Jundishapur Journal of Microbiology

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The incidence of Drug- Resistant Mutants in Patients With Chronic HBV Infection After Lamivudine Treatment

Sepide Ezzatpanah Fard 1 , 2 , Zohreh Sharifi 1 , * , Seyed Masoud Hosseini 2 and Mahmood Mahmoodian Shooshtari 1
Authors Information
1 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran
2 Department of Microbiology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Jundishapur Journal of Microbiology: October 01, 2013, 6 (8); e7366
  • Published Online: October 1, 2013
  • Article Type: Research Article
  • Received: July 22, 2012
  • Revised: October 29, 2012
  • Accepted: December 8, 2012
  • DOI: 10.5812/jjm.7366

To Cite: Ezzatpanah Fard S, Sharifi Z, Hosseini S M, Mahmoodian Shooshtari M. The incidence of Drug- Resistant Mutants in Patients With Chronic HBV Infection After Lamivudine Treatment, Jundishapur J Microbiol. 2013 ; 6(8):e7366. doi: 10.5812/jjm.7366.

Copyright © 2013, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Chan K, Yam I, Yuen J, Yuen MF, Lai CL, Alexander GJ, et al. A comprehensive HBV array for the detection of HBV mutants and genotype. Clin Biochem. 2011; 44(14-15): 1253-60[DOI][PubMed]
  • 2. Ma Y, Ding Y, Juan F, Dou XG. Genotyping the hepatitis B virus with a fragment of the HBV DNA polymerase gene in Shenyang, China. Virol J. 2011; 8: 315[DOI][PubMed]
  • 3. Levinson Warren, Jawetz Ernest. Medical microbiology and immunology. 2001; : 403-41
  • 4. Blitz L, Pujol FH, Swenson PD, Porto L, Atencio R, Araujo M, et al. Antigenic diversity of hepatitis B virus strains of genotype F in Amerindians and other population groups from Venezuela. J Clin Microbiol. 1998; 36(3): 648-51[PubMed]
  • 5. Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, et al. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 2001; 34(3): 590-4[DOI][PubMed]
  • 6. Zhu R, Zhang HP, Yu H, Li H, Ling YQ, Hu XQ, et al. Hepatitis B virus mutations associated with in situ expression of hepatitis B core antigen, viral load and prognosis in chronic hepatitis B patients. Pathol Res Pract. 2008; 204(10): 731-42[DOI][PubMed]
  • 7. Furusyo N, Nakashima H, Kashiwagi K, Kubo N, Hayashida K, Usuda S, et al. Clinical outcomes of hepatitis B virus (HBV) genotypes B and C in Japanese patients with chronic HBV infection. Am J Trop Med Hyg. 2002; 67(2): 151-7[PubMed]
  • 8. Sallam TA, William Tong CY. African links and hepatitis B virus genotypes in the Republic of Yemen. J Med Virol. 2004; 73(1): 23-8[DOI][PubMed]
  • 9. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988; 69 ( Pt 10): 2575-83[PubMed]
  • 10. Sharifi Z, Yari F, Gharebaghiyan A. Sequence analysis of the polymerase gene in hepatitis B virus infected blood donors in Iran. Arch Iran Med. 2012; 15(2): 88-90[PubMed]
  • 11. Zali Mohammad Reza. Hepatitis B resistance in Iran. Gastroenterol Hepatol Bed Bench. 2010; 3(2)
  • 12. Locarnini S, Zoulim F. Molecular genetics of HBV infection. Antivir Ther. 2010; 15 Suppl 3: 3-14[DOI][PubMed]
  • 13. Robinson SW. Hepatitis B Virus. 1990;
  • 14. Keeffe EB, Dieterich DT, Pawlotsky JM, Benhamou Y. Chronic hepatitis B: preventing, detecting, and managing viral resistance. Clin Gastroenterol Hepatol. 2008; 6(3): 268-74[DOI][PubMed]
  • 15. Chen CH, Lee CM, Tung WC, Wang JH, Hung CH, Hu TH, et al. Evolution of full-length HBV sequences in chronic hepatitis B patients with sequential lamivudine and adefovir dipivoxil resistance. J Hepatol. 2010; 52(4): 478-85[DOI][PubMed]
  • 16. Vincenti D, Solmone M, Garbuglia AR, Iacomi F, Capobianchi MR. A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations. J Virol Methods. 2009; 159(1): 53-7[DOI][PubMed]
  • 17. Ghany MG, Doo EC. Antiviral resistance and hepatitis B therapy. Hepatology. 2009; 49(5 Suppl)-84[DOI][PubMed]
  • 18. Liaw YF, Chien RN, Yeh CT, Tsai SL, Chu CM. Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. Hepatology. 1999; 30(2): 567-72[DOI][PubMed]
  • 19. Tipples GA, Ma MM, Fischer KP, Bain VG, Kneteman NM, Tyrrell DL. Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology. 1996; 24(3): 714-7[DOI][PubMed]
  • 20. Leung NW, Lai CL, Chang TT, Guan R, Lee CM, Ng KY, et al. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology. 2001; 33(6): 1527-32[DOI][PubMed]
  • 21. Liaw YF, Sung JJ, Chow WC, Farrell G, Lee CZ, Yuen H, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004; 351(15): 1521-31[DOI][PubMed]
  • 22. Ghandehari F, Pourazar A, Zadeh MS, Tajedin N. Probing rate of YMDD motif mutant in lamivudine treatment of Iranian patients with chronic hepatitis B virus infection. Asian J Transfus Sci. 2011; 5(1): 32-4[DOI][PubMed]
  • 23. Li D, Gu HX, Zhang SY, Zhong ZH, Zhuang M, Hattori T. YMDD mutations and genotypes of hepatitis B virus in northern China. Jpn J Infect Dis. 2006; 59(1): 42-5[PubMed]
  • 24. Ramezani A, Velayati AA, Roshan MR, Gachkar L, Banifazl M, Keyvani H, et al. Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection. Int J Infect Dis. 2008; 12(3): 252-5[DOI][PubMed]
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