Jundishapur Journal of Microbiology

Published by: Kowsar

Prevalence of Resistance of Helicobacter pylori Strains to Selected Antibiotics in Isfahan, Iran

Nasrin Mirzaei 1 , Farkhondeh Poursina 2 , Jamshid Faghri 2 , Majid Talebi 3 , Mohammad Reza Khataminezhad 1 , Akbar Hasanzadeh 4 and Hajieh Ghasemian Safaei 2 , *
Authors Information
1 Department of Biology, Tonekabon branch, Islamic Azad University, Tonekabon, IR Iran
2 Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, IR Iran
3 Department of Gastroenterology, Isfahan University of Medical Sciences, Isfahan, IR Iran
4 Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Jundishapur Journal of Microbiology: July 01, 2013, 6 (5); e6342
  • Published Online: July 1, 2013
  • Article Type: Research Article
  • Received: May 14, 2012
  • Revised: July 31, 2012
  • Accepted: August 8, 2012
  • DOI: 10.5812/jjm.6342

To Cite: Mirzaei N, Poursina F, Faghri J, Talebi M, Khataminezhad M R, et al. Prevalence of Resistance of Helicobacter pylori Strains to Selected Antibiotics in Isfahan, Iran, Jundishapur J Microbiol. 2013 ; 6(5):e6342. doi: 10.5812/jjm.6342.

Copyright © 2013, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Jenks PJ, Edwards DI. Metronidazole resistance in Helicobacter pylori. Int J Antimicrob Ag. 2002; 19(1): 1-7
  • 2. Sirous M, Mehrabadi JF, Daryani NE, Eshraghi S, Hajikhani S, Shirazi MH. Prevalence of antimicrobial resistance in Helicobacter pylori isolates from Iran. Afr J Biotech. 2011; 9(36): 5962-5965
  • 3. Fallahi GH, Maleknejad S. Helicobacter pylori culture and antimicrobial resistance in Iran. Indian J Pediatrics. 2007; 74(2): 127-130
  • 4. Dzierzanowska-Fangrat K, Rozynek E, Celinska-Cedro D, Jarosz M, Pawlowska J, Szadkowski A, et al. Antimicrobial resistance of Helicobacter pylori in Poland: a multicentre study. Int J Antimicrob Agents. 2005; 26(3): 230-4[DOI][PubMed]
  • 5. Ghasemian Safaei H, Tavakkoli H, Mojtahedi A, Salehei R, Soleimani B, Pishva E. Correlation of cagA positive Helicobacter pylori Infection with clinical outcomes in Al-zahra hospital, Isfahan, Iran. J Res Med Sci. 2008; 13(4): 196-201
  • 6. Kumala W, Rani A. Patterns of Helicobacter pylori isolate resistance to fluoroquinolones, amoxicillin, clarithromycin and metronidazoles. Southeast Asian J Trop Med Public Health. 2006; 37(5): 970-4[PubMed]
  • 7. Bahrami AR, Aminipour Harandi MR, Kazemi Kheirabadi E, Sharifian B, hasemian Safaei HG, Rahimi E. Antimicrobial Resistance of Helicobacter pylori Isolates from Cow Feces, Raw Milk and Drinking Water in Iran. Middle East J Sci Res. 2011; 10(6): 698-701
  • 8. Hosseini E, Poursina F, Van de Wiele T, Ghasemian Safaei H, Adibi P. Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases. J Res Med Sci. 2012; 17(3): 280
  • 9. Ghasemian Safaei H, Havaei SA, Tavakkoli H, Eshaghei M, Navabakbar F, Salehei R. Relation of bab A2 genotype of Helicobacter pylori infection with chronic active gastritis, duodenal ulcer and non-cardia active gastritis in Al-zahra hospital Isfahan, Iran. Jundishapur J Microbiol.. 2010; 3(3): 93-98
  • 10. Hajiani E, Hashemi J, Vosoghi T. Comparision of a 10 day triple and two week quadruple therapy in eradicating Helicobacter pylori infection in patients referred to Imam Khomeini hospital clinics Ahwaz, Iran. Jundishapur J Nat Pharm Prod. 2007; 3(1): 45-52
  • 11. Marie MA. Patterns of Helicobacter pylori resistance to metronidazole, clarithormycin and amoxicillin in Saudi Arabia. J Bacteriol Virol. 2008; 38(4): 173-178
  • 12. Kim SY, Joo YM, Lee HS, Chung IS, Yoo YJ, Merrell DS, et al. Genetic analysis of Helicobacter pylori clinical isolates suggests resistance to metronidazole can occur without the loss of functional rdxA. J Antibiot (Tokyo). 2009; 62(1): 43-50[DOI][PubMed]
  • 13. Canton R, Martin de Argila C, De Rafael L, Baquero F. Antimicrobial resistance in Helicobacter pylori. Rev Med Microbiol. 2001; 12(1): 47
  • 14. Haghi Tomatari F, Mohabbati Mobarez A, Amini M, Hosseini D, Talebi Bezmin Abadi A. Helicobacter pylori Resistance to Metronidazole and Clarithromycin in Dyspeptic Patients in Iran. Iran Red Cres Med J. 2010; 12(4): 409-412
  • 15. Siavashi F, Heydarian E, Pourkhajeh AH, Merat sh, Asl soleymani H, Khatibian M, et al. Susceptibility of various strains of Helicobacter pylori to selected agents. Arch Iran Med. 2000; 3(2)
  • 16. Shimoyama T, Fukuda S, Mikami T, Fukushi M, Munakata A. Efficacy of metronidazole for the treatment of clarithromycin-resistant Helicobacter pylori infection in a Japanese population. J Gastroenterol. 2004; 39(10): 927-30[DOI][PubMed]
  • 17. Hu CT, Chiou PY, Wu CC, Tseng YH, Chang YJ, Lin NT. Analysis of Resistance to Clarithromycin and Virulence Markers in Helicobacter pylori Clinical Isolates from Eastern Taiwan. Tzu Chi Med J. 2009; 21(2): 123-128
  • 18. Susceptibility testing of Helicobacter pylori. 2000;
  • 19. Seck A, Mbengue M, Gassama-Sow A, Diouf L, Ka MM, Boye CS. Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal. J Infect Dev Ctries. 2009; 3(2): 137-40[PubMed]
  • 20. Best LM, Haldane DJ, Keelan M, Taylor DE, Thomson AB, Loo V, et al. Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods. Antimicrob Agents Chemother. 1977; 47(10): 3138-44
  • 21. British methods for antimicrobial susceptibility testing (BSAC). 2012;
  • 22. Farshad S, Alborzi A, Japoni A, Ranjbar R, Hosseini Asl K, Badiee P, et al. Antimicrobial susceptibility of Helicobacter pylori strains isolated from patients in Shiraz, Southern Iran. World J Gastroenterol. 2010; 16(45): 5746-51[PubMed]
  • 23. Khashei R, Shojaei H, Adibi P, Shavakhi A, Aslani MM, Daei N. Genetic diversity and drug resistance of Helicobacter pylori strains in Isfahan, Iran. Iran J Basic Med Sci. 2008; 11(3): 174-182
