Jundishapur Journal of Microbiology

Published by: Kowsar

Effect of Leptin on Neutrophils Phagocytosis and Lymphocytes Apoptosis Challenge by Listeria monocytogenes and Escherichia coli

Amir Morshedi 1 , Sayyed Hamid Zarkesh-Esfahani 1 , * and Mohaddeseh Behjati 2
Authors Information
1 Department of Biology, Faculty of Science, University of Isfahan, Isfahan, IR Iran
2 Isfahan Cardiovascular Research Institute, Isfahan Universityof Medical Sciences, Isfahan, IR Iran
Article information
  • Jundishapur Journal of Microbiology: September 01, 2013, 6 (7); e6389
  • Published Online: September 1, 2013
  • Article Type: Research Article
  • Received: May 17, 2012
  • Revised: October 17, 2012
  • Accepted: October 24, 2012
  • DOI: 10.5812/jjm.6389

To Cite: Morshedi A, Zarkesh-Esfahani S H, Behjati M. Effect of Leptin on Neutrophils Phagocytosis and Lymphocytes Apoptosis Challenge by Listeria monocytogenes and Escherichia coli, Jundishapur J Microbiol. 2013 ; 6(7):e6389. doi: 10.5812/jjm.6389.

Abstract
Copyright © 2013, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004; 4(5): 371-9[DOI][PubMed]
  • 2. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, et al. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005; 90(3): 1625-31[DOI][PubMed]
  • 3. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002; 110(8): 1093-103[DOI][PubMed]
  • 4. Moore SI, Huffnagle GB, Chen GH, White ES, Mancuso P. Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun. 2003; 71(7): 4182-5[PubMed]
  • 5. Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, et al. Role of leptin in the activation of immune cells. Mediators Inflamm. 2010; 2010: 568343[DOI][PubMed]
  • 6. Tian Z, Sun R, Wei H, Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002; 298(3): 297-302[PubMed]
  • 7. Economou M, Karyda S, Kansouzidou A, Kavaliotis J. Listeria meningitis in children: report of two cases. Infection. 2000; 28(2): 121-3[PubMed]
  • 8. Portnoy DA, Auerbuch V, Glomski IJ. The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol. 2002; 158(3): 409-14[DOI][PubMed]
  • 9. Birmingham CL, Canadien V, Kaniuk NA, Steinberg BE, Higgins DE, Brumell JH. Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature. 2008; 451(7176): 350-4[DOI][PubMed]
  • 10. Carrero JA, Calderon B, Unanue ER. Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule. J Immunol. 2004; 172(8): 4866-74[PubMed]
  • 11. Zychlinsky A, Sansonetti P. Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis. J Clin Invest. 1997; 100(3): 493-5[DOI][PubMed]
  • 12. Leib SL, Kim YS, Chow LL, Sheldon RA, Tauber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest. 1996; 98(11): 2632-9[DOI][PubMed]
  • 13. Savill J. Phagocyte recognition of apoptotic cells. Biochem Soc Trans. 1996; 24(4): 1065-9[PubMed]
  • 14. Carrero JA, Unanue ER. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends Immunol. 2006; 27(11): 497-503[DOI][PubMed]
  • 15. Gordon DL, Rice JL, McDonald PJ. Regulation of human neutrophil type 3 complement receptor (iC3b receptor) expression during phagocytosis of Staphylococcus aureus and Escherichia coli. Immunology. 1989; 67(4): 460-5[PubMed]
  • 16. Abbas KA, Lichtman AH, Pober JS. Cellular and Molecular Immunology. 1997;
  • 17. Caldefie-Chezet F, Poulin A, Tridon A, Sion B, Vasson MP. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J Leukoc Biol. 2001; 69(3): 414-8[PubMed]
  • 18. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol. 2002; 168(8): 4018-24[PubMed]
  • 19. Shirshev SV, Orlova EG. Molecular mechanisms of regulation of functional activity of mononuclear phagocytes by leptin. Biochemistry (Mosc). 2005; 70(8): 841-7[PubMed]
  • 20. Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M, et al. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J. 2000; 14(14): 2329-38[DOI][PubMed]
  • 21. Zarkesh-Esfahani H, Pockley AG, Wu Z, Hellewell PG, Weetman AP, Ross RJ. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol. 2004; 172(3): 1809-14[PubMed]
  • 22. Tian Z, Sun R, Wei H, Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002; 298(3): 297-302[PubMed]
  • 23. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998; 394(6696): 897-901[DOI][PubMed]
  • 24. Merrick JC, Edelson BT, Bhardwaj V, Swanson PE, Unanue ER. Lymphocyte apoptosis during early phase of Listeria infection in mice. Am J Pathol. 1997; 151(3): 785-92[PubMed]
  • 25. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006; 176(12): 7745-52[PubMed]
  • 26. Fujita Y, Murakami M, Ogawa Y, Masuzaki H, Tanaka M, Ozaki S, et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol. 2002; 128(1): 21-6[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments