 10.5812/jjm.8166.

Abstract
Copyright © 2013, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Canton R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect. 2008; 14 Suppl 1: 144-53[DOI][PubMed]
  • 2. Poirel L, Le Thomas I, Naas T, Karim A, Nordmann P. Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Antimicrob Agents Chemother. 2000; 44(3): 622-32[PubMed]
  • 3. Weldhagen GF, Poirel L, Nordmann P. Ambler class A extended-spectrum beta-lactamases in Pseudomonas aeruginosa: novel developments and clinical impact. Antimicrob Agents Chemother. 2003; 47(8): 2385-92[PubMed]
  • 4. Frase H, Smith CA, Toth M, Champion MM, Mobashery S, Vakulenko SB. Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. J Biol Chem. 2011; 286(16): 14396-409[DOI][PubMed]
  • 5. Weldhagen GF. Rapid detection and sequence-specific differentiation of extended-spectrum beta-lactamase GES-2 from Pseudomonas aeruginosa by use of a real-time PCR assay. Antimicrob Agents Chemother. 2004; 48(10): 4059-62[DOI][PubMed]
  • 6. Poirel L, Weldhagen GF, Naas T, De Champs C, Dove MG, Nordmann P. GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem. Antimicrob Agents Chemother. 2001; 45(9): 2598-603[PubMed]
  • 7. Poirel L, Weldhagen GF, De Champs C, Nordmann P. A nosocomial outbreak of Pseudomonas aeruginosa isolates expressing the extended-spectrum beta-lactamase GES-2 in South Africa. J Antimicrob Chemother. 2002; 49(3): 561-5[PubMed]
  • 8. Performance standards for antimicrobial disk susceptibility tests. 2000;
  • 9. Castanheira M, Mendes RE, Walsh TR, Gales AC, Jones RN. Emergence of the extended-spectrum beta-lactamase GES-1 in a Pseudomonas aeruginosa strain from Brazil: report from the SENTRY antimicrobial surveillance program. Antimicrob Agents Chemother. 2004; 48(6): 2344-5[DOI][PubMed]
  • 10. Weldhagen GF. GES: an emerging family of extended spectrum beta-lactamases. Clin Microbiol News. 2006; 28(19): 145-149[DOI]
  • 11. Weldhagen GF, Prinsloo A. Molecular detection of GES-2 extended spectrum Beta-lactamase producing Pseudomonas aeruginosa in Pretoria, South Africa. Int J Antimicrob Agents. 2004; 24(1): 35-8[DOI][PubMed]
  • 12. Hirakawa Y, Sasaki H, Kawamoto E, Ishikawa H, Matsumoto T, Aoyama N, et al. Prevalence and analysis of Pseudomonas aeruginosa in chinchillas. BMC Vet Res. 2010; 6: 52[DOI][PubMed]
  • 13. Tam VH, Chang KT, Abdelraouf K, Brioso CG, Ameka M, McCaskey LA, et al. Prevalence, resistance mechanisms, and susceptibility of multidrug-resistant bloodstream isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010; 54(3): 1160-4[DOI][PubMed]
  • 14. Bonomo RA, Szabo D. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin Infect Dis. 2006; 43 Suppl 2-56[DOI][PubMed]
  • 15. Webber MA, Piddock LJ. The importance of efflux pumps in bacterial antibiotic resistance. J Antimicrob Chemother. 2003; 51(1): 9-11[PubMed]
  • 16. Aggarwal R, Chaudhary U, Bala K. Detection of extended-spectrum beta-lactamase in Pseudomonas aeruginosa. Indian J Pathol Microbiol. 2008; 51(2): 222-4[PubMed]
  • 17. Chayakulkeeree M, Junsriwong P, Keerasuntonpong A, Tribuddharat C, Thamlikitkul V. Epidemiology of extended-spectrum beta-lactamase producing gram-negative bacilli at Siriraj Hospital, Thailand, 2003. Southeast Asian J Trop Med Public Health. 2005; 36(6): 1503-9[PubMed]
  • 18. Celenza G, Pellegrini C, Caccamo M, Segatore B, Amicosante G, Perilli M. Spread of bla(CTX-M-type) and bla(PER-2) beta-lactamase genes in clinical isolates from Bolivian hospitals. J Antimicrob Chemother. 2006; 57(5): 975-8[DOI][PubMed]
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