  • 24. Kulsuntiwong P, Chomvarin C, Chaicumpar K, Namwat W, Kaewkes W, Mairiang P, et al. Antimicrobial susceptibility of Helicobacter pylori isolated from gastric biopsies in dyspeptic patients. Southeast Asian J Trop Med Public Health. 2008; 39(6): 1102-9[PubMed]
  • 25. Destura RV, Labio ED, Barrett LJ, Alcantara CS, Gloria VI, Daez MLO, et al. Laboratory diagnosis and susceptibility profile of Helicobacter pylori infection in the Philippines. Ann Clin Microbiol Antimicrob. 2004; 3(1): 25
  • 26. Kohanteb J, Bazargani A, Saberi-Firoozi M, Mobasser A. Antimicrobial susceptibility testing of Helicobacter pylori to selected agents by agar dilution method in Shiraz-Iran. Indian J Med Microbiol. 2007; 25(4): 374-7[PubMed]
  • 27. Wollek K, Leodolter A, Malfertheiner P, Koenig W. Antibiotic susceptibility of Helicobacter pylori in Germany: stable primary resistance from 1995 to 2000. J Med Microbiol. 2002; 51(8): 705-709
  • 28. Falsafi T, Mobasheri F, Nariman F, Najafi M. Susceptibilities to different antibiotics of Helicobacter pylori strains isolated from patients at the pediatric medical center of Tehran, Iran. J Clin Microbiol. 2004; 42(1): 387-9[PubMed]
  • 29. Mohammadi M, Doroud D, Mohajerani N, Massarrat S. Helicobacter pylori antibiotic resistance in Iran. World J Gastroenterol. 2005; 11(38): 6009-13[PubMed]
  • 30. Siavoshi F, Safari F, Doratotaj D, Khatami GR, Fallahi GH, Mirnaseri MM. Antimicrobial resistance of Helicobacter pylori isolates from Iranian adults and children. Arch Iran Med. 2006; 9(4): 308-14[PubMed]
  • 31. Mansour B, Burucoa Ch, Zribi M, Masmoudi A, Karoui S, Kallel L, et al. Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study. Ann Clin Microbiol Antimicrob. 2010; 9: 22-22
  • 32. Lang L, Garcia F. Comparison of E-test and disk diffusion assay to evaluate resistance of Helicobacter pylori isolates to amoxicillin, clarithromycin, metronidazole and tetracycline in Costa Rica. Int J Antimicrob Agents. 2004; 24(6): 572-7[DOI][PubMed]
  • 33. Shokrzadeh L, Jafari F, Dabiri H, Baghaei K, Zojaji H, Alizadeh AH, et al. Antibiotic susceptibility profile of Helicobacter pylori isolated from the dyspepsia patients in Tehran, Iran. Saudi J Gastroenterol. 2011; 17(4): 261-4[DOI][PubMed]
  • 34. Kargar M, Baghernejad M, Doosti A, Ghorbani-Dalini S. Clarithromycin resistance and 23S rRNA mutations in Helicobacter pylori isolates in Iran. Afr J Microbiol Res. 2011; 5: 853-856
  • 35. Kim JJ, Reddy R, Lee M, Kim JG, El-Zaatari FA, Osato MS, et al. Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea. J Antimicrob Chemother. 2001; 47(4): 459-61[PubMed]
  • 36. Ling TK, Leung WK, Lee CC, Ng EK, Yung MY, Chung SS, et al. The antimicrobial susceptibility of Helicobacter pylori in Hong Kong (1997-2001). Helicobacter. 2002; 7(5): 327-8[PubMed]
  • 37. Elviss NC, Owen RJ, Breathnach A, Palmer C, Shetty N. Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000. J Med Microbiol. 2005; 54: 567-74[DOI][PubMed]
  • 38. Ahmad N, Zakaria WR, Abdullah SA, Mohamed R. Characterization of clarithromycin resistance in Malaysian isolates of Helicobacter pylori. World J Gastroenterol. 2009; 15(25): 3161-5
  • 39. Andrzejewska E, Szkaradkiewicz A, Karpinski T. Antimicrobial resistance of Helicobacter pylori clinical strains in the last 10 years. Pol J Microbiol. 2009; 58(4): 301-5[PubMed]
  • 40. Yamade M, Sugimoto M, Uotani T, Nishino M, Kodaira C, Furuta T. Resistance of Helicobacter pylori to quinolones and clarithromycin assessed by genetic testing in Japan. J Gastroenterol Hepatol. 2011; 26(9): 1457-61[DOI][PubMed]
  • 41. Vale FF, Rosa MR, Oleastro M. Helicobacter pylori resistance to antibiotics. Science against microbial pathogens: communicating current research and technological advances. 2011; : 745-756
  • 42. Eisig JN, Silva FM, Barbuti RC, Navarro-Rodriguez T, Moraes-Filho JP, Pedrazzoli Jr J. Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option. Arq Gastroenterol. 2011; 48(4): 261-4[PubMed]
  • 43. Lofmark S, Edlund C, Nord CE. Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis. 2010; 50 Suppl 1-23[DOI][PubMed]
  • 44. Gisbert JP. Rescue Therapy for Helicobacter pylori infection 2012. Gastroenterology res Pract. 2012; 2012
  • 45. Siavoshi F, Saniee P, Latifi-Navid S, Massarrat S, Sheykholeslami A. Increase in resistance rates of H. pylori isolates to metronidazole and tetracycline--comparison of three 3-year studies. Arch Iran Med. 2010; 13(3): 177-87[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